The DOI matches its Crossref record; 61 of the 63 references it cites were found in a registry or an index.
A Vegetable/Fruit Concentrate with High Antioxidant Capacity Has No Effect on Biomarkers of Antioxidant Status in Male Smokers
Open accessAbstract
The potential benefits of a high fruit and vegetable intake on the antioxidant status and on relevant biomarkers of oxidative damage to lipids, proteins and DNA and on (functional) markers of oxidative stress were evaluated. A randomized, free living, open placebo-controlled cross-over trial of 3 wk, with a 2-wk washout period between treatments, was performed in a group of 22 male smokers with a relatively low vegetable and fruit intake using a vegetable burger and fruit drink. The vegetable burger and fruit drink increased serum levels of vitamin C, alpha-carotene, beta-carotene, beta-cryptoxanthin and zeaxanthin and plasma total antioxidant capacity. However, no effects were demonstrated on any marker of oxidative damage to lipids (malondialdehyde F(2)-isoprostane) proteins (carbonyls) and DNA (Comet assay) and (functional) markers of oxidative stress (reduced/oxidized glutathione ratio, glutathione-S-transferase alpha, glutathione-S-transferase pi and nuclear transcription factor-kappaB). Apparently, these increased levels of antioxidants in serum were not sufficiently high to show beneficial changes with the selected biomarkers. Alternatively, oxidative stress in male smokers with a relatively low fruit and vegetable intake might have been still too low to demonstrate a beneficial effect of antioxidants.
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“Benefits were seen in healthy subjects and in those with existing metabolic risk factors.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
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“The most significant outcomes of these clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
In the citing paper
“Berries were also shown to increase plasma antioxidant capacity36 and to decrease lipid peroxidation42 in smokers who are at high risk of developing CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
In the citing paper
“Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]
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Sorted by citations
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
“However, a fruit and vegetable concentrate, which should have contained many antioxidants, did not have any effect on markers of oxidation in smokers [213].”
BackgroundComparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods
Floegel, A., Kim, D., Chung, S., Koo, S. I., & Chun, O. K. (2011) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2011.01.008 · Cited by 1,818
Dietary Supplement Use in the United States, 2003–2006
Bailey, R. L., Gahche, J. J., Lentino, C. V., Dwyer, J. T., Engel, J. S., Thomas, P. R., Betz, J. M., Sempos, C. T., & Picciano, M. F. (2010) · Journal of Nutrition · doi:10.3945/jn.110.133025 · Cited by 814
Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711
“Kiwi fruit consumption decreased DNA base oxidation, as measured with the comet assay, among human volunteers, possibly by accelerating DNA repair (89), and Thompson et al (90) reported decreased lipid peroxidation (urinary isoprostanes and malondialdehyde) and lymphocyte 8OHdG concentrations among subjects who consum…”
BackgroundBerries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462
“…(Ocean Spray, UK) Increase in plasma antioxidant capacity, vitamin C and phenols with cranberry juice (P < 0.05); no effects with blueberry juice Van den Berg et al. (2001)36 Three weeks with a twoweek washout period Randomized controlled crossover trial Twenty-two male smokers (mean age, 33 ± 11…”
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Metadata
- Authors
- van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H.
- Affiliations
- Maastricht University (NL)
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 131
- Issue
- 6
- Pages
- 1714-1722
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2099422363
- Cited by
- 144
- References
- 63
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 3 · 2019: 3 · 2018: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 8
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- antioxidant status, oxidative stress, smokers, lipid peroxidation, protein carbonylation, DNA damage, glutathione, glutathione S-transferase, NF-κB, carotenoids, vitamin C, dietary supplementation
- MeSH terms
- Adult, Antioxidants, Blood Pressure, Body Weight, Carotenoids, Cholesterol, DNA Damage, Fruit, Humans, Cholesterol, HDL, Male, Malondialdehyde, Middle Aged, Monocytes, Smoking, Time Factors, Triglycerides, Vegetables, Vitamin A, Vitamin E, Oxidative Stress, Cross-Over Studies
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