A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.

Simons, Brenna C.; Spradling, Philip R.; Bruden, Dana J. T.; Zanis, Carolyn; Case, Samantha; Choromanski, Tammy L.; Apodaca, Minjun; Brogdon, Hazel D.; Dwyer, Gaelen; Snowball, Mary; Negus, Susan; Bruce, Michael G.; Morishima, Chihiro; Knall, Cindy; McMahon, Brian J.

doi:10.1093/infdis/jiw142

Cited by 101Hepatitis B Virus StudiesHepatitis C virus researchIntramuscular injections and effects

A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.

Open access

Simons, Brenna C., Spradling, Philip R., Bruden, Dana J. T., Zanis, Carolyn, Case, Samantha, Choromanski, Tammy L., Apodaca, Minjun, Brogdon, Hazel D. +7 more·2016·Journal of Infectious Diseases

DOI 10.1093/infdis/jiw142PMC PMC4918827

Open this paper in CoChat — free account

Abstract

BACKGROUND: Long-lasting protection resulting from hepatitis B vaccine, despite loss of antibody against hepatitis B virus (HBV) surface antigen (anti-HBs), is undetermined. METHODS: We recruited persons from a cohort vaccinated with plasma-derived hepatitis B vaccine in 1981 who have been followed periodically since. We performed serological testing for anti-HBs and microRNA-155 and assessed HBV-specific T-cell responses by enzyme-linked immunospot and cytometric bead array. Study subgroups were defined 32 years after vaccination as having an anti-HBs level of either ≥10 mIU/mL (group 1; n = 13) or <10 mIU/mL (group 2; n = 31). RESULTS: All 44 participants, regardless of anti-HBs level, tested positive for tumor necrosis factor α, interleukin 10, or interleukin 6 production by HBV surface antigen-specific T cells. The frequency of natural killer T cells correlated with the level of anti-HBs (P = .008). The proportion of participants who demonstrated T-cell responses to HBV core antigen varied among the cytokines measured, suggesting some natural exposure to HBV in the study group. No participant had evidence of breakthrough HBV infection. CONCLUSIONS: Evidence of long-lasting cellular immunity, regardless of anti-HBs level, suggests that protection afforded by primary immunization with plasma-derived hepatitis B vaccine during childhood and adulthood lasts at least 32 years.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/infdis/jiw142

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vaccine-induced immune memory has been demonstrated to persist for >30 years.
“Vaccine-induced immune memory has been demonstrated to persist for >30 years (1325–1327).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1327]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Biology of NKT Cells
Bendelac, A. S., Savage, P. B., & Teyton, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141711 · Cited by 2,169 · see citing works
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765 · see citing works
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547 · see citing works
Hepatitis B Vaccine
Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Oleszko, W. R., William, D. C., D, R. S. M., Morrison, J. M., & Kellner, A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198010093031501 · Cited by 1,117 · see citing works
PREVENTION OF PERINATALLY TRANSMITTED HEPATITIS B VIRUS INFECTIONS WITH HEPATITIS B IMMUNE GLOBULIN AND HEPATITIS B VACCINE
Beasley, R. P., LEE, G. C.-Y., Roan, C., Hwang, L., Lan, C., Huang, F.-Y., & Chen, C.-L. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90624-4 · Cited by 815 · see citing works
Long-Term Immunogenicity and Efficacy of Hepatitis B Vaccine in Homosexual Men
Hadler, S. C., Francis, D. P., Maynard, J. E., Thompson, S. E., Judson, F. N., Echenberg, D. F., Ostrow, D. G., OʼMalley, P. M., Penley, K. A., Altman, N. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150401 · Cited by 608 · see citing works
MATERNAL DEATHS
Newcombe, R. G. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90482-1 · Cited by 546 · see citing works
microRNAs and the immune response
Lindsay, M. A. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.04.004 · Cited by 532 · see citing works
Antibody levels and protection after hepatitis B vaccine: results of a 30-year follow-up study and response to a booster dose.
Bruce, M. G., Bruden, D., Hurlburt, D., Zanis, C., Thompson, G., Rea, L., Toomey, M., Townshend-Bulson, L., Rudolph, K., Bulkow, L., et al. (2016) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv748 · Cited by 322 · see citing works
Antibody Levels and Protection after Hepatitis B Vaccination: Results of a 15-Year Follow-up
McMahon, B. J., Bruden, D. L., Petersen, K. M., BULKOW, L. R., Parkinson, A. J., Nainan, O. V., Khristova, M. L., Zanis, C. L., Peters, H. V., & Margolis, H. S. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-5-200503010-00008 · Cited by 315 · see citing works
Antibody Levels and Protection after Hepatitis B Vaccine: Results of a 22‐Year Follow‐Up Study and Response to a Booster Dose
McMahon, B. J., Dentinger, C., Bruden, D. J. T., Zanis, C. L., Peters, H. V., Hurlburt, D., BULKOW, L. R., Fiore, A. E., Bell, B. P., & Hennessy, T. W. (2009) · The Journal of Infectious Diseases · doi:10.1086/606119 · Cited by 246 · see citing works
Hepatitis B Virus Genotypes in Alaska Native People with Hepatocellular Carcinoma: Preponderance of Genotype F
Livingston, S., Simonetti, J., McMahon, B. J., BULKOW, L. R., Hurlburt, K. J., Homan, C., Snowball, M. M., Cagle, H. H., Williams, J. L., & Chulanov, V. (2006) · The Journal of Infectious Diseases · doi:10.1086/509894 · Cited by 240 · see citing works
Hepatitis B surface antigen-specific T and B cell memory in individuals who had lost protective antibodies after hepatitis B vaccination
Bauer, T., & Jilg, W. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.058 · Cited by 215 · see citing works
Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch-up immunization program.
McMahon, B. J., Bulkow, L. R., Singleton, R. J., Williams, J., Snowball, M., Homan, C., & Parkinson, A. J. (2011) · Hepatology · doi:10.1002/hep.24442 · Cited by 201 · see citing works
Humoral and Cellular Immune Responses to a Hepatitis B Vaccine Booster 15–18 Years after Neonatal Immunization
Lu, C., Ni, Y., Chiang, B., Chen, P., Chang, M., Chang, L., Su, I., Kuo, H., Huang, L., Chen, D., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/587695 · Cited by 197 · see citing works
Protection Provided by Hepatitis B Vaccine in a Yupik Eskimo Population--Results of a 10-Year Study
Wainwright, R. B., BULKOW, L. R., Parkinson, A. J., Zanis, C. L., & McMahon, B. J. (1997) · The Journal of Infectious Diseases · doi:10.1093/infdis/175.3.674 · Cited by 182 · see citing works
Hepatitis B immunity in children vaccinated with recombinant hepatitis B vaccine beginning at birth: A follow-up study at 15 years☆
Hammitt, L. L., Hennessy, T., Fiore, A. E., Zanis, C. L., Hummel, K. B., Dunaway, E., BULKOW, L. R., & MCMAHON, B. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.06.059 · Cited by 167 · see citing works
Elimination of New Chronic Hepatitis B Virus Infections: Results of the Alaska Immunization Program
Harpaz, R., McMahon, B. J., Margolis, H. S., Shapiro, C. N., Havron, D., Carpenter, G., BULKOW, L. R., & Wainwright, R. B. (2000) · The Journal of Infectious Diseases · doi:10.1086/315259 · Cited by 156 · see citing works
Duration of Immunogenicity and Efficacy of Hepatitis B Vaccine in a Yupik Eskimo Population
Wainwright, R. B. (1989) · JAMA · doi:10.1001/jama.1989.03420160094029 · Cited by 147 · see citing works
Frequency of adverse reactions to hepatitis B vaccine in 43,618 persons
McMahon, B. J., Helminiak, C., Wainwright, R. B., BULKOW, L. R., Trimble, B. A., & Wainwright, K. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90073-k · Cited by 132 · see citing works
Duration of Hepatitis B Immunity in Low Risk Children Receiving Hepatitis B Vaccinations From Birth
Petersen, K. M., BULKOW, L. R., McMahon, B. J., Zanis, C. L., Getty, M., Peters, H. V., & Parkinson, A. J. (2004) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000130952.96259.fd · Cited by 129 · see citing works
Persistence of Antibody to Hepatitis B and Protection From Disease Among Alaska Natives Immunized at Birth
Dentinger, C., McMahon, B. J., Butler, J. C., Dunaway, C. E., Zanis, C. L., BULKOW, L. R., Bruden, D. L., Nainan, O. V., Khristova, M. L., Hennessy, T. W., et al. (2005) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000176617.63457.9f · Cited by 126 · see citing works
Hepatitis B surface antigen in saliva, impetiginous lesions, and the environment in two remote Alaskan villages
Petersen, N. J., Barrett, D. H., Bond, W. W., Berquist, K. R., Favero, M. S., Bender, T. R., & Maynard, J. E. (1976) · Applied and Environmental Microbiology · doi:10.1128/aem.32.4.572-574.1976 · Cited by 116 · see citing works
Differences in Response to a Hepatitis B Vaccine Booster Dose Among Alaskan Children and Adolescents Vaccinated During Infancy
Samandari, T., Fiore, A. E., Negus, S. E., Williams, J. L., Kuhnert, W. L., McMahon, B. J., & Bell, B. P. (2007) · PEDIATRICS · doi:10.1542/peds.2007-0131 · Cited by 109 · see citing works
Persistence of antibodies and immune memory to hepatitis B vaccine 20 years after infant vaccination in Thailand
Poovorawan, Y., Chongsrisawat, V., Theamboonlers, A., Bock, H. L., Leyssen, M., & Jacquet, J. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.10.074 · Cited by 104 · see citing works
Long–Term Response to Hepatitis B Vaccination and Response to Booster in Children Born to Mothers With Hepatitis B E Antigen
Huang, L., Chiang, B., Lee, C., Lee, P., Chi, W., & Chang, M. (1999) · Hepatology · doi:10.1002/hep.510290349 · Cited by 104 · see citing works
Twelve–Year Follow–Up of A Prospective Randomized Trial of Hepatitis B Recombinant Dna Yeast Vaccine Versus Plasma–Derived Vaccine Without Booster Doses in Children
Yuen, M., Lim, W.-L., Cheng, C.-C., Lam, S.-K., & Lai, C. (1999) · Hepatology · doi:10.1002/hep.510290327 · Cited by 75 · see citing works
Presence of immune memory and immunity to hepatitis B virus in adults after neonatal hepatitis B vaccination
Zhu, C., Liu, P., Chen, T., Ni, Z., Lu, L., Huang, F., Lu, J., Sun, Z., & Qu, C. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.07.098 · Cited by 69 · see citing works
Detection Methods for Study of the Stability of Hepatitis B Antigen on Surfaces
Favero, M. S., Bond, W. W., Petersen, N. J., Berquist, K. R., & Maynard, J. E. (1974) · The Journal of Infectious Diseases · doi:10.1093/infdis/129.2.210 · Cited by 63 · see citing works
Protection provided by hepatitis B vaccine in a Yupik Eskimo population. Seven-year results
Wainwright, R. B. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.8.1634 · Cited by 63 · see citing works
THE CONTROL OF HEPATITIS B VIRUS INFECTION WITH VACCINE IN YUPIK ESKIMOS
Heyward, W. L., Bender, T. R., McMahon, B. J., Hall, D. B., Francis, D. P., Lanier, A. P., Alward, W. L. M., AHTONE, J. L., Murphy, B. L., & Maynard, J. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114061 · Cited by 62 · see citing works
The Hepatitis B Vaccine Protects Re-Exposed Health Care Workers, But Does Not Provide Sterilizing Immunity
Werner, J. M., Abdalla, A., Gara, N., Ghany, M. G., & Rehermann, B. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.044 · Cited by 58 · see citing works
Evaluation of the response to a booster dose of hepatitis B vaccine in previously immunized healthcare workers
Williams, J. L., Christensen, C. J., McMahon, B. J., BULKOW, L. R., Cagle, H. H., Mayers, J. S., Zanis, C. L., Parkinson, A. J., & Margolis, H. S. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00112-8 · Cited by 50 · see citing works
Innate immune responses support adaptive immunity: NKT cells induce B cell activation
Galli, G., Nuti, S., Tavarini, S., Galli‐Stampino, L., de Lalla, C., Casorati, G., Dellabona, P., & Abrignani, S. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00200-7 · Cited by 49 · see citing works
Waning‐off effect of serum hepatitis B surface antibody amongst Taiwanese university students: 18 years post‐implementation of Taiwan’s national hepatitis B vaccination programme
Su, F., Chen, J. ‐., Cheng, S., Sung, K. ‐., Jeng, J. ‐., & Chu, F. (2007) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2007.00890.x · Cited by 43 · see citing works
Long-Term Humoral and Cellular Immune Response to Hepatitis B Vaccine in High-Risk Children 18–20 Years After Neonatal Immunization
Chinchai, T., Chirathaworn, C., Praianantathavorn, K., Theamboonlers, A., Hutagalung, Y., L., B. P. H., Thantiworasit, P., & Poovorawan, Y. (2009) · Viral Immunology · doi:10.1089/vim.2008.0087 · Cited by 39 · see citing works
Cytokine and Chemokine Responses in the Acute Phase of Hepatitis B Virus Replication in Naive and Previously Vaccinated Blood and Plasma Donors
Keating, S. M., Heitman, J. D., Wu, S., Deng, X., Stramer, S. L., Kuhns, M. C., Mullen, C., Norris, P. J., & Busch, M. P. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit563 · Cited by 38 · see citing works
Despite Biased TRBV Gene Usage against a Dominant HLA B57-Restricted Epitope, TCR Diversity Can Provide Recognition of Circulating Epitope Variants
Simons, B. C., VanCompernolle, S. E., Smith, R. M., Wei, J., Barnett, L. D., Lorey, S. L., Meyer‐Olson, D., & Kalams, S. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.5137 · Cited by 37 · see citing works
Assessing completeness of perinatal hepatitis B virus infection reporting through comparison of immunization program and surveillance data--United States.
(2011) · PubMed · Cited by 36 · see citing works
Increases in Levels of Antibody to Hepatitis B Surface Antigen in an Immunized Population
BULKOW, L. R., Wainwright, R. B., BULKOW, L. R., Wainwright, R. B., McMahon, B. J., & Parkinson, A. J. (1998) · Clinical Infectious Diseases · doi:10.1086/513939 · Cited by 33 · see citing works
Efficacy of hepatitis B vaccine boosters among neonatally vaccinated university freshmen in Taiwan
Su, F., Chu, F., Bai, C.-H., Lin, Y., Hsueh, Y., Sung, F.-C., & Yeh, C. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.036 · Cited by 31 · see citing works
Significance and anamnestic response in isolated hepatitis B core antibody-positive individuals 18 years after neonatal hepatitis B virus vaccination in Taiwan
Su, F., Bai, C., Chu, F., Lin, Y., Su, C., & Yeh, C. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.04.031 · Cited by 31 · see citing works
Choriodecidual Group B Streptococcal Infection Induces miR-155-5p in the Fetal Lung in Macaca nemestrina
McAdams, R. M., Bierle, C. J., Boldenow, E., Weed, S. E., Tsai, J. M., Beyer, R. P., MacDonald, J. W., Bammler, T. K., Liggitt, H. D., Farin, F. M., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00695-15 · Cited by 28 · see citing works
Long-term protection of neonatal hepatitis B vaccination in a 30-year cohort in Hong Kong
Lin, A. W.-C., & Wong, K.-H. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.021 · Cited by 28 · see citing works
Immunological Reactivity of Blood from Healthy Humans to the rAls3p‐N Vaccine Protein
Baquir, B., Lin, L., Ibrahim, A. S., Fu, Y., Avanesian, V., Tu, A. A., Edwards, J. E., & Spellberg, B. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/649901 · Cited by 23 · see citing works
Human Immune Responses to H. pylori HLA Class II Epitopes Identified by Immunoinformatic Methods
Zhang, S., Desrosiers, J., Aponte-Pieras, J. R., DaSilva, K., Fast, L. D., Terry, F. E., Martin, W. D., Groot, A. S. D., Moise, L., & Moss, S. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094974 · Cited by 20 · see citing works
An air sampling technique for hepatitis B surface antigen.
Petersen, N. J., Bond, W. W., Jh, M., Favero, M. S., & Raij, L. R. (1976) · PubMed · Cited by 19 · see citing works
Cellular immune responses in patients with hepatitis B surface antigen seroclearance induced by antiviral therapy
Liang, M.-F., Ma, S., Hu, X., Zhou, B., Zhang, J., Chen, J., Wang, Z., Sun, J., Zhu, X., Abbott, W. G. H., et al. (2011) · Virology Journal · doi:10.1186/1743-422x-8-69 · Cited by 18 · see citing works
Increased Serum MicroRNA-155 Level Associated with Nonresponsiveness to Hepatitis B Vaccine
Xiong, Y., Chen, S., Liu, L., Zhao, Y. D., Lin, W., & Ni, J. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00044-13 · Cited by 18 · see citing works
Vaccine induced protection against hepatitis B
Damme, P. V., & Banatvala, J. E. (2003) · BMJ · doi:10.1136/bmj.326.7380.105 · Cited by 6 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[32]Werner JM, Abdalla A, Gara N, Ghany MG, Rehermann B. Innate and adaptive immune responses correlate to antibody recall responses to hepatitis B booster vaccineation. Hepatology 2013; 58:612A–3. [Google Scholar]

Sorted by citations

Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
Prevention of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices.
Schillie, S., Vellozzi, C., Reingold, A., Harris, A., Haber, P., Ward, J. W., & Nelson, N. P. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6701a1 · Cited by 815 · see citing works
Hepatitis B Vaccines
Pattyn, J., Hendrickx, G., Vorsters, A., & Damme, P. V. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa668 · Cited by 285 · see citing works
Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention
Abara, W. E., Qaseem, A., Schillie, S. F., McMahon, B. J., & Harris, A. M. (2017) · Annals of Internal Medicine · doi:10.7326/m17-1106 · Cited by 150 · see citing works
Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?
Connell, A. R., Connell, J., Leahy, T. R., & Hassan, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02089 · Cited by 72 · see citing works
Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents
Duque, J. S. R., Wang, X., Leung, D., Cheng, S. M. S., Cohen, C. A., Mu, X., Hachim, A., Zhang, Y., Chan, S. M., Chaothai, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31485-z · Cited by 63 · see citing works
Protection and antibody levels 35 years after primary series with hepatitis B vaccine and response to a booster dose
Bruce, M. G., Bruden, D. J. T., Hurlburt, D. A., Morris, J. M., Bressler, S. S., Thompson, G. G., Lecy, D., Rudolph, K. M., BULKOW, L. R., Hennessy, T., et al. (2022) · Hepatology · doi:10.1002/hep.32474 · Cited by 59 · see citing works
Insights into induction of the immune response by the hepatitis B vaccine
Lello, F. A. D., Martínez, A. P., & Flichman, D. M. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i31.4249 · Cited by 50 · see citing works
Persistence of HB sAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults
Damme, P. V., Dionne, M., Leroux-Roels, G. G., Meeren, O. V. D., Paolo, E. D., Salaun, B., Kiran, P. S., & Folschweiller, N. (2019) · Journal of Viral Hepatitis · doi:10.1111/jvh.13125 · Cited by 47 · see citing works
ACG Clinical Guideline Update: Preventive Care in Inflammatory Bowel Disease
Farraye, F. A., Melmed, G., Lichtenstein, G. R., Barnes, E. L., Limketkai, B. N., Caldera, F., & Kane, S. V. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003541 · Cited by 44 · see citing works
Reduced immune responses to hepatitis B primary vaccination in obese individuals with nonalcoholic fatty liver disease (NAFLD)
Joshi, S. S., Davis, R. P., Ma, M. M., Tam, E., Cooper, C., Ramji, A. S., Kelly, E., Jayakumar, S., Swain, M. G., Jenne, C. N., et al. (2021) · npj Vaccines · doi:10.1038/s41541-020-00266-4 · Cited by 28 · see citing works
Duration of Hepatitis B Vaccine-Induced Protection among Medical Students and Healthcare Workers following Primary Vaccination in Infancy and Rate of Immunity Decline
Phattraprayoon, N., Kakheaw, J., Soonklang, K., Cheirsilpa, K., Ungtrakul, T., Auewarakul, C. U., & Mahanonda, N. (2022) · Vaccines · doi:10.3390/vaccines10020267 · Cited by 24 · see citing works
Revaccination against hepatitis B in late teenagers who received vaccination during infancy: Yes or no?
Zhao, H. L., & Zhou, Y. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1397243 · Cited by 23 · see citing works
CSOG MFM Committee Guideline: Management of Hepatitis B During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020)
Zhou, Y., Hu, Y., Liu, X., & Yang, H. (2021) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000087 · Cited by 22 · see citing works
Physicians’ Knowledge and Application of Immunization Strategies in Patients with Inflammatory Bowel Disease: A Survey of the Italian Group for the Study of Inflammatory Bowel Disease
Macaluso, F. S., Mazzola, G. C., Ventimiglia, M., Alvisi, P., Renna, S., Adamoli, L., Galli, M., Armuzzi, A., Ardizzone, S., Cascio, A., et al. (2019) · Digestion · doi:10.1159/000500798 · Cited by 20 · see citing works
Assessing the Cost-Utility of Universal Hepatitis B Vaccination Among Adults
Hall, E. W., Weng, M. K., Harris, A. M., Schillie, S. F., Nelson, N. P., Ortega‐Sanchez, I. R., Rosenthal, E. M., Sullivan, P. S., Lopman, B. A., Jones, J. S., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac088 · Cited by 18 · see citing works
Malaria vaccines: facing unknowns
Palacpac, N., & Horii, T. (2020) · F1000Research · doi:10.12688/f1000research.22143.1 · Cited by 17 · see citing works
Effectiveness of Hepatitis B Vaccination for Patients With Inflammatory Bowel and Celiac Disease
Ulrich, J. A., Habash, N. W., Ismail, Y., Tremaine, W. J., Weaver, A. L., Murray, J. A., Loftus, E. V., & Absah, I. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.03.025 · Cited by 16 · see citing works
Hepatitis B Outcomes After Switching to Long-Acting Cabotegravir/Rilpivirine in People With HIV: Reactivation, Incident Infection, and Liver Safety Across Diverse Serological Profiles
Foncillas, A., Ambrosioni, J., Sempere, A., Berrocal, L., Calvo, J., Chivite, I., de la Mora, L., Inciarte, A., Torres, B., Martínez‐Rebollar, M., et al. (2026) · Clinical Infectious Diseases · doi:10.1093/cid/ciag023 · Cited by 15 · see citing works
Discordance of hepatitis B vaccination policies for healthcare workers between the USA, the UK, and Germany
Komatsu, H., Klenerman, P., & Thimme, R. (2019) · Hepatology Research · doi:10.1111/hepr.13470 · Cited by 15 · see citing works
Hepatitis B seroprevalence in 10-25-year-olds in Mexico - the 2012 national health and nutrition survey (ENSANUT) results
López‐Gatell, H., García‐García, L., Echániz-Avilés, G., Cruz‐Hervert, L. P., Olamendi-Portugal, M., Castaneda, D., Sánchez-Alemán, M. Á., Martínez, M. R., DeAntonio, R., Cervantes-Apolinar, M. Y., et al. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1533617 · Cited by 15 · see citing works
From infancy and beyond… ensuring a lifetime of hepatitis B virus (HBV) vaccine-induced immunity
Osiowy, C. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1462428 · Cited by 15 · see citing works
Will Infant Hepatitis B Vaccination Protect Into Adulthood?
Pinto, M., Dawar, M., Krajden, M., Naus, M., & Scheifele, D. W. (2017) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001543 · Cited by 13 · see citing works
Disparities in Hepatitis B Virus Infection and Immunity Among New York City Asian American Patients, 1997 to 2017
Tang, A. S., Lyu, J., Wang, S., He, Q., Pong, P., & Harris, A. M. (2018) · American Journal of Public Health · doi:10.2105/ajph.2018.304504 · Cited by 13 · see citing works
Lasting benefit of infant hepatitis B vaccination in adolescents in the Lao People’s Democratic Republic
Hefele, L., Vannachone, S., Khounvisith, V., Nouanthong, P., Sayasone, S., Kounnavong, S., Chanthavilay, P., Muller, C. P., & Black, A. P. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.01.055 · Cited by 13 · see citing works
Observational study of vaccine effectiveness 20 years after the introduction of universal hepatitis B vaccination in Tunisia
Hadj, M. B., Bouguerra, H., Saffar, F., Chelly, S., Hechaichi, A., Talmoudi, K., Bahrini, A., Chouki, T., Hazgui, O., Hannachi, N., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.08.038 · Cited by 12 · see citing works
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro
Konopleva, M. V., Borisova, V. N., Sokolova, M. V., Семененко, Т. А., & Suslov, A. P. (2022) · Vaccines · doi:10.3390/vaccines10020235 · Cited by 12 · see citing works
Susceptibility to hepatitis B virus infection in adults living in Spain
Soriano, V., Aguilera, A., Benito, R., González‐Díez, R., Miró, E., Liendo, P., Rodrı́guez, J. C., Cabezas, T., Richart, A., Ramos, J. M., et al. (2023) · Liver International · doi:10.1111/liv.15548 · Cited by 11 · see citing works
Exploring the optimal vaccination strategy against hepatitis B virus in childhood (Review)
Kramvis, A., Mammas, I., & Spandidos, D. A. (2023) · Biomedical Reports · doi:10.3892/br.2023.1631 · Cited by 11 · see citing works
Incidences of new hepatitis B infection and anti‐hepatitis B core‐negative occult hepatitis B infection among Japanese blood donors in relation to anti‐hepatitis B surface antigen levels
Satake, M., Sugiyama, M., Mizokami, M., & Tanaka, J. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29823 · Cited by 9 · see citing works
Administering an additional hepatitis B vaccination dose after 18 years maintains adequate long-term protection levels in healthcare workers
Hess, L., Riesenberg, K., Rolston, K. V. I., & Nesher, L. (2020) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2020.1718201 · Cited by 9 · see citing works
Hepatitis B and pertussis antibodies in 4- to 5-year-old children previously vaccinated with different hexavalent vaccines
Vesikari, T., Xu, J. Z., Johnson, D. R., Hall, J. D., Marček, T., Goveia, M. G., Acosta, C. J., & Lee, A. W.-T. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1673119 · Cited by 9 · see citing works
Summary of the NACI Update on the Recommended Use of Hepatitis B Vaccine
Henry, B., & Baclic, O. (2017) · Canada Communicable Disease Report · doi:10.14745/ccdr.v43i05a04 · Cited by 8 · see citing works
Impact of universal infant hepatitis B vaccination in the US-affiliated Pacific Islands, 1985–2015
Abara, W. E., Collier, M. G., & Teshale, E. H. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.01.020 · Cited by 8 · see citing works
High Rates of Seroprotection to Hepatitis B After a Hepatitis B Challenge Dose in Previously Vaccinated Patients with Inflammatory Bowel Disease on Immunosuppressive Therapy
Ley, D., Lazarus, S. G., Forati, A. M., Farraye, F. A., Smith, R. A., Hayney, M. S., & Caldera, F. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08527-1 · Cited by 8 · see citing works
Will Infant Hepatitis B Immunization Protect Adults?
Scheifele, D. W. (2019) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002326 · Cited by 7 · see citing works
An Evidence-based Practical Guide to Vaccination for Hepatitis B Virus
Jacobson, I. M., Brown, R. S., McMahon, B. J., Perrillo, R. P., & Gish, R. G. (2022) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001695 · Cited by 7 · see citing works
Hepatitis B Virus in Polish Blood Donors in the Period 2005–2019—Significant Changes in Epidemiology and Demographic Characteristics of Infected Donors
Kopacz, A., Kubicka‐Russel, D., Liszewski, G., Sulkowska, E., Chrzanowska, A., Zwolińska, P., Noceń, E., Potępa, A., Łętowska, M., & Grabarczyk, P. (2025) · Viruses · doi:10.3390/v17010060 · Cited by 6 · see citing works
Minimal association of alleles of human leukocyte antigen class II gene and long-term antibody response to hepatitis B vaccine vaccinated during infancy
Xu, B., Zhu, D., Bi, Y., Wang, Y., Hu, Y., & Zhou, Y. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.03.021 · Cited by 6 · see citing works
Low Prevalence of Vaccination or Documented Immunity to Hepatitis A and Hepatitis B Viruses Among Individuals with Chronic Liver Disease
Wong, R. J., Gish, R. G., Cheung, R. C., & Chitnis, A. S. (2021) · The American Journal of Medicine · doi:10.1016/j.amjmed.2021.02.008 · Cited by 6 · see citing works
Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders
Vakili, M. E., Faghih, Z., Sarvari, J., Doroudchi, M., Hosseini, S. N., Kabelitz, D., & Kalantar, K. (2022) · Immunologic Research · doi:10.1007/s12026-022-09278-9 · Cited by 6 · see citing works
Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Tropical Medicine and Health · doi:10.1186/s41182-024-00594-4 · Cited by 6 · see citing works
Persistence of Anti-HB Antibodies in Healthcare Trainees: The Impact of Childhood Versus Adolescent Vaccination
Giampaolo, L. D., Coppeta, L., Borrelli, P., Astolfi, P., Resta, A., Loffredo, L., Bucchianico, F. D. M. D., Mangifesta, R., Ippoliti, L., & Ferrari, C. (2025) · Vaccines · doi:10.3390/vaccines13060562 · Cited by 5 · see citing works
Hepatitis B vaccination status in an at-risk adult population: long-term immunity but insufficient coverage
Hustache, S., Moyroud, L., Goirand, L., & Épaulard, O. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-2957-0 · Cited by 5 · see citing works
Hepatitis B Vaccines
Ward, J. W., Wanlapakorn, N., Poovorawan, Y., & Shouval, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00027-x · Cited by 5 · see citing works
Aplicación racional de las recomendaciones ESPGHAN 2022 de seguimiento del paciente celíaco pediátrico: documento de consenso de sociedades científicas (SEGHNP, AEPap, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG y SEMERGEN)
Román, E., Barrio, J., Cilleruelo, M. L., Torres, R., Almazán, V., Coronel, C., Espín, B., Martínez‐Ojinaga, E., Solís, D. P., Moreno, M. A. G., et al. (2024) · Anales de Pediatría · doi:10.1016/j.anpedi.2024.09.001 · Cited by 5 · see citing works
Towards the worldwide eradication of hepatitis B virus infection: A combination of prophylactic and therapeutic factors
Sagnelli, C., & Sagnelli, E. (2019) · World Journal of Clinical Infectious Diseases · doi:10.5495/wjcid.v9.i2.11 · Cited by 5 · see citing works
Clinical Trial: Immunogenicity of Double‐Dose Versus Standard‐Dose of Hepatitis B Virus Vaccine in Inflammatory Bowel Disease
Singh, A. K., Soni, R. K., Jearth, V., Yadav, A. I., Birda, C. L., Chatterjee, A., Shah, J., Mohindra, R., Patil, A. N., Suri, V., et al. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70470 · Cited by 4 · see citing works
Immune Responses to HBV Vaccine in People Living with HIV (PLWHs) Who Achieved Successful Treatment: A Prospective Cohort Study
Xu, L., Zhang, L., Kang, S., Li, X., Lu, L., Liu, X., Song, X., Li, Y., Li, X., Lyu, W., et al. (2023) · Vaccines · doi:10.3390/vaccines11020400 · Cited by 4 · see citing works
Induction of Innate and Adaptive Immune Response against Recombinant HBsAg Protein Entrapped in Docosahexaenoic Acid Nanovesicles through Biomarkers
Bakkari, M. A., Moni, S. S., Alshammari, A., Sultan, M. H., Madkhali, O. A. A., Almoshari, Y., Alam, M. F., & Elmobark, M. E. (2023) · Vaccines · doi:10.3390/vaccines11020457 · Cited by 4 · see citing works
Celiac Disease: Risk of Hepatitis B Infection.
Habash, N. W., Choung, R. S., Jacobson, R. M., Murray, J. A., & Absah, I. (2022) · PubMed · doi:10.1097/mpg.0000000000003362 · Cited by 3 · see citing works
Level of antibody to hepatitis B surface antigen declined below 10 mIU/ml is still protective
Shen, P., Xu, C., Li, T., Rui, Y., Hu, Y., Zhang, Y., & Zhou, Y. (2025) · npj Vaccines · doi:10.1038/s41541-025-01188-9 · Cited by 3 · see citing works
Demonstration of durable hepatitis B immune memory in children vaccinated with a DTaP5-IPV-HepB-Hib infant-toddler series 7 to 8 years previously
Ahonen, A., Zhang, Y., Marček, T., Lumley, J., Johnson, D. R., Güriş, D., & Wilck, M. B. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2073747 · Cited by 3 · see citing works
Post-vaccination Immunity Against Hepatitis B Among Mongolian Adolescents and Youths
Shagdarsuren, O.-E., Khuyagaa, S.-O., Mukhtar, Y., Mandakh, U., Enkh-Oyun, T., Shaarii, S., Batsuren, N., Namdag, B., Radnaa, O., & Dambadarjaa, D. (2022) · Hepatitis Monthly · doi:10.5812/hepatmon-121383 · Cited by 3 · see citing works
Vaginal Delivery and Breastfeeding Benefit Infant Immune Response to Hepatitis B Vaccine: A Prospective Cohort Study
Liu, H., Li, L., Li, Y., Liu, M., Song, Y., Ding, F., Zhang, X., & Li, J. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00032s · Cited by 3 · see citing works
Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09201-7 · Cited by 3 · see citing works
A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers
Kiertscher, S. M., Gangalum, P. R., Ibrahim, G., Tashkin, D. P., & Roth, M. D. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9776-7 · Cited by 3 · see citing works
Longitudinal mapping of hepatitis B vaccine‐induced B‐cell linear epitopes in healthy individuals
Zhong, S., Liu, Z., Zhou, Y., Zhang, T., Fu, X., Guo, L., Gu, S., Tang, L., Hou, J., & Li, Y. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27926 · Cited by 3 · see citing works
Health and economic impact of hepatitis B vaccination in the national immunization program in Belarus, Georgia, Kyrgyzstan, Republic of Moldova, Turkmenistan and Uzbekistan—a modelling study
Sadeghimehr, M., Mosina, L., Sim, S. Y., & Datta, S. S. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1567033 · Cited by 2 · see citing works
Analysis of the positive results and influencing factors of hepatitis B antibody in hospitalized neonates with AgHBs positive mothers
Min, Y. X., Gao, Y., Liu, C. T., Lu, X., & Chen, X. C. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1042435 · Cited by 2 · see citing works
Immune response and associated factors to Hepatitis B vaccination among children under five attending care at mulago hospital
Kimera, A., Rujumba, J., Ndikuno, C. K., Ndeezi, G., Mukiza, N., Basenero, A., Piloya, T., Bakeera‐Kitaka, S., Nabulya, R., Nalumansi, A. M., et al. (2025) · BMC Pediatrics · doi:10.1186/s12887-024-05366-x · Cited by 2 · see citing works
The Question of Protection: Hepatitis B Vaccine and Waning Antibody Levels
Grayer, D., & Jhaveri, R. R. (2025) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piaf044 · Cited by 2 · see citing works
Complementary Presence of HBV Humoral and T-cell Response Provides Protective Immunity after Neonatal Immunization
Huang, Y.-M., Yang, Y., Wu, T., Li, Z., Xu, H., Huang, A., & Zhao, Y. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00272 · Cited by 2 · see citing works
Inadequate Vaccine Responses in Children With Multiple Sclerosis
Santoro, J. D., Saucier, L. E., Tanna, R., Wiegand, S. E., Pagarkar, D., Tempchin, A. F., Khoshnood, M. M., Ahsan, N., & van Haren, K. P. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.790159 · Cited by 2 · see citing works
Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders
Vakili, M. E., Mashhadi, N., Ataollahi, M. R., Meri, S., Kabelitz, D., & Kalantar, K. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13402 · Cited by 1 · see citing works
Rational application of the ESPGHAN 2022 recommendations for the follow-up of the paediatric coeliac patient: consensus document of scientific societies (SEGHNP, AEPAP, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG and SEMERGEN)
Román, E., Barrio, J., Cilleruelo, M. L., Torres, R., Almazán, V., Coronel, C., Espín, B., Martínez‐Ojinaga, E., Solís, D. P., Moreno, M. A. G., et al. (2024) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2024.09.008 · Cited by 1 · see citing works
Hepatitis B Vaccine: Time to Rethink Our Correlate of Protection
Habash, N. W., & Absah, I. (2026) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2026.04.004 · Cited by 1 · see citing works
Evaluation of hepatitis B vaccination status and immune response among health care workers in a tertiary care hospital in western India
Mehta, T., & Parul, D. S. (2021) · Vacunas · doi:10.1016/j.vacun.2020.09.004 · Cited by 1 · see citing works
Loss of protective anti‐HBs titers and seroconversion to hepatitis B vaccination in children during chemotherapy for acute lymphoblastic leukemia
Prasanth, V. R., Thankamony, P., Rajeswari, B., Sojamani, G. C., Nair, M., Kusumakumary, P., & Krishna, K. M. J. (2022) · Pediatric Blood & Cancer · doi:10.1002/pbc.30154 · Cited by 1 · see citing works
Does co-administration of vaccines interfere with immune responses? The jury is still out
Mondelli, M. U. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.09.022 · Cited by 1 · see citing works
Good Practices and Initiatives for the Control and Elimination of Hepatitis B in the World: A Scoping Review
Jalal, M. A., Mohammed, L. M., Suraifi, M., Namdari, M., Lami, F., Taher, T. M. J., Anied, A. A., Etemad, K., & Karami, M. (2024) · Cureus · doi:10.7759/cureus.59785 · Cited by 1 · see citing works
Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen
Jan, C.-F. J., Liu, T., Ho, C. H., Chien, Y.-C., Chang, C.-J., Guo, F., & Huang, K. (2019) · Family Practice · doi:10.1093/fampra/cmz039 · Cited by 1 · see citing works
Long-Term Protection and Antibody Levels 35 Years after Primary Immunization Series with Hepatitis B Vaccine and Response to a Booster Dose in Those Persons Who Lost AntibodyPreprint
Bruce, M. G., Bruden, D. J. T., Hurlburt, D. A., Morris, J. M., Bressler, S. S., Thompson, G. G., Lecy, D., Rudolph, K. M., BULKOW, L. R., Hennessy, T., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3980547 · Cited by 1 · see citing works
Management of Acute Hepatitis B Virus Infection
Shiffman, M. L. (2020) · Current Hepatology Reports · doi:10.1007/s11901-020-00536-8
Gating strategy for plasmablast enumeration after hepatitis B vaccination
Byazrova, M. G., Топтыгина, А. П., Mitina, T. A., & Filatov, A. V. (2021) · Medical Immunology (Russia) · doi:10.15789/1563-0625-gsf-2066
Complementary Presence of HBV-Specific Humoral and T-Cellular Immune Response Provide the Long-Lasting Immune Protection After Neonatal ImmunizationPreprint
Huang, Y., Yang, Y., Wu, T., Li, Z., & Zhao, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-436535/v1
Table of Contents
(2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv738
Evaluation of hepatitis B vaccination status and immune response among health care workers in a tertiary care hospital in western India
Tanmay, K. M., & Parul, D. S. (2021) · Vacunas (English Edition) · doi:10.1016/j.vacune.2020.09.002
Hepatitis B Vaccines
Damme, P. V., & Vorsters, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-77173-7_13
Hepatitis B and Hepatitis D Viruses
Harris, A. M., & Schillie, S. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-75608-2.00213-5
Reply
Habash, N. W., & Abash, I. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.05.031
Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study
Hashem, M., Abdel-Haleem, H., Khairy, M., Nassef, A., Essam, M., & Desouky, E. D. E. (2023) · Microbes and Infectious Diseases /Microbes and Infectious Diseases · doi:10.21608/mid.2023.236668.1617
Comparison of Hepatitis B Surface Antibody Levels After Vaccination With Combined One Dose of Hexavalent Vaccine and Two Doses of Pentavalent Vaccine Versus Three Doses of Pentavalent Vaccine
Soonthornarrak, K., Limrungsikul, A., & Apiwattanakul, N. (2024) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000004449
Hepatitis B Virus Immunity Status and Booster Dose Efficacy in Health Sciences Students: An Interventional Study
Shokouh, S. J. H., Naseh, I., Barati, M., Gholami, M., & Farkhonderay, A. (2024) · Annals of Military and Health Sciences Research · doi:10.5812/amh-153329
Acute hepatitis B infections reported among appropriately vaccinated individuals, Philadelphia: A Role for Booster Doses?
Tan, M., Addish, E., Epstein, S., & Kuncio, D. E. (2025) · Vaccine X · doi:10.1016/j.jvacx.2025.100757
Booster Vaccination Against Invasive Pneumococcal Disease and Hepatitis B in Previously Vaccinated Solid Organ Transplant Recipients Without Seroprotection
Sejerøe-Olsen, J., Suarez‐Zdunek, M. A., Helbo, T., Hornung, L. B., Jørgensen, C. S., Rossing, K., Perch, M., Rasmussen, A., Hamm, S. R., & Nielsen, S. D. (2025) · Vaccines · doi:10.3390/vaccines13121253
Additional file 1 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.25422342
Additional file 3 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.26693907
Additional file 4 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.26693910
Additional file 1 of Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Figshare · doi:10.6084/m9.figshare.26700068
Additional file 3 of Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Figshare · doi:10.6084/m9.figshare.26700074
Additional file 2 of Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Figshare · doi:10.6084/m9.figshare.26700071
Additional file 2 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.25422405
Letter: Double‐Dose Hepatitis B Vaccination in IBD —A Step Forward in Protecting Immunosuppressed Patients. Authors' Reply
Singh, A. K., Birda, C. L., & Dutta, U. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70603
Baseline Hepatitis B Immunity and Vaccination Booster Response Among Medical Residents: A Longitudinal Study in a Spanish Tertiary Hospital
Salguero-Cano, V., Martínez, S. M., González-Alcaide, M., Valero-Ubierna, C., Martínez‐Ruiz, V., Rivera‐Izquierdo, M., & de Alba, I. G.-F. (2026) · Vaccines · doi:10.3390/vaccines14030280
Prevalence of hepatitis B surface antibodies and hepatitis B exposure in Belgium: results from a nationwide population-based serosurvey
d’Almeida, A. F., Ho, E., Beutels, P., Maertens, K., Hens, N., Damme, P. V., Theeten, H., & Vanwolleghem, T. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-13266-x
Serological evidence of hepatitis B virus exposure and vaccination coverage trends in health sciences students in Albania
Jaho, J., Balilaj, L., Bulla, A., Capraro, Y., Lamfu, L., & Baiocchi, L. (2026) · World Journal of Virology · doi:10.5501/wjv.v15.i2.118992
Long-term protection following a primary series of hepatitis B vaccine in Alaska Native children and adults
Steinberg, J., Blake, I., Stevenson, T. J., Wheelock, H., Bruden, D. J. T., Townshend‐Bulson, L., Klejka, J. A., Peterson, M., Cartwright, E. J., Drobeniuc, J., et al. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000978
Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations
Roldan, G. A., Fletcher, J., Davie, T., Leventhal, T. M., Lake, J. R., & Udompap, P. (2026) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2026.3831
Hepatitis B virus serological profiles, susceptibility and associated factors among adolescents in a conflict-affected district of Cameroon: a community-based cross-sectional studyPreprint
Yunika, L. K., Tanue, E. A., Ukah, C. E., Ngekeng, S., Afeseh, E., (22470271), S. Z. D., & Ekane, E. G. H. (2026) · Research Square · doi:10.21203/rs.3.rs-11078626/v1

Preliminary assessment of hepatitis B-specific cellular immunity amongst a longitudinal vaccine cohort demonstrates evidence of natural exposure. (VAC11P.1110)
Simons, B. C., Spradling, P. R., Zanis, C. L., Choromanski, T. L., Case, S. L., Bruce, M. G., Bruden, D. J. T., Murphy, T. V., Knall, C., & McMahon, B. J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.212.18
Long-term protection at 20–31 years after primary vaccination with plasma-derived hepatitis B vaccine in a Chinese rural community
Ma, J., Wu, Z., Zhou, H., Gao, Z., Hao, Z.-Y., Jin, F., Zhang, Y., Li, M.-J., Wang, F., Li, Q., et al. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1646575 · Cited by 19 · see citing works
The efficacy of hepatitis B vaccination program in upper Egypt: Flow cytometry and the evaluation of long term immunogenicity
Makhlouf, N. A., Farghaly, A. M., Zaky, S., Rashed, H. A. G., Faddan, N. H. A., Sayed, D. M., El‐Badawy, O., Afifi, N. M., Hamza, W. S., & El‐Sayed, Y. (2016) · Journal of Medical Virology · doi:10.1002/jmv.24506 · Cited by 11 · see citing works
Antibody levels and immune memory 23 years after primary plasma-derived hepatitis B vaccination: Results of a randomized placebo-controlled trial cohort from China where endemicity is high
Wu, Q., Zhuang, G., Wang, X., Wang, L., Li, N., & Zhang, M. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.01.025 · Cited by 52 · see citing works
Humoral and Cellular Immune Responses to a Hepatitis B Vaccine Booster 15–18 Years after Neonatal Immunization
Lu, C., Ni, Y., Chiang, B., Chen, P., Chang, M., Chang, L., Su, I., Kuo, H., Huang, L., Chen, D., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/587695 · Cited by 197 · see citing works

Authors: Simons, B. C., Spradling, P. R., Bruden, D. J. T., Zanis, C., Case, S., Choromanski, T. L., Apodaca, M., Brogdon, H. D., Dwyer, G., Snowball, M., Negus, S., Bruce, M. G., Morishima, C., Knall, C., & McMahon, B. J.
Affiliations: Centers for Disease Control and Prevention (US)
Alaska Native Tribal Health Consortium (US)
University of Washington (US)
University of Alaska Anchorage (US)
Corresponding author: Simons, Brenna C.
ORCID: Simons, Brenna C.
Spradling, Philip R.
Bruden, Dana J. T.
Case, Samantha
Dwyer, Gaelen
Bruce, Michael G.
Morishima, Chihiro
McMahon, Brian J.
Venue: Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2016-04-07
Volume: 214
Issue: 2
Pages: 273-280
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jiw142
PMC: PMC4918827
OpenAlex: W2359724621
Cited by: 101
References: 50
Citations by year: 2026: 10 · 2025: 10 · 2024: 16 · 2023: 10 · 2022: 16 · 2021: 12 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 1
FWCI: 6.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Infectious Diseases (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: CDC (U01 PS001097)
National Institute of General Medical Sciences
National Institutes of Health
NIH (P20GM103395, U261IHS0046)
Topics: Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
Keywords: hepatitis B vaccine, hepatitis B virus, cell-mediated immunity, hepatitis B surface antigen, HBV core antigen, NKT cells, cytokine production, miR-155, plasma-derived vaccine
MeSH terms: Adult, Cytological Techniques, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Immunity, Cellular, Longitudinal Studies, Male, Middle Aged, T-Lymphocytes, Time Factors, Hepatitis B Vaccines, MicroRNAs, Enzyme-Linked Immunospot Assay

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks