The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Recent advances in IL-22 biology
Abstract
Several cell types, in particular epithelial cells, express the receptor for the cytokine IL-22 and upon its recognition produce molecules that are active both locally and systemically. Many different types of lymphocyte secrete IL-22. T(h)17 cells produce IL-22 although the optimal conditions for secretion of IL-17 or IL-22 by T(h)17 cells differ, as do the transcription factors involved. Aryl hydrocarbon receptor is required for IL-22 production by T(h)17, T(h)22 and γδ T cells. T(h)22 cells produce IL-22 in response to IL-6 and tumor necrosis factor α (TNF-α), particularly in the skin, whereas γδ T cells produce IL-22 in response to IL-23, particularly in the lung. NK cells produce IL-22 in response to IL-12 and IL-18 or IL-23. Retinoic acid-related orphan receptorγt-positive innate lymphoid cells, including lymphoid tissue inducer (LTi) and LTi-like cells express IL-22 with IL-23 again enhancing expression. IL-22 is known to be expressed in many chronic inflammatory conditions, including psoriasis and rheumatoid arthritis, and its up-regulation often correlates with disease activity. IL-22 is known to be protective in the gastrointestinal tract in inflammatory bowel disease but may mediate either harmful or helpful inflammatory responses in different models of intestinal infection. Finally, IL-22 may also play an important role in tissue repair.
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Cites
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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
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IL-22 is involved in liver regeneration after hepatectomy
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Cited by
Role of the microbiota in immunity and inflammation.
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The aryl hydrocarbon receptor: multitasking in the immune system
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Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia
Gauguet, S., D'Ortona, S., Ahnger-Pier, K., Duan, B., Surana, N. K., Lu, R., Cywes-Bentley, C., Gadjeva, M., Shan, Q., Priebe, G. P., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00037-15 · Cited by 208
Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS
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Metadata
- Authors
- Zenewicz, L. A., & Flavell, R. A.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 23
- Issue
- 3
- Pages
- 159-163
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2112220475
- Cited by
- 333
- References
- 10
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- closed
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