The DOI matches its Crossref record; 61 of the 63 references it cites were found in a registry or an index.
A Vegetable/Fruit Concentrate with High Antioxidant Capacity Has No Effect on Biomarkers of Antioxidant Status in Male Smokers
Open accessAbstract
The potential benefits of a high fruit and vegetable intake on the antioxidant status and on relevant biomarkers of oxidative damage to lipids, proteins and DNA and on (functional) markers of oxidative stress were evaluated. A randomized, free living, open placebo-controlled cross-over trial of 3 wk, with a 2-wk washout period between treatments, was performed in a group of 22 male smokers with a relatively low vegetable and fruit intake using a vegetable burger and fruit drink. The vegetable burger and fruit drink increased serum levels of vitamin C, alpha-carotene, beta-carotene, beta-cryptoxanthin and zeaxanthin and plasma total antioxidant capacity. However, no effects were demonstrated on any marker of oxidative damage to lipids (malondialdehyde F(2)-isoprostane) proteins (carbonyls) and DNA (Comet assay) and (functional) markers of oxidative stress (reduced/oxidized glutathione ratio, glutathione-S-transferase alpha, glutathione-S-transferase pi and nuclear transcription factor-kappaB). Apparently, these increased levels of antioxidants in serum were not sufficiently high to show beneficial changes with the selected biomarkers. Alternatively, oxidative stress in male smokers with a relatively low fruit and vegetable intake might have been still too low to demonstrate a beneficial effect of antioxidants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Benefits were seen in healthy subjects and in those with existing metabolic risk factors.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
Experimental — accuracy not yet measuredIn the citing paper
“Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
In the citing paper
“The most significant outcomes of these clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
In the citing paper
“Berries were also shown to increase plasma antioxidant capacity36 and to decrease lipid peroxidation42 in smokers who are at high risk of developing CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
In the citing paper
“Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Hayes, J. D., & Pulford, D. J. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509083491 · Cited by 3,464
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441
Antioxidant and redox regulation of gene transcription
Sen, C. K., & Packer, L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635688 · Cited by 1,972
Tomatoes, Tomato-Based Products, Lycopene, and Cancer: Review of the Epidemiologic Literature
Giovannucci, E. L. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.4.317 · Cited by 1,485
Morrow, J. D., Frei, B. B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W., Oates, J. A., & Roberts, L. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321804 · Cited by 1,340
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.21.1550 · Cited by 1,255
Cancer risk and oxidative DNA damage in man
Loft, S. H., & Poulsen, H. E. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00207507 · Cited by 964
Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940
Baker, M. A., Cerniglia, G. J., & Zaman, A. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90208-q · Cited by 921
Manna, S. K., Mukhopadhyay, A., & Aggarwal, B. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6509 · Cited by 876
Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
Collins, A. R., Duthie, S. J., & Dobson, V. L. (1993) · Carcinogenesis · doi:10.1093/carcin/14.9.1733 · Cited by 822
van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (1999) · Food Chemistry · doi:10.1016/s0308-8146(99)00089-8 · Cited by 778
Hertog, M. G. L., Hollman, P. C. H., & Venema, D. P. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00021a023 · Cited by 711
Protein Carbonyl Measurement by a Sensitive ELISA Method
Buss, H., Chan, T., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00104-4 · Cited by 687
Halliwell, B. B. (1996) · Free Radical Research · doi:10.3109/10715769609145656 · Cited by 576
Protective effect of fruits and vegetables on development of stroke in men.
Gillman, M., Cupples, L., Gagnon, D., Posner, B., Ellison, R., Castelli, W., & Wolf, P. (1995) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.1995.03520380049034 · Cited by 563
Rimm, E. B., Katan, M. B., Ascherio, A., Stampfer, M. J., & Willett, W. C. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-5-199609010-00005 · Cited by 560
Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes.
Duthie, S. J., Ma, A., ROSS, M. A., & Collins, A. R. (1996) · PubMed · Cited by 555
STRYKER, W. S., Kaplan, L. A., Stein, E. A., Stampfer, M. J., Sober, A. J., & Willett, W. C. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114804 · Cited by 520
Vitamin E in Humans: Demand and Delivery
Traber, M. G., & Sies, H. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001541 · Cited by 502
Blackwell, T. S., Blackwell, T., Holden, E. P., Christman, B. W., & Christman, J. W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1630 · Cited by 483
Pool-Zobel, B., Bub, A., Müller, H., Wollowski, I., & Rechkemmer, G. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1847 · Cited by 424
Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables
Yeum, K., Booth, S. L., Sadowski, J., Liu, C., Tang, G., Krinsky, N., & Russell, R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.4.594 · Cited by 357
Lipid peroxidation: A review of causes, consequences, measurement and dietary influences
Benzie, I. F. F. (1996) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637489609012586 · Cited by 344
Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis
Mahmoud, N. N. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.921 · Cited by 316
Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status
Young, J. F., Nielsen, S. E., Haraldsdóttir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandström, B., & Dragsted, L. O. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.87 · Cited by 279
Vitamins E plus C and interacting conutrients required for optimal health
GEY, K. F. (1998) · BioFactors · doi:10.1002/biof.5520070115 · Cited by 247
Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?
Riso, P., Pinder, A. C., Santangelo, A., & Porrini, M. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.4.712 · Cited by 223
Fruits and Vegetables Increase Plasma Carotenoids and Vitamins and Decrease Homocysteine in Humans
Broekmans, W. M. R., Klöpping-Ketelaars, I. A. A., Schuurman, C. R. W. C., Verhagen, H., van den Berg, H., Kok, F. J., & van Poppel, G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.6.1578 · Cited by 218
Transcription factor NF-κB as a potential biomarker for oxidative stress
van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001340 · Cited by 205
Diet, antioxidant status, and smoking habits in French men
Marangon, K., Herbeth, B., Lecomte, E., Paul-Dauphin, A., Grolier, P., Chancerelle, Y., Artur, Y., & Siest, G. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.2.231 · Cited by 201
Moderate Intervention with Carotenoid-Rich Vegetable Products Reduces Lipid Peroxidation in Men
Bub, A., Watzl, B., Delincée, H., Adam, S., Wever, J., Müller, H., Rechkemmer, G., & Abrahamse, L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2200 · Cited by 200
Porrini, M., & Riso, P. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.189 · Cited by 194
van Poppel, G., & van den Berg, H. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04662-4 · Cited by 179
Wattenberg, L. W., & Coccia, J. B. (1991) · Carcinogenesis · doi:10.1093/carcin/12.1.115 · Cited by 175
Reduction of oxidative DNA-damage in humans by Brussels sprouts
Verhagen, H., Poulsen, H. E., Loft, S. H., van Poppel, G., Willems, M. I., & van BLADEREN, P. J. (1995) · Carcinogenesis · doi:10.1093/carcin/16.4.969 · Cited by 173
Böhm, V., & Bitsch, R. (1999) · European Journal of Nutrition · doi:10.1007/s003940050052 · Cited by 163
Effects of smoking and vitamin E on blood antioxidant status
Duthie, G., Arthur, Jr., & James, W. P. T. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.4.1061s · Cited by 162
Speek, A. J., Schrijver, J., & Schreurs, W. H. P. (1985) · Journal of Food Science · doi:10.1111/j.1365-2621.1985.tb13291.x · Cited by 161
Bogaards, J. J. P., Verhagen, H., Willems, M. I., van Poppel, G., & van BLADEREN, P. J. (1994) · Carcinogenesis · doi:10.1093/carcin/15.5.1073 · Cited by 160
GEY, K. F. (1995) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(95)00032-u · Cited by 147
Vitamin C and human health--a review of recent data relevant to human requirements.
Weber, P., Bendich, A., & Schalch, W. (1996) · PubMed · Cited by 146
Fruit and vegetable consumption and cancer mortality in the Caerphilly Study.
Hertog, M. G. L., Bueno-de-Mesquita, H. B., FEHILY, A. M., Sweetnam, P. M., Elwood, P. C., & Kromhout, D. (1996) · PubMed · Cited by 137
Nourooz‐Zadeh, J., Gopaul, N. K., Barrow, S. E., Mallet, A. I., & Änggård, E. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00035-h · Cited by 136
Vitamin C elevates red blood cell glutathione in healthy adults
Johnston, C. S., Meyer, C. G., & SRILAKSHMI, J. C. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.1.103 · Cited by 125
Xia, C., Hu, J., KETTERER, B., & Taylor, J. B. (1996) · Biochemical Journal · doi:10.1042/bj3130155 · Cited by 112
Nijhoff, W. A., MULDER, T. P. J., Verhagen, H., van Poppel, G., & Peters, W. H. M. (1995) · Carcinogenesis · doi:10.1093/carcin/16.4.955 · Cited by 108
Therapeutic potential of glutathione.
Exner, R., Wessner, B., Manhart, N., & Roth, E. A. (2000) · PubMed · Cited by 100
Mechanisms by which vegetable consumption reduces genetic damage in humans.
Pool-Zobel, B. L., Bub, A., Liegibel, U. M., Lishaut, S. T.-V., & Rechkemmer, G. (1998) · PubMed · Cited by 94
Hininger‐Favier, I., Chopra, M., Thurnham, D. I., Laporte, F., Richard, M.-J., Favier, A. E., & Roussel, A. M. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600451 · Cited by 90
Speek, A. J., Schrijver, J., & Schreurs, W. H. P. (1984) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00122a043 · Cited by 84
van Vliet, T., Schaik, F. V., van Schoonhoven, J., & Schrijver, J. (1991) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)88486-7 · Cited by 77
Bioavailability of flavonoids.
Hollman, P. C. H. (1997) · PubMed · Cited by 76
Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue
Bresnick, E., Birt, D. F., Wolterman, K., Wheeler, M., & Markin, R. S. (1990) · Carcinogenesis · doi:10.1093/carcin/11.7.1159 · Cited by 72
Glutathione Blood Levels and Other Oxidant Defense Indices in Men Fed Diets Low in Vitamin C
Henning, S. M., Zhang, J. Z., McKee, R. W., Swendseid, M. E., & Jacob, R. A. (1991) · Journal of Nutrition · doi:10.1093/jn/121.12.1969 · Cited by 58
Ascoli, G. A., Bertucci, C., & Salvadori, P. A. (1998) · Biomedical Chromatography · doi:10.1002/(sici)1099-0801(199809/10)12:5 · Cited by 37
Nuclear factor-κB activation is higher in peripheral blood mononuclear cells of male smokers
van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (2001) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(00)00070-3 · Cited by 18
In situ kinetics: An approach to recommended intake of vitamin C
Levine, M., Rumsey, S. C., Wang, Y., Park, J. M., Kwon, O., & Amano, N. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)81048-8 · Cited by 12
Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7
Research works printed but not linked: 2
- Hulshof, K.F.A.M., Kistenmaker, C., Bouwmans, M. & Löwik, M.R.H. (1998) Energy and nutrient intake of the Dutch population—Dutch Nutrition Surveillance System 1997–1998. TNO report V98.805 (in Dutch), pp. 1–13.
- Van den Berg, 2000, The potential for the improvement of carotenoid levels in food and the likely systemic effects, J. Sci. Food Agric, 80, 880, 10.1002/(SICI)1097-0010(20000515)80:7<880::AID-JSFA646>3.0.CO;2-1 · DOI
Cited by
Sorted by citations
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
“However, a fruit and vegetable concentrate, which should have contained many antioxidants, did not have any effect on markers of oxidation in smokers [213].”
BackgroundComparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods
Floegel, A., Kim, D., Chung, S., Koo, S. I., & Chun, O. K. (2011) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2011.01.008 · Cited by 1,818
Dietary Supplement Use in the United States, 2003–2006
Bailey, R. L., Gahche, J. J., Lentino, C. V., Dwyer, J. T., Engel, J. S., Thomas, P. R., Betz, J. M., Sempos, C. T., & Picciano, M. F. (2010) · Journal of Nutrition · doi:10.3945/jn.110.133025 · Cited by 814
Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711
“Kiwi fruit consumption decreased DNA base oxidation, as measured with the comet assay, among human volunteers, possibly by accelerating DNA repair (89), and Thompson et al (90) reported decreased lipid peroxidation (urinary isoprostanes and malondialdehyde) and lymphocyte 8OHdG concentrations among subjects who consum…”
BackgroundBerries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462
“…(Ocean Spray, UK) Increase in plasma antioxidant capacity, vitamin C and phenols with cranberry juice (P < 0.05); no effects with blueberry juice Van den Berg et al. (2001)36 Three weeks with a twoweek washout period Randomized controlled crossover trial Twenty-two male smokers (mean age, 33 ± 11…”
Influential
Metadata
- Authors
- van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H.
- Affiliations
- Maastricht University (NL)
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 131
- Issue
- 6
- Pages
- 1714-1722
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2099422363
- Cited by
- 144
- References
- 63
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 3 · 2019: 3 · 2018: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 8
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- antioxidant status, oxidative stress, smokers, lipid peroxidation, protein carbonylation, DNA damage, glutathione, glutathione S-transferase, NF-κB, carotenoids, vitamin C, dietary supplementation
- MeSH terms
- Adult, Antioxidants, Blood Pressure, Body Weight, Carotenoids, Cholesterol, DNA Damage, Fruit, Humans, Cholesterol, HDL, Male, Malondialdehyde, Middle Aged, Monocytes, Smoking, Time Factors, Triglycerides, Vegetables, Vitamin A, Vitamin E, Oxidative Stress, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
