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Cited by 542

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Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline

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Niculescu, Mihai D., Zeisel, Steven H.·2002·The Journal of Nutrition
DOI 10.1093/jn/132.8.2333s
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Research works printed but not linked: 45

  1. Oligny, 2001, Human molecular embryogenesis: an overview, Pediatr. Dev. Pathol, 4, 324, 10.1007/s10024001-0033-2 · DOI
  2. Jones, 2001, The role of DNA methylation in mammalian epigenetics, Science (Wash., D.C.), 293, 1068, 10.1126/science.1063852 · DOI · Paper page
  3. Baylin, 1998, Alterations in DNA methylation: a fundamental aspect of neoplasia, Adv. Cancer Res, 72, 141, 10.1016/S0065-230X(08)60702-2 · DOI · Paper page
  4. Hendrich, 1998, Identification and characterization of a family of mammalian methyl-CpG binding proteins, Mol. Cell. Biol, 18, 6538, 10.1128/MCB.18.11.6538 · DOI · Paper page
  5. Malone, 2001, CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing, Proc. Natl. Acad. Sci. USA, 98, 10404, 10.1073/pnas.181206898 · DOI
  6. Alonso-Aperte, 1996, Brain folates and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate, Int. J. Vitam. Nutr. Res, 66, 232
  7. Slattery, 1997, Are dietary factors involved in DNA methylation associated with colon cancer?, Nutr. Cancer, 28, 52, 10.1080/01635589709514553 · DOI
  8. Zhu, 1998, Methyl-deficient diets, methylated ER genes and breast cancer: an hypothesized association, Cancer Causes Control, 9, 615, 10.1023/A:1008819210777 · DOI
  9. Lopatina, 1998, Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets, Carcinogenesis, 19, 1777, 10.1093/carcin/19.10.1777 · DOI
  10. Institute of Medicine, and National Academy of Sciences USA. (1998) Dietary Reference Intakes for Folate, Thiamin, Riboflavin, Niacin, Vitamin B12, Panthothenic Acid, Biotin, and Choline, vol. 1. National Academy Press, Washington, D.C.
  11. Zeisel, 1994, Choline and human nutrition, Annu. Rev. Nutr, 14, 269, 10.1146/annurev.nu.14.070194.001413 · DOI · Paper page
  12. Lu, 2001, Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation, Proc. Natl. Acad. Sci. USA, 98, 5560, 10.1073/pnas.091016398 · DOI · Paper page
  13. Selhub, 1991, Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution, Cancer Res, 51, 16
  14. Varela-Moreiras, 1992, Effect of chronic choline deficiency in rats on liver folate content and distribution, J. Nutr. Biochem, 3, 519, 10.1016/0955-2863(92)90073-R · DOI
  15. Horne, 1989, Effect of dietary methyl group deficiency on folate metabolism in rats, J. Nutr, 119, 618, 10.1093/jn/119.4.618 · doi:10.1093/jn/119.4.618
  16. Barak, 1982, Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats, Drug Nutr. Interact, 1, 275
  17. Barak, 1984, Methotrexate hepatotoxicity, J. Am. Coll. Nutr, 3, 93, 10.1080/07315724.1984.10720041 · doi:10.1080/07315724.1984.10720041
  18. Freeman-Narrod, 1977, Chronic toxicity of methotrexate in rats: partial to complete projection of the liver by choline: brief communication, J. Natl. Cancer Inst, 59, 1013, 10.1093/jnci/59.3.1013 · doi:10.1093/jnci/59.3.1013
  19. Pomfret, 1990, Effects of choline deficiency and methotrexate treatment upon rat liver, J. Nutr. Biochem, 1, 533, 10.1016/0955-2863(90)90039-N · DOI
  20. Svardal, 1988, Effect of methotrexate on homocysteine and other compounds in tissues of rats fed a normal or a defined, choline-deficient diet, Cancer Chemother. Pharmacol, 21, 313, 10.1007/BF00264197 · doi:10.1007/bf00264197
  21. Kim, 1995, Folate deficiency causes secondary depletion of choline and phosphocholine in liver, J. Nutr, 124, 2197, 10.1093/jn/124.11.2197 · DOI · Paper page
  22. Poirier, 1977, The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats, Cancer Res, 37, 744
  23. Barak, 1982, The effect of methotrexate on homocysteine methylating agents in rat liver, Drug Nutr. Interact, 1, 303
  24. Shivapurkar, 1983, Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks, Carcinogenesis, 4, 1051, 10.1093/carcin/4.8.1051 · DOI · Paper page
  25. Zeisel, 1989, Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver, Biochem. J, 259, 725, 10.1042/bj2590725 · DOI
  26. Varela-Moreiras, 1995, Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats, J. Am. Coll. Nutr, 14, 480, 10.1080/07315724.1995.10718539 · DOI
  27. Sunden, 1997, Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene, Arch. Biochem. Biophys, 345, 171, 10.1006/abbi.1997.0246 · DOI · Paper page
  28. Tsujiuchi, 1999, Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient l-amino acid-defined diet in rats, Jpn. J. Cancer Res, 90, 909, 10.1111/j.1349-7006.1999.tb00834.x · DOI
  29. Wainfan, 1989, Rapid appearance of hypomethylated DNA in livers of rats fed cancer promoting, methyl-deficient diets, Cancer Res, 49, 4094
  30. Locker, 1986, DNA methylation and hepatocarcinogenesis in rats fed a choline devoid diet, Carcinogenesis, 7, 1309, 10.1093/carcin/7.8.1309 · DOI
  31. Wilson, 1984, Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet, Biochem. J, 218, 987, 10.1042/bj2180987 · DOI
  32. Bhave, 1988, c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino acid-defined diets, Carcinogenesis, 9, 343, 10.1093/carcin/9.3.343 · DOI
  33. Dizik, 1991, Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet, Carcinogenesis, 12, 1307, 10.1093/carcin/12.7.1307 · DOI
  34. Wainfan, 1992, Methyl groups in carcinogenesis: effects on DNA methylation and gene expression, Cancer Res, 52, 2071s
  35. Counts, 1997, Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors, Mol. Carcinog, 18, 97, 10.1002/(SICI)1098-2744(199702)18:2<97::AID-MC5>3.0.CO;2-N · doi:10.1002/(sici)1098-2744(199702)18:2<97::aid-mc5>3.0.co;2-n
  36. Christman, 1993, Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency, Carcinogenesis, 14, 551, 10.1093/carcin/14.4.551 · DOI · Paper page
  37. Kim, 1997, Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene, Am. J. Clin. Nutr, 65, 46, 10.1093/ajcn/65.1.46 · DOI · Paper page
  38. Fang, 1997, Relationship of plasma folic acid and status of DNA methylation in human gastric cancer, J. Gastroenterol, 32, 171, 10.1007/BF02936363 · DOI
  39. Jacob, 1998, Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women, J. Nutr, 128, 1204, 10.1093/jn/128.7.1204 · DOI · Paper page
  40. Fowler, 1998, Hypomethylation in cervical tissue: is there a correlation with folate status?, Cancer Epidemiol. Biomarkers Prev, 7, 901
  41. Li, 1993, Role of DNA methylation in genomic imprinting, Nature, 366, 362, 10.1038/366362a0 · DOI · Paper page
  42. Albright, 1999, Choline availability alters embryonic development of the hippocampus and septum in the rat, Brain Res. Dev. Brain Res, 113, 13, 10.1016/S0165-3806(98)00183-7 · DOI · Paper page
  43. Albright, 1999, Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum, Brain Res. Dev. Brain Res, 115, 123, 10.1016/S0165-3806(99)00057-7 · DOI
  44. Counts, 1996, Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration, Carcinogensis, 17, 1251, 10.1093/carcin/17.6.1251 · DOI
  45. Moyers, 2001, Fetal malformations and folate metabolism: review of recent evidence, Nutr Rev, 59, 215, 10.1111/j.1753-4887.2001.tb07013.x · DOI

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Metadata

Authors
Niculescu, M. D., & Zeisel, S. H.
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2002-08
Volume
132
Issue
8
Pages
2333S-2335S
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/132.8.2333s
OpenAlex
W2099930946
Cited by
542
References
1
FWCI
4.37
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline. https://app.cochat.ai/papers/10.1093/jn/132.8.2333s
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Niculescu, M. D., & Zeisel, S. H. (2002). Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline. The Journal of Nutrition. https://doi.org/10.1093/jn/132.8.2333s

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