PreprintCited by 830Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Open access
Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.·2013·Genes & Development

Abstract

One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.

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Crossref · 10.1101/gad.211649.112

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  • Brite adipocytes can express UCP1 and participate in the maintenance of body temperature.

    “Brite adipocytes can express UCP1 and, as such, can participate in the maintenance of body temperature 90.”
  • Browning is characterized by the appearance of brite (beige) adipocytes mainly in subcutaneous WAT.

    “This process is characterized by the appearance of brite (from brown‐in‐white) adipocytes, also called beige adipocytes, mainly in subcutaneous WAT.”

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Authors
Wu, J., Cohen, P., & Spiegelman, B. M.
Affiliations
  • Harvard University (US)
  • Brigham and Women's Hospital (US)
Venue
Genes & Development
Published
2013-02-01
Volume
27
Issue
3
Pages
234-250
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2170874580
Cited by
828
References
204
Citations by year
2026: 22 · 2025: 29 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 64 · 2020: 64 · 2019: 72 · 2018: 56 · 2017: 91 · 2016: 73 · 2015: 98 · 2014: 91 · 2013: 46 · 2012: 1
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • Foundation for the National Institutes of Health
  • American Heart Association
  • JPB Foundation
  • National Institutes of Health (DK31405)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031405, DK-31405, K01DK094824, RC4DK090861, DK90861, R37DK031405)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
beige adipocytes, brown adipose tissue, thermogenesis, energy expenditure, adaptive thermogenesis, obesity, diabetes mellitus, metabolic disorders, adipogenesis
MeSH terms
Uncoupling Protein 1, Adaptation, Physiological, Animals, Adipose Tissue, Brown, Humans, Ion Channels, Obesity, Adipocytes, Gene Expression Regulation, Developmental, Thermogenesis, Mitochondrial Proteins

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