HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth hormone

Mellado, Mario; Llorente, Mercedes; Rodríguez-Frade, J.Miguel; Lucas, Pilar; Martínez-A, Carlos; del Real, Gustavo

doi:10.1016/s0264-410x(98)80106-0

Cited by 26HIV Research and TreatmentT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth hormone

Mellado, Mario, Llorente, Mercedes, Rodríguez-Frade, J.Miguel, Lucas, Pilar, Martínez-A, Carlos, del Real, Gustavo·1998·Vaccine

DOI 10.1016/s0264-410x(98)80106-0

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Abstract

Immunization of mice with HIV-1-gp120 results in predominant activation of the Th2 lymphocyte subset, leading to enhanced IL-4 production. Administration of human growth hormone at the time of gp120 immunization provokes a change in the cytokine production pattern, with lower IL-4 and higher gamma-IFN and IL-2 synthesis levels, indicating a preferential switch in stimulation from Th2 to Th1 cells. A growth hormone would thus be of great use for pharmacological intervention in those cases in which an infectious microorganism evades immune defenses by provoking a Th2 response. In addition, the ability of growth hormone to induce a Th1-type response upon vaccination with an HIV-antigen should be examined in the development of new therapeutic strategies or in the design of novel vaccines against HIV infection.

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Inflammatory reactivity could potentially be altered by sleep disturbances.
“inflammatory reactivity could potentially be altered by sleep disturbances”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [379]
The HPA axis, which is crucial in suppressing inflammatory processes, might become impaired by (prolonged) sleep loss.
“the HPA axis, which is crucial in suppressing inflammatory processes, might become impaired by (prolonged) sleep loss”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [379]

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Authors: Mellado, M., Llorente, M., Rodríguez-Frade, J. M., Lucas, P., Martínez-A, C., & del Real, G.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Mellado, Mario
Llorente, Mercedes
Venue: Vaccine
Publisher: Elsevier BV
Published: 1998-07
Volume: 16
Issue: 11-12
Pages: 1111-1115
ISSN: 0264-410X (ISSN-L)
DOI: 10.1016/s0264-410x(98)80106-0
OpenAlex: W2076757912
Cited by: 26
References: 34
Citations by year: 2024: 1 · 2020: 1 · 2019: 1 · 2013: 2 · 2012: 1
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Vaccine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: HIV-1, gp120, Th2 immune response, Th1 response, human growth hormone, IL-4, interferon-gamma, interleukin-2, cytokine production, HIV vaccine, immunomodulation, T helper cell differentiation
MeSH terms: Animals, Immunization, Mice, Inbred BALB C, Stimulation, Chemical, HIV Envelope Protein gp120, Interleukin-4, Th1 Cells, Th2 Cells, Human Growth Hormone, Mice

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HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth hormone

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