Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia
Open accessAbstract
Th17 immunity in the gastrointestinal tract is regulated by the intestinal microbiota composition, particularly the presence of segmented filamentous bacteria (sfb), but the role of the intestinal microbiota in pulmonary host defense is not well explored. We tested whether altering the gut microbiota by acquiring sfb influences the susceptibility to staphylococcal pneumonia via induction of type 17 immunity. Groups of C57BL/6 mice which differed in their intestinal colonization with sfb were challenged with methicillin-resistant Staphylococcus aureus in an acute lung infection model. Bacterial burdens, bronchoalveolar lavage fluid (BALF) cell counts, cell types, and cytokine levels were compared between mice from different vendors, mice from both vendors after cohousing, mice given sfb orally prior to infection, and mice with and without exogenous interleukin-22 (IL-22) or anti-IL-22 antibodies. Mice lacking sfb developed more severe S. aureus pneumonia than mice colonized with sfb, as indicated by higher bacterial burdens in the lungs, lung inflammation, and mortality. This difference was reduced when sfb-negative mice acquired sfb in their gut microbiota through cohousing with sfb-positive mice or when given sfb orally. Levels of type 17 immune effectors in the lung were higher after infection in sfb-positive mice and increased in sfb-negative mice after acquisition of sfb, as demonstrated by higher levels of IL-22 and larger numbers of IL-22(+) TCRβ(+) cells and neutrophil…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SFB-deficient animals have increased lung bacterial burdens and more severe pneumonia when challenged with MRSA, which was associated with decreased IL-17-mediated responses in the lung.
“SFB-deficient animals have increased lung bacterial burdens and more severe pneumonia when challenged with methicillin-resistant Staphylococcus aureus (MRSA) (54), which was associated with decreased IL-17-mediated responses in the lung.”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [54]
Cites
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · see citing works
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,910 · see citing works
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works
Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works
Microbiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019378108 · Cited by 1,502 · see citing works
IL-22 Increases the Innate Immunity of Tissues
Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,362 · see citing works
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
Aujla, S. J., Chan, Y. R., Zheng, M., Fei, M., Askew, D. J., Pociask, D. A., Reinhart, T. A., McAllister, F. M., Edeal, J., Gaus, K., et al. (2008) · Nature Medicine · doi:10.1038/nm1710 · Cited by 1,162 · see citing works
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40202 · Cited by 1,052 · see citing works
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., & Sallusto, F. (2012) · Nature · doi:10.1038/nature10957 · Cited by 919 · see citing works
Lockhart, E., Green, A. M., & Flynn, J. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4662 · Cited by 767 · see citing works
Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525 · see citing works
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology · doi:10.1186/gb-2013-14-7-r82 · Cited by 507 · see citing works
Dantes, R. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.10423 · Cited by 452 · see citing works
Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells
de Beaucoudrey, L., Puel, A., Filipe‐Santos, O., Cobat, A., Ghandil, P., Chrabieh, M., Feinberg, J. M., von Bernuth, H., Samarina, A., Jannière, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080321 · Cited by 438 · see citing works
Interleukin‐6 Gene‐Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia
van der Poll, T., Keogh, C. V., Guirao, X., Buurman, W. A., Köpf, M., & Lowry, S. F. (1997) · The Journal of Infectious Diseases · doi:10.1086/514062 · Cited by 382 · see citing works
Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., & Setoyama, H. (1995) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1995.tb02242.x · Cited by 346 · see citing works
Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice.
Kudva, A., Scheller, E. V., Robinson, K. M., Crowe, C. R., Choi, S. M., Slight, S. R., Khader, S. A., Dubin, P. J., Enelow, R. I., Kolls, J. K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002194 · Cited by 346 · see citing works
Recent advances in IL-22 biology
Zenewicz, L. A., & Flavell, R. A. (2011) · International Immunology · doi:10.1093/intimm/dxr001 · Cited by 333 · see citing works
Pneumonia Caused by Methicillin‐Resistant Staphylococcus aureus
Rubinstein, E., Kollef, M. H., & Nathwani, D. (2008) · Clinical Infectious Diseases · doi:10.1086/533594 · Cited by 313 · see citing works
Wu, Q., Martin, R. J., Rino, J. G., Breed, R., Torres, R. M., & Chu, H. W. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.10.012 · Cited by 301 · see citing works
Fagundes, C. T., Amaral, F. A., Vieira, A. T., Soares, A. C., Pinho, V., Nicoli, J. R., Vieira, L. Q., Teixeira, M. M., & Souza, D. G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101682 · Cited by 244 · see citing works
Minegishi, Y., Saitō, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082767 · Cited by 242 · see citing works
γδ T cells protect against lung fibrosis via IL-22
Simonian, P. L., Wehrmann, F., Roark, C. L., Born, W. K., O’Brien, R. L., & Fontenot, A. P. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100061 · Cited by 239 · see citing works
Clarke, T. B. (2014) · Infection and Immunity · doi:10.1128/iai.02212-14 · Cited by 189 · see citing works
Cheng, M., Qian, L., Shen, G., Bian, G., Xu, T., Xu, W., Shen, G., & Hu, S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2462 · Cited by 182 · see citing works
IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?
Camporeale, A. (2012) · Frontiers in bioscience · doi:10.2741/4054 · Cited by 175 · see citing works
Interleukin-17-dependent CXCL13 mediates mucosal vaccine–induced immunity against tuberculosis
Gopal, R., Rangel‐Moreno, J., Slight-Webb, S. R., Lin, Y., Nawar, H. F., Junecko, B. A. F., Reinhart, T. A., Kolls, J. K., Randall, T. D., Connell, T. D., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2012.135 · Cited by 167 · see citing works
Segmented filamentous bacteria take the stage
Ivanov, I. I., & Littman, D. R. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.3 · Cited by 166 · see citing works
Maele, L. V., Carnoy, C., Cayet, D., Ivanov, S., Porte, R., Deruy, E., Chabalgoity, J. A., Renauld, J., Eberl, G., Benecke, A., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu106 · Cited by 166 · see citing works
Robinson, K. M., McHugh, K. J., Mandalapu, S., Clay, M. E., Lee, B., Scheller, E. V., Enelow, R. I., Chan, Y. R., Kolls, J. K., & Alcorn, J. F. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit527 · Cited by 131 · see citing works
Th17-stimulating Protein Vaccines Confer Protection against Pseudomonas aeruginosa Pneumonia
Wu, W., Huang, J., Duan, B., Traficante, D. C., Hong, H., Risech, M., Lory, S. J., & Priebe, G. P. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0182oc · Cited by 124 · see citing works
Self-citationPriebe, G. P., Walsh, R. L., Cederroth, T., Kamei, A., Coutinho-Sledge, Y. S., Goldberg, J. B., & Pier, G. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4965 · Cited by 121 · see citing works
Self-citationWu, S., Jiang, Z.-Y., Sun, Y.-F., Yu, B., Chen, J., Dai, C.-Q., Wu, X.-L., Tang, X.-L., & Chen, X.-Y. (2013) · Current Microbiology · doi:10.1007/s00284-013-0380-z · Cited by 116 · see citing works
Tsai, H., Velichko, S., Hung, L.-Y., & Wu, R. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/267971 · Cited by 114 · see citing works
Choi, S.-M., McAleer, J. P., Zheng, M., Pociask, D. A., Kaplan, M. H., Qin, S., Reinhart, T. A., & Kolls, J. K. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20120260 · Cited by 113 · see citing works
Chen, L.-W., Chen, P.-H., & Hsu, C.-M. (2011) · Shock · doi:10.1097/shk.0b013e3182184ee7 · Cited by 104 · see citing works
Incidence, characteristics and outcomes of patients with severe community acquired-MRSA pneumonia
Vardakas, K. Z., Matthaiou, D. K., & Falagas, M. E. (2009) · European Respiratory Journal · doi:10.1183/09031936.00041009 · Cited by 104 · see citing works
Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia
Cheng, P., Liu, T., Zhou, W., Zhuang, Y., Peng, L., Zhang, J., Yin, Z., Mao, X., Guo, G., Shi, Y., et al. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-38 · Cited by 97 · see citing works
Early production of IL-17 protects against acute pulmonaryPseudomonas aeruginosainfection in mice
Liu, J., Feng, Y., Yang, K., Li, Q. Y., Ye, L., Han, L., & Wan, H. (2010) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2010.00764.x · Cited by 84 · see citing works
Cooke, K. R., Hill, G. R., Gerbitz, A., Kobzik, L., Martin, T. R., Crawford, J. M., Brewer, J. P., & Ferrara, J. L. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6612 · Cited by 78 · see citing works
Zhou, X., Chen, Q., Moore, J., Kolls, J. K., Halperin, S. A., & Wang, J. (2009) · Infection and Immunity · doi:10.1128/iai.00403-09 · Cited by 65 · see citing works
Chewning, J. H., & Weaver, C. T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401835 · Cited by 61 · see citing works
Fox, A. C., McConnell, K. W., Yoseph, B. P., Breed, E. R., Liang, Z., Clark, A. T., O’Donnell, D., Zee-Cheng, B. R., Jung, E., Dominguez, J. A., et al. (2012) · Shock · doi:10.1097/shk.0b013e31826e47e8 · Cited by 59 · see citing works
Wolf, K., Plano, G. V., & Fields, K. A. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01290.x · Cited by 46 · see citing works
Host Response Signature to Staphylococcus aureus Alpha-Hemolysin Implicates Pulmonary Th17 Response
Frank, K. M., Zhou, T., Moreno‐Vinasco, L., Hollett, B., Garcia, J. G. N., & Wardenburg, J. B. (2012) · Infection and Immunity · doi:10.1128/iai.00191-12 · Cited by 38 · see citing works
Li, L., SHI, Q.-G., Lin, F., LIANG, Y.-G., Sun, L., Mu, J., WANG, Y.-G., SU, H.-B., Xu, B., Ji, C., et al. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1898 · Cited by 31 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The immunopathology of sepsis and potential therapeutic targets
van der Poll, T., van de Veerdonk, F. L., Scicluna, B. P., & Netea, M. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.36 · Cited by 1,957 · see citing works
Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606 · see citing works
Enaud, R., Prével, R., Ciarlo, E., Beaufils, F., Wieërs, G., Guery, B. P., & Delhaès, L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00009 · Cited by 762 · see citing works
Kumar, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01722 · Cited by 699 · see citing works
Homeostasis of the gut barrier and potential biomarkers
Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F. J., Cani, P. D., Théodorou, V., Dekker, J. P., Méheust, A., de Vos, W. M., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2015 · Cited by 616 · see citing works
The influence of the microbiome on respiratory health
Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611 · see citing works
Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia.
Hanada, S., Pirzadeh, M., Carver, K. Y., & Deng, J. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02640 · Cited by 495 · see citing works
Translocation and dissemination of commensal bacteria in post-stroke infection
Stanley, D., Mason, L. J., Mackin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4194 · Cited by 464 · see citing works
The role of the lung microbiota and the gut–lung axis in respiratory infectious diseases
Dumas, A., Bernard, L., Poquet, Y., Lugo-Villarino, G., & Neyrolles, O. (2018) · Cellular Microbiology · doi:10.1111/cmi.12966 · Cited by 444 · see citing works
Lung microbiome: new insights into the pathogenesis of respiratory diseases
Li, R., Li, J., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01722-y · Cited by 466 · see citing works
The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases
Zhang, D., Li, S., Wang, N., Tan, H., Zhang, Z., & Feng, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00301 · Cited by 437 · see citing works
The microbiota protects against respiratory infection via GM-CSF signaling
Brown, R. L., Sequeira, R. P., & Clarke, T. B. (2017) · Nature Communications · doi:10.1038/s41467-017-01803-x · Cited by 378 · see citing works
The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease
O’Dwyer, D. N., Dickson, R. P., & Moore, B. B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600279 · Cited by 362 · see citing works
Sencio, V., Machado, M. G., & Trottein, F. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00361-8 · Cited by 315 · see citing works
The Gut Microbiota and Respiratory Diseases: New Evidence
Li, C., Haiyue, L., Yanxia, L., Jianbing, P., & Su, J. (2020) · Journal of Immunology Research · doi:10.1155/2020/2340670 · Cited by 267 · see citing works
Contributions of the intestinal microbiome in lung immunity
McAleer, J. P., & Kolls, J. K. (2018) · European Journal of Immunology · doi:10.1002/eji.201646721 · Cited by 243 · see citing works
Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma
Mathieu, E., Escribano-Vázquez, U., Descamps, D., Cherbuy, C., Langella, P., Riffault, S., Rémot, A., & Thomas, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01168 · Cited by 233 · see citing works
Protective Microbiota: From Localized to Long-Reaching Co-Immunity
Chiu, L., Bazin, T., Truchetet, M., Schaeverbeke, T., Delhaès, L., & Pradeu, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01678 · Cited by 192 · see citing works
Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease
Raftery, A. L., Tsantikos, E., Harris, N. L., & Hibbs, M. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02144 · Cited by 178 · see citing works
Commensal Bacteria: An Emerging Player in Defense Against Respiratory Pathogens
Khan, R. S., Petersen, F. C., & Shekhar, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01203 · Cited by 160 · see citing works
Innate immune responses in the ageing lung.
Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156 · see citing works
The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
Hu, Y., Feng, Y., Wu, J., Liu, F., Zhang, Z., Hao, Y., Liang, S., Li, B., Li, J., Lv, N., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00090 · Cited by 154 · see citing works
Microbiome dysbiosis in lung cancer: from composition to therapy
Liu, N., Ma, Q., Ge, Y., Yi, C., Wei, L., Tan, J.-C., Chu, Q., Li, J., Zhang, P., & Wang, H. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-00138-z · Cited by 145 · see citing works
Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases
Saint‐Criq, V., Lugo‐Villarino, G., & Thomas, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101235 · Cited by 143 · see citing works
Contact lens-related corneal infection: Intrinsic resistance and its compromise
Fleiszig, S. M. J., Kroken, A. R., Nieto, V., Grosser, M. R., Wan, S. J., Metruccio, M. M. E., & Evans, D. J. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100804 · Cited by 140 · see citing works
Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis
Kugadas, A., Christiansen, S. H., Sankaranarayanan, S., Surana, N. K., Gauguet, S., Kunz, R. C., Fichorova, R. N., Vorup‐Jensen, T., & Gadjeva, M. G. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005855 · Cited by 134 · see citing works
Self-citationSymbiont-induced odorant binding proteins mediate insect host hematopoiesis
Benoit, J. B., Vigneron, A., Broderick, N. A., Wu, Y., Sun, J. S., Carlson, J. R., Aksoy, S., & Weiss, B. L. (2017) · eLife · doi:10.7554/elife.19535 · Cited by 129 · see citing works
Xu, L., Zhang, Y., Li, X., Li, C., Hu, H., Hu, J., Liu, M., Yang, Q. Z., Gu, P., Li, J., et al. (2025) · iMeta · doi:10.1002/imt2.270 · Cited by 138 · see citing works
Dumas, A., Corral, D., Colom, A., Levillain, F., Peixoto, A., Hudrisier, D., Poquet, Y., & Neyrolles, O. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02656 · Cited by 130 · see citing works
The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries
Hanna, B. S., Wang, G., Galván-Peña, S., Mann, A. O., Ramirez, R. N., Muñoz-Rojas, A. R., Smith, K., Wan, M., Benoist, C., & Mathis, D. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.033 · Cited by 126 · see citing works
Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome
McAleer, J. P., Nguyen, N. L. H., Chen, K., Kumar, P., Ricks, D. M., Binnie, M., Armentrout, R., Pociask, D. A., Hein, A., Yu, A. C., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502566 · Cited by 126 · see citing works
Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection
Håkansson, A., Orihuela, C. J., & Bogaert, D. (2018) · Physiological Reviews · doi:10.1152/physrev.00040.2016 · Cited by 126 · see citing works
Host–Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization
Mulcahy, M. E., & McLoughlin, R. M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.06.012 · Cited by 113 · see citing works
Flannigan, K. L., & Denning, T. L. (2018) · Immunology · doi:10.1111/imm.12950 · Cited by 111 · see citing works
Staphylococcal trafficking and infection—from ‘nose to gut’ and back
Raineri, E. J. M., Altulea, D., & van Dijl, J. M. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab041 · Cited by 110 · see citing works
The microbiota in pneumonia: From protection to predisposition
Thibeault, C., Suttorp, N., & Opitz, B. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba0501 · Cited by 108 · see citing works
The regulation of host defences to infection by the microbiota
Brown, R. L., & Clarke, T. B. (2016) · Immunology · doi:10.1111/imm.12634 · Cited by 103 · see citing works
Huang, R., Cai, G.-Q., Li, J., Li, X., Liu, H., Shang, X., Zhou, J., Nie, X., & Gui, R. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00978-2 · Cited by 103 · see citing works
Human skin commensals augment Staphylococcus aureus pathogenesis
Boldock, E., Surewaard, B. G. J., Shamarina, D., Na, M., Fei, Y., Ali, A. M., Williams, A., Pollitt, E. J. G., Szkuta, P. T., Morris, P., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0198-3 · Cited by 103 · see citing works
Role of the microbiome in swine respiratory disease
Niederwerder, M. C. (2017) · Veterinary Microbiology · doi:10.1016/j.vetmic.2017.02.017 · Cited by 103 · see citing works
COPD and Gut–Lung Axis: How Microbiota and Host Inflammasome Influence COPD and Related Therapeutics
Qu, L., Cheng, Q., Wang, Y., Mu, H., & Zhang, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.868086 · Cited by 104 · see citing works
Characterization of Gut Microbiota in Children With Pulmonary Tuberculosis
Li, W., Zhu, Y., Liao, Q., Wang, Z., & Wan, C. (2019) · BMC Pediatrics · doi:10.1186/s12887-019-1782-2 · Cited by 94 · see citing works
Segmented filamentous bacteria, Th17 inducers and helpers in a hostile world
Schnupf, P., Gaboriau‐Routhiau, V., Sansonetti, P. J., & Cerf–Bensussan, N. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.03.004 · Cited by 94 · see citing works
Gut microbiota and systemic immunity in health and disease
Lo, B. C., Chen, G., Núñez, G., & Caruso, R. (2020) · International Immunology · doi:10.1093/intimm/dxaa079 · Cited by 86 · see citing works
Tian, X., Hellman, J., Horswill, A. R., Crosby, H. A., Francis, K. P., & Prakash, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00159 · Cited by 84 · see citing works
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
Perdijk, O., Azzoni, R., & Marsland, B. J. (2023) · Physiological Reviews · doi:10.1152/physrev.00020.2023 · Cited by 88 · see citing works
Commensal bacteria in the upper respiratory tract regulate susceptibility to infection
Clark, S. E. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.03.010 · Cited by 81 · see citing works
Linking microbiota and respiratory disease
Hauptmann, M., & Schaible, U. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12421 · Cited by 75 · see citing works
Li, K.-L., Wang, B., Li, Z., Li, Y., & Liang, J. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00248-0 · Cited by 77 · see citing works
Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae
Samuelson, D. R., Shellito, J. E., Maffei, V. J., Tague, E. D., Campagna, S. R., Blanchard, E., Luo, M., Taylor, C. M., Ronis, M. J. J., Molina, P. E., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006426 · Cited by 75 · see citing works
Characteristic gut microbiota and metabolic changes in patients with pulmonary tuberculosis
Wang, S., Yang, L., Hu, H., Lv, L., Ji, Z., Zhao, Y., Zhang, H., Xu, M., Fang, R., Zheng, L., et al. (2021) · Microbial Biotechnology · doi:10.1111/1751-7915.13761 · Cited by 70 · see citing works
Microbiome of HIV-infected people
Dubourg, G., Surénaud, M., Lévy, Y., Hüe, S., & Raoult, D. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.05.015 · Cited by 68 · see citing works
Staphylococcus aureus Infections and Human Intestinal Microbiota
Liu, A., Garrett, S., Hong, W., & Zhang, J. (2024) · Pathogens · doi:10.3390/pathogens13040276 · Cited by 72 · see citing works
The role of microbiota in respiratory health and diseases, particularly in tuberculosis
Shah, T., Shah, Z., Baloch, Z., & Cui, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112108 · Cited by 70 · see citing works
Role of the Microbiome in Interstitial Lung Diseases
Chioma, O. S., Hesse, L. E., Chapman, A., & Drake, W. P. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.595522 · Cited by 64 · see citing works
Mulcahy, M. E., Leech, J. M., Renauld, J.-C., Mills, K. H., & McLoughlin, R. M. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.24 · Cited by 58 · see citing works
Stricker, S., Hain, T., Chao, C., & Rudloff, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126791 · Cited by 60 · see citing works
Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics
Shi, C. Y., Yu, C.-H., Yu, W. Y., & Ying, H. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/9278441 · Cited by 58 · see citing works
Chen, L., Zhang, G., Li, G., Wang, W., Ge, Z., Yang, Y., He, X., Liu, Z., Zhang, Z., Mai, Q., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00547-3 · Cited by 60 · see citing works
Gut microbiota and host defense in critical illness
Jacobs, M. C., Haak, B. W., Hugenholtz, F., & Wiersinga, W. J. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000424 · Cited by 59 · see citing works
The Intriguing Connection Between the Gut and Lung Microbiomes
Druszczyńska, M., Sadowska, B., Kulesza, J., Gąsienica-Gliwa, N., Kulesza, E., & Fol, M. (2024) · Pathogens · doi:10.3390/pathogens13111005 · Cited by 59 · see citing works
Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
Couter, C. J., & Surana, N. K. (2016) · Journal of Visualized Experiments · doi:10.3791/54114 · Cited by 56 · see citing works
Self-citationThe lung-gut crosstalk in respiratory and inflammatory bowel disease
Du, B., Fu, Y., Han, Y., Sun, Q., Xu, J., Yang, Y., & Rong, R. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1218565 · Cited by 52 · see citing works
Tian, X., Hellman, J., Horswill, A. R., Crosby, H. A., Francis, K. P., & Prakash, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00518 · Cited by 54 · see citing works
Staphylococcus aureus Host Tropism and Its Implications for Murine Infection Models
Mrochen, D. M., de Oliveira, L. M. F., Raafat, D., & Holtfreter, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197061 · Cited by 53 · see citing works
Gut Microbiome and Organ Fibrosis
Costa, C. F. F. A., Sampaio‐Maia, B., Araújo, R., Nascimento, D. S., Ferreira‐Gomes, J., Pestana, M., Azevedo, M. J., & Alencastre, I. S. (2022) · Nutrients · doi:10.3390/nu14020352 · Cited by 51 · see citing works
Long-distance microbial mechanisms impacting cancer immunosurveillance
Zitvogel, L., Fidelle, M., & Kroemer, G. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.020 · Cited by 51 · see citing works
The gut microbiota as a modulator of innate immunity during melioidosis
Lankelma, J. M., Birnie, E., Weehuizen, T. A. F., Scicluna, B. P., Belzer, C., Houtkooper, R. H., Roelofs, J. J. T. H., de Vos, A. F., van der Poll, T., Budding, A. E., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005548 · Cited by 50 · see citing works
Traumatic Spinal Cord Injury and the Gut Microbiota: Current Insights and Future Challenges
Jogia, T., & Ruitenberg, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00704 · Cited by 51 · see citing works
The use of fecal microbiota transplant in sepsis
Keskey, R. C., Cone, J., DeFazio, J. R., & Alverdy, J. C. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.002 · Cited by 51 · see citing works
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment
Sun, M., Lu, F., Yu, D., Wang, Y., Chen, P., & Liu, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1358597 · Cited by 52 · see citing works
Barthélémy, A., Sencio, V., Soulard, D., Deruyter, L., Faveeuw, C., Goffic, R. L., & Trottein, F. (2018) · Infection and Immunity · doi:10.1128/iai.00706-17 · Cited by 48 · see citing works
Schlechte, J., Skalosky, I., Geuking, M. B., & McDonald, B. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00539-2 · Cited by 47 · see citing works
Respiratory microbiota and lower respiratory tract disease
Lanaspa, M., Bassat, Q., Medeiros, M. M., & Muñoz‐Almagro, C. (2017) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1349609 · Cited by 47 · see citing works
Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
Zhu, W., Wu, Y., Liu, H., Jiang, C., & Huo, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741233 · Cited by 46 · see citing works
Coronavirus disease 2019 and the gut–lung axis
Zhou, D. D., Wang, Q., & Liu, H. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.09.013 · Cited by 45 · see citing works
Modulation of the gut microbiota to improve innate resistance
Schnupf, P., Gaboriau‐Routhiau, V., & Cerf–Bensussan, N. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.08.003 · Cited by 46 · see citing works
Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections
Mindt, B. C., & DiGiandomenico, A. (2022) · Antibiotics · doi:10.3390/antibiotics11040474 · Cited by 44 · see citing works
Weil’s Disease—Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota
Petakh, P., Isevych, V., Kamyshnyi, O., & Oksenych, V. (2022) · Biomolecules · doi:10.3390/biom12121830 · Cited by 41 · see citing works
Considering the ‘Alternatives’ for Next-Generation Anti-Staphylococcus aureus Vaccine Development
O’Brien, E. C., & McLoughlin, R. M. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.010 · Cited by 41 · see citing works
The role of gut-lung axis in COPD: Pathogenesis, immune response, and prospective treatment
Song, Z., Meng, Y., Fricker, M., Li, X., Tian, H., Tan, Y., & Qin, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30612 · Cited by 42 · see citing works
Microbiote intestinal et développement du système immunitaire
Gaboriau‐Routhiau, V., & Cerf–Bensussan, N. (2016) · médecine/sciences · doi:10.1051/medsci/20163211011 · Cited by 40 · see citing works
Intestinal barrier dysfunction as a key driver of severe COVID-19
Tsounis, E. P., Triantos, C. K., Konstantakis, C., Marangos, M. N., & Assimakopoulos, S. F. (2023) · World Journal of Virology · doi:10.5501/wjv.v12.i2.68 · Cited by 39 · see citing works
Multidrug resistant (or antimicrobial-resistant) pathogens - alternatives to new antibiotics?
Brunel, A.-S., & Guery, B. P. (2017) · Swiss Medical Weekly · doi:10.4414/smw.2017.14553 · Cited by 38 · see citing works
Ahn, D. S., & Prince, A. S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00300 · Cited by 38 · see citing works
How does the microbiota control systemic innate immunity?
Jordan, C. K. I., & Clarke, T. B. (2024) · Trends in Immunology · doi:10.1016/j.it.2023.12.002 · Cited by 37 · see citing works
Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice
Pires, S., Peignier, A., Seto, J., Smyth, D. S., & Parker, D. (2020) · JCI Insight · doi:10.1172/jci.insight.132223 · Cited by 38 · see citing works
Effect of antibiotic gut microbiota disruption on LPS-induced acute lung inflammation
Jacobs, M. C., Lankelma, J. M., Wolff, N. S., Hugenholtz, F., de Vos, A. F., van der Poll, T., & Wiersinga, W. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241748 · Cited by 37 · see citing works
Vendor effects on murine gut microbiota influence experimental abdominal sepsis
Hilbert, T., Steinhagen, F., Senzig, S., Cramer, N., Bekeredjian‐Ding, I., Parčina, M., Baumgarten, G., Hoeft, A., Frede, S., Boehm, O., et al. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.12.008 · Cited by 35 · see citing works
Felix, K. M., Jaimez, I. A., Nguyen, T. V., Ma, H., Raslan, W. A., Klinger, C. N., Doyle, K. P., & Wu, H.-J. J. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00118 · Cited by 36 · see citing works
The microbiome in mechanically ventilated patients
Yin, Y., Hountras, P., & Wunderink, R. G. (2017) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000352 · Cited by 34 · see citing works
Dysbiosis of human microbiome and infectious diseases
Gupta, A., Singh, V., & Mani, I. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.06.016 · Cited by 36 · see citing works
Zhao, J., Li, L., Chen, C.-Y., Zhang, G., Cui, W., & Tian, B. (2020) · ERJ Open Research · doi:10.1183/23120541.00302-2020 · Cited by 34 · see citing works
Samuelson, D. R., Charles, T. P., de la Rúa, N. M., Taylor, C. M., Blanchard, E., Luo, M., Shellito, J. E., & Welsh, D. A. (2016) · Experimental Lung Research · doi:10.1080/01902148.2016.1258442 · Cited by 32 · see citing works
Feng, J., Dai, W., Zhang, C., Chen, H., Chen, Z., Chen, Y., Pan, Q., & Zhou, Y. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02958-9 · Cited by 31 · see citing works
Petakh, P., Kamyshna, I. I., Nykyforuk, A., Yao, R., Imbery, J. F., Oksenych, V., Korda, M. M., & Kamyshnyi, O. (2022) · Viruses · doi:10.3390/v14030477 · Cited by 32 · see citing works
Xu, L., Yang, C. S., Liu, Y., & Zhang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.895193 · Cited by 33 · see citing works
The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice
Wilson, N. G., Hernandez-Leyva, A. J., Rosen, A. L., Jaeger, N., McDonough, R. T., Santiago-Borges, J. M., Lint, M. A., Rosen, T. R., Tomera, C. P., Bacharier, L. B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.105991 · Cited by 32 · see citing works
Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis
Gurczynski, S. J., Lipinski, J. H., Strauss, J., Alam, S., Huffnagle, G. B., Ranjan, P., Kennedy, L. H., Moore, B. B., & O’Dwyer, D. N. (2023) · JCI Insight · doi:10.1172/jci.insight.164572 · Cited by 31 · see citing works
The gut–organ axis: Clinical aspects and immune mechanisms
Fukasawa, N., Tsunoda, J., Sunaga, S., Kiyohara, H., Nakamoto, N., Teratani, T., Mikami, Y., & Kanai∥, T. (2025) · Allergology International · doi:10.1016/j.alit.2025.01.004 · Cited by 32 · see citing works
- Authors
- Gauguet, S., D'Ortona, S., Ahnger-Pier, K., Duan, B., Surana, N. K., Lu, R., Cywes-Bentley, C., Gadjeva, M., Shan, Q., Priebe, G. P., & Pier, G. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Division of Infectious Diseases, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
- ORCID
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2015-10
- Volume
- 83
- Issue
- 10
- Pages
- 4003-4014
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC4567647
- OpenAlex
- W1789863752
- Cited by
- 208
- References
- 48
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 18 · 2016: 22 · 2015: 1
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL092515)
- National Eye Institute (R01EY022054)
- National Institute of Allergy and Infectious Diseases (K08AI108690, AI057159, R21AI046706, U54AI057159, R01AI046706, AI 46706)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD047349)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- gut microbiota, segmented filamentous bacteria, Staphylococcus aureus pneumonia, methicillin-resistant Staphylococcus aureus, Th17 response, IL-22, pulmonary host defense, lung inflammation, bacterial translocation, cohousing, neutrophils
- MeSH terms
- Gastrointestinal Microbiome, Interleukin-22, Animals, Female, Humans, Interleukins, Intestines, Lung, Male, Mice, Inbred C57BL, Pneumonia, Staphylococcal, Staphylococcus aureus, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
