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Cited by 320

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size

Open access
Jain, Vivek, Hartogensis, Wendy, Bacchetti, Peter, Hunt, Peter W., Hatano, Hiroyu, Sinclair, Elizabeth, Epling, Lorrie, Lee, Tzong-Hae, Busch, Michael P., McCune, Joseph M., Pilcher, Christopher D., Hecht, Frederick M., Deeks, Steven G.·2013·The Journal of Infectious Diseases
DOI 10.1093/infdis/jit311
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Abstract

Background. CD4(+)/CD8(+) T-cell activation levels often remain elevated in chronic human immunodeficiency virus (HIV) infection despite initiation of antiretroviral therapy (ART). T-cell activation predicts early death and blunted CD4+ T-cell recovery during ART and may affect persistent HIV reservoir size. We investigated whether very early ART initiation is associated with lower on-therapy immune activation and HIV persistence. Methods. From a cohort of patients with early HIV infection (<6 months duration since infection) we identified persons who started ART early (<6 months after infection) or later (≥2 years after infection) and maintained ≥2 years of virologic suppression; at-risk HIV-negative persons were controls. We measured CD4(+)/CD8(+) T-cell activation (percent CD38(+)/HLA-DR(+)) and HIV reservoir size (based on HIV DNA and cell-associated RNA levels). Results. In unadjusted analyses, early ART predicted lower on-therapy CD8(+) T-cell activation (n = 34; mean, 22.1%) than achieved with later ART (n = 32; mean, 28.8%; P = .009), although levels in early ART remained elevated relative to HIV-negative controls (P = .02). Early ART also predicted lower CD4+ T-cell activation than with later ART (5.3% vs 7.5%; P = .06). Early ART predicted 4.8-fold lower DNA levels than achieved with later ART (P = .005), and lower cell-associated RNA levels (difference in signal-to-cutoff ratio (S/Co), 3.2; P = .035). Conclusions. ART initiation <6 months after infection is associated with lower levels of T-cell activation and smaller HIV DNA and RNA reservoir size during long-term therapy.

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Metadata

Authors
Jain, V., Hartogensis, W., Bacchetti, P., Hunt, P. W., Hatano, H., Sinclair, E., Epling, L., Lee, T.-H., Busch, M. P., McCune, J. M., Pilcher, C. D., Hecht, F. M., & Deeks, S. G.
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2013-07-12
Volume
208
Issue
8
Pages
1202-1211
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/jit311
OpenAlex
W2167069127
Cited by
320
References
39
FWCI
14.22
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size. https://app.cochat.ai/papers/10.1093/infdis/jit311
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Jain, V., Hartogensis, W., Bacchetti, P., Hunt, P. W., Hatano, H., Sinclair, E., Epling, L., Lee, T.-H., Busch, M. P., McCune, J. M., Pilcher, C. D., Hecht, F. M., & Deeks, S. G. (2013). Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jit311

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.