The postantibiotic effect of antifungal agents against common pathogenic yeasts
Abstract
A total of ten strains of Candida spp. and Cryptococcus neoformans were examined for the presence of the postantibiotic effect (PAE) after 0.5-2 h exposure to amphotericin B, 5-fluorocytosine, miconazole and ketoconazole. Significant PAEs were observed for amphotericin B and 5-fluorocytosine, but none for the imidazoles. The duration of the PAEs of amphotericin B ranged from 0.5-10.4 h for the Candida spp. and 2.8-10.6 h for the cryptococcos, while 5-fluorocytosine induced PAEs from 0.8-7.4 h and 2.4-5.4 h, respectively. Even though no PAEs were demonstrated for the imidazoles, the growth rate was persistently reduced by continuous exposure to concentrations as low as 1/1000 of the MIC of these agents. These findings may have implications for dosing antifungal agents in systemic yeast infections.
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Amphotericin B exposure results in prolonged growth inhibition (postantifungal effect).
“These models have also shown that growth inhibition after amphotericin B exposure continues for long periods of time.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [134]
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In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model
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CD101: a novel long-acting echinocandin
Zhao, Y., Perez, W. B., Jiménez‐Ortigosa, C., Hough, G., Locke, J. B., Ong, V., Bartizal, K., & Perlin, D. S. (2016) · Cellular Microbiology · doi:10.1111/cmi.12640 · Cited by 81 · see citing works
Clancy, C. J., Huang, H., Cheng, S., Derendorf, H., & Nguyen, M. H. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00291-06 · Cited by 73 · see citing works
Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting
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- Authors
- Turnidge, J. D., Gudmundsson, S., Vogelman, B., & Craig, W. A.
- Affiliations
- Monash Medical Centre (AU)
- University of Iceland (IS)
- University of Wisconsin–Madison (US)
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 1994
- Volume
- 34
- Issue
- 1
- Pages
- 83-92
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2118628629
- Cited by
- 105
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- post-antibiotic effect, antifungal agents, Candida, Cryptococcus neoformans, amphotericin B, 5-fluorocytosine, miconazole, ketoconazole, imidazole antifungals, antifungal dosing, subinhibitory concentrations
- MeSH terms
- Amphotericin B, Candida, Cryptococcus neoformans, Flucytosine, Ketoconazole, Miconazole, Microbial Sensitivity Tests
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