The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity
Abstract
Brown adipose tissue (BAT) is an energy-expending organ that produces heat. Expansion or activation of BAT prevents obesity and diabetes. Chronic cold exposure enhances thermogenesis in BAT through uncoupling protein 1 (UCP1) activation triggered via a β-adrenergic pathway. Here, we report that the cold-sensing transient receptor potential melastatin 8 (TRPM8) is functionally present in mouse BAT. Challenging brown adipocytes with menthol, a TRPM8 agonist, up-regulates UCP1 expression and requires protein kinase A activation. Upon mimicking long-term cold exposure with chronic dietary menthol application, menthol significantly increased the core temperatures and locomotor activity in wild-type mice; these effects were absent in both TRPM8(-/-) and UCP1(-/-) mice. Dietary obesity and glucose abnormalities were also prevented by menthol treatment. Our results reveal a previously unrecognized role for TRPM8, suggesting that stimulation of this channel mediates BAT thermogenesis, which could constitute a promising way to treat obesity.
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Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
PRDM16 controls a brown fat/skeletal muscle switch
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“PR-domain-containing 16 (PRDM16) (Seale et al., 2008) and BMP7 (Tseng et al., 2008) have been recently identified as molecular switches that determine the formation and function of brown adipocytes.”
BackgroundHigh Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
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Independent effects of obesity and insulin resistance on postprandial thermogenesis in men
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Cited by
Adaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Origin and function of stress-induced IL-6 in murine models
Qing, H., Desrouleaux, R., Israni-Winger, K., Mineur, Y. S., Fogelman, N., Zhang, C., Rashed, S., Palm, N. W., Sinha, R., Picciotto, M. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.054 · Cited by 303
Beyond the Sympathetic Tone: The New Brown Fat Activators
Villarroya, F., & Vidal-Puig, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.020 · Cited by 209
Liu, X., Zhang, Z., Song, Y., Xie, H., & Dong, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1065263 · Cited by 102
Metadata
- Authors
- Ma, S., Yu, H., Zhao, Z., Luo, Z., Chen, J., Ni, Y., Jin, R., Ma, L., Wang, P., Zhu, Z., Li, L., Zhong, J., Liu, D., Nilius, B., & Zhu, Z.
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-11
- Volume
- 4
- Issue
- 2
- Pages
- 88-96
- ISSN
- 1674-2788 (ISSN-L)
- 1759-4685
- OpenAlex
- W2123608334
- Cited by
- 238
- References
- 7
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, S., Yu, H., Zhao, Z., Luo, Z., Chen, J., Ni, Y., Jin, R., Ma, L., Wang, P., Zhu, Z., Li, L., Zhong, J., Liu, D., Nilius, B., & Zhu, Z. (2012). Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. Journal of Molecular Cell Biology. https://doi.org/10.1093/jmcb/mjs001
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