Harnessing the potential of large language models in medical education: promise and pitfalls
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Objectives: To provide balanced consideration of the opportunities and challenges associated with integrating Large Language Models (LLMs) throughout the medical school continuum. Process: Narrative review of published literature contextualized by current reports of LLM application in medical education. Conclusions: LLMs like OpenAI’s ChatGPT can potentially revolutionize traditional teaching methodologies. LLMs offer several potential advantages to students, including direct access to vast information, facilitation of personalized learning experiences, and enhancement of clinical skills development. For faculty and instructors, LLMs can facilitate innovative approaches to teaching complex medical concepts and fostering student engagement. Notable challenges of LLMs integration include the risk of fostering academic misconduct, inadvertent overreliance on AI, potential dilution of critical thinking skills, concerns regarding the accuracy and reliability of LLM-generated content, and the possible implications on teaching staff.
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The quality and difficulty of GPT-4 generated USMLE questions often fall below expectations.
“Lastly, the quality and difficulty of the questions often do not meet expectations (Artsi et al., 2024; Benítez et al., 2024) (Limit3).”
From MCQG-SRefine: Multiple Choice Question Generation and Evaluation with Iterative Self-Critique, Correction, and Comparison Feedback (2025) · cites this paper as Benítez et al., 2024
The Board exam preparation section says ChatGPT-generated USMLE-style questions were generally lower in complexity and not advanced enough to serve as a stand-alone question bank. That supports the concern about question difficulty and adequacy, but the paper does not identify the question-generating model as GPT-4. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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- Authors
- Benítez, T. M., Xu, Y., Boudreau, J. D., Kow, A. W. C., Bello, F., Van Phuoc, L., Wang, X., Sun, X., Leung, G. K.-K., Lan, Y., Wang, Y., Cheng, D., Tham, Y.-C., Wong, T. Y., & Chung, K. C.
- Affiliations
- University of Michigan (US)
- Tsinghua University (CN)
- McGill University (CA)
- National University of Singapore (SG)
- College of Health Sciences, VinUniversity , Hanoi, 100000, Vietnam
- Beihang University (CN)
- Shanghai Jiao Tong University (CN)
- Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital , Hong Kong, 999077, China
- Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital University of Medical Science , Beijing, 100730, China
- Chinese University of Hong Kong, Shenzhen (CN)
- Singapore National Eye Center (SG)
- Corresponding author
- Tham, Yih-Chung
- Chung, Kevin C
- ORCID
- Venue
- Journal of the American Medical Informatics Association
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-01-24
- Volume
- 31
- Issue
- 3
- Pages
- 776-783
- ISSN
- 1067-5027 (ISSN-L)
- 1527-974X
- PMC
- PMC10873781
- OpenAlex
- W4391225179
- Cited by
- 100
- References
- 51
- Citations by year
- 2026: 25 · 2025: 55 · 2024: 19 · 2013: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Medical Informatics Association (publishedVersion)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- National Key Research and Development Program of China (2022YFC2502802)
- National Natural Science Foundation of China (8238810007)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Information Systems › Artificial Intelligence in Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Innovations in Medical Education
- Keywords
- large language models, ChatGPT, medical education, AI in teaching, personalized learning, clinical skills development, academic misconduct, overreliance on AI, critical thinking, medical curriculum
- MeSH terms
- Clinical Competence, Education, Medical, Humans, Language, Learning, Reproducibility of Results
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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