The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Olive Oils High in Phenolic Compounds Modulate Oxidative/Antioxidative Status in Men
Open accessAbstract
The aim of the present study was to evaluate whether olive oils high in phenolic compounds influence the oxidative/antioxidative status in humans. Healthy men (n = 12) participated in a double-blind, randomized, crossover study in which 3 olive oils with low (LPC), moderate (MPC), and high (HPC) phenolic content were given as raw doses (25 mL/d) for 4 consecutive days preceded by 10-d washout periods. Volunteers followed a strict very low-antioxidant diet the 3 d before and during the intervention periods. Short-term consumption of olive oils decreased plasma oxidized LDL (oxLDL), 8-oxo-dG in mitochondrial DNA and urine, malondialdehyde in urine (P < 0.05 for linear trend), and increased HDL cholesterol and glutathione peroxidase activity (P < 0.05 for linear trend), in a dose-dependent manner with the phenolic content of the olive oil administered. At d 4, oxLDL after MPC and HPC, and 8-oxo-dG after HPC administration (25 mL, respectively), were reduced when the men were in the postprandial state (P < 0.05). Phenolic compounds in plasma increased dose dependently during this stage with the phenolic content of the olive oils at 1, 2, 4, and 6 h, respectively (P < 0.01). Their concentrations increased in plasma and urine samples in a dose-dependent manner after short-term consumption of the olive oils (P < 0.01). In conclusion, the olive oil phenolic content modulated the oxidative/antioxidative status of healthy men who consumed a very low-antioxidant diet.
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“Only 4 of the 10 selected studies performed the dietary intervention in a double-blind way [31,33,35,40].”
In the citing paper
“After reviewing the full text of the remaining records, only 10 met the inclusion criteria and were included in the meta-analysis [31,32,33,34,35,36,37,38,39,40].”
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“In addition, randomized controlled trials have reported a dose-dependent increment in high-density lipoprotein (HDL) levels with EVOO [211,212]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [211]
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Metadata
- Authors
- Weinbrenner, T., Fitó, M., Torre, R. D. L., Saez, G. T., Rijken, P., Tormos, C., Coolen, S., Albaladejo, M. F., Abanades, S., Schroder, H., Marrugat, J., & Covas, M.-I.
- Affiliations
- Municipal Institute for Medical Research (ES)
- Universitat Pompeu Fabra (ES)
- Universitat de València (ES)
- Universitat Autònoma de Barcelona (ES)
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 134
- Issue
- 9
- Pages
- 2314-2321
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2097668260
- Cited by
- 272
- References
- 54
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 14 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 13 · 2012: 18
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- olive oil, phenolic compounds, oxidative stress, antioxidant status, oxidized LDL, 8-oxoguanine, malondialdehyde, HDL cholesterol, glutathione peroxidase, urinary biomarkers, dose-dependent effects, healthy men
- MeSH terms
- Olive Oil, 8-Hydroxy-2'-Deoxyguanosine, Adult, Antioxidants, Deoxyguanosine, Diet, DNA, Mitochondrial, Dose-Response Relationship, Drug, Double-Blind Method, Glutathione Peroxidase, Humans, Cholesterol, HDL, Lipoproteins, LDL, Male, Malondialdehyde, Oxidation-Reduction, Phenols, Plant Oils, Time Factors, Cross-Over Studies, Postprandial Period
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