Cited by 448SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral Infections and Outbreaks Research

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Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

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Chu, Hin, Zhou, Jie, Wong, Bosco Ho-Yin, Li, Cun, Chan, Jasper Fuk-Woo, Cheng, Zhong-Shan, Yang, Dong, Wang, Dong, Lee, Andrew Chak-Yiu, Li, Chuangen, Yeung, Man-Lung, Cai, Jian-Piao, Chan, Ivy Hau-Yee, Ho, Wai-Kuen, To, Kelvin Kai-Wang, Zheng, Bo-Jian, Yao, Yanfeng, Qin, Chuan, Yuen, Kwok-Yung·2016·Journal of Infectious Diseases

DOI 10.1093/infdis/jiv380PMC PMC7107330

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Abstract

Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.

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Authors: Chu, H., Zhou, J., Wong, B. H.-Y., Li, C., Chan, J. F.-W., Cheng, Z.-S., Yang, D., Wang, D., Lee, A. C.-Y., Li, C., Yeung, M.-L., Cai, J.-P., Chan, I. H.-Y., Ho, W.-K., To, K. K.-W., Zheng, B.-J., Yao, Y., Qin, C., & Yuen, K.-Y.
Affiliations: University of Hong Kong (HK)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Zhejiang University (CN)
Corresponding author: Chu, Hin
ORCID: Chu, Hin
Zhou, Jie
Li, Cun
Chan, Jasper Fuk-Woo
Yang, Dong
Wang, Dong
Lee, Andrew Chak-Yiu
Li, Chuangen
Yeung, Man-Lung
Cai, Jian-Piao
Chan, Ivy Hau-Yee
Ho, Wai-Kuen
To, Kelvin Kai-Wang
Yao, Yanfeng
Qin, Chuan
Yuen, Kwok-Yung
Venue: Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2015-07-22
Volume: 213
Issue: 6
Pages: 904-914
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jiv380
PMC: PMC7107330
OpenAlex: W1947409115
Cited by: 448
References: 50
Citations by year: 2026: 4 · 2025: 16 · 2024: 19 · 2023: 22 · 2022: 50 · 2021: 117 · 2020: 149 · 2019: 14 · 2018: 15 · 2017: 12 · 2016: 14 · 2015: 4
FWCI: 11.68
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Infectious Diseases (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Research Grants Council of the Hong Kong Special Administrative Region (T11/707/15)
Providence Foundation Limited
University of Hong Kong Small Project Funding (201409176024)
Hong Kong Health and Medical Research Fund (14131392)
Hong Kong Research Grants Council (N_HKU728/14)
National Science and Technology Major Projects of Infectious Disease (2012ZX10004501-004)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords: MERS-CoV, T cells, T cell infection, apoptosis, extrinsic apoptotic pathway, mitochondrial apoptosis, spleen, tonsil, marmoset, viral pathogenicity, lymphoid organs
MeSH terms: Animals, Antibodies, Viral, Callithrix, Cells, Cultured, Gene Expression Regulation, Humans, Spleen, T-Lymphocytes, Palatine Tonsil, Apoptosis, Dipeptidyl Peptidase 4, Severe acute respiratory syndrome-related coronavirus, Middle East Respiratory Syndrome Coronavirus

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Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

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