The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae
Abstract
Objectives: To identify a novel plasmid-mediated colistin resistance gene in Klebsiella pneumoniae isolated from chickens in China. Methods: WGS was used to identify a novel colistin resistance gene. The transferability of plasmids carrying mcr-7.1 was investigated by conjugation experiments. The expression of the mcr-7.1 gene was examined using an expression vector. Results: A novel plasmid-mediated colistin resistance gene mcr-7.1, sharing 70% amino acid identity with the mcr-3 gene, was identified in three K. pneumoniae strains isolated from chickens in China. The mcr-7.1 gene was found in an IncI2-type plasmid (pSC20141012) that co-harboured the blaCTX-M-55 gene in one isolate. pSC20141012 can be transferred from K. pneumoniae SC20141012 to Escherichia coli J53Azr, exhibiting a ≥8-fold increase in colistin MIC compared with the recipient E. coli J53Azr. Conclusions: We identified a novel plasmid-mediated colistin resistance gene named mcr-7.1 in K. pneumoniae in China. The prevalence of mcr-7.1 in various species of human and animal origin needs to be investigated immediately.
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Zhuang, M., Achmon, Y., Cao, Y., Liang, X., Chen, L., Wang, H., Siame, B. A., & Leung, K. Y. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117402 · Cited by 422
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Metadata
- Authors
- Yang, Y.-Q., Li, Y.-X., Lei, C.-W., Zhang, A.-Y., & Wang, H.-N.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-04-17
- Volume
- 73
- Issue
- 7
- Pages
- 1791-1795
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2801149479
- Cited by
- 367
- References
- 24
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- closed
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