Cited by 272Edible Oils Quality and AnalysisPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Olive Oils High in Phenolic Compounds Modulate Oxidative/Antioxidative Status in Men

Open access

Weinbrenner, Tanja, Fitó, Montserrat, Torre, Rafael de la, Saez, Guillermo T., Rijken, Philip, Tormos, Carmen, Coolen, Stefan, Albaladejo, Magí Farré, Abanades, Sergio, Schroder, Helmut, Marrugat, Jaume, Covas, Maria-Isabel·2004·The Journal of Nutrition

DOI 10.1093/jn/134.9.2314

Open this paper in CoChat — free account

Abstract

The aim of the present study was to evaluate whether olive oils high in phenolic compounds influence the oxidative/antioxidative status in humans. Healthy men (n = 12) participated in a double-blind, randomized, crossover study in which 3 olive oils with low (LPC), moderate (MPC), and high (HPC) phenolic content were given as raw doses (25 mL/d) for 4 consecutive days preceded by 10-d washout periods. Volunteers followed a strict very low-antioxidant diet the 3 d before and during the intervention periods. Short-term consumption of olive oils decreased plasma oxidized LDL (oxLDL), 8-oxo-dG in mitochondrial DNA and urine, malondialdehyde in urine (P < 0.05 for linear trend), and increased HDL cholesterol and glutathione peroxidase activity (P < 0.05 for linear trend), in a dose-dependent manner with the phenolic content of the olive oil administered. At d 4, oxLDL after MPC and HPC, and 8-oxo-dG after HPC administration (25 mL, respectively), were reduced when the men were in the postprandial state (P < 0.05). Phenolic compounds in plasma increased dose dependently during this stage with the phenolic content of the olive oils at 1, 2, 4, and 6 h, respectively (P < 0.01). Their concentrations increased in plasma and urine samples in a dose-dependent manner after short-term consumption of the olive oils (P < 0.01). In conclusion, the olive oil phenolic content modulated the oxidative/antioxidative status of healthy men who consumed a very low-antioxidant diet.

Integrity signals

Registry

Crossref · 10.1093/jn/134.9.2314

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W., Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., et al. (2000) · Circulation · doi:10.1161/01.cir.102.18.2284 · Cited by 1,458
Cancer risk and oxidative DNA damage in man
Loft, S. H., & Poulsen, H. E. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00207507 · Cited by 964
Oxidized LDL and Malondialdehyde-Modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery Disease
Holvoet, P., Vanhaecke, J., Janssens, S., de Werf, F. V., & Collen, D. (1998) · Circulation · doi:10.1161/01.cir.98.15.1487 · Cited by 673
Evidence for an Independent and Cumulative Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Endothelial Dysfunction and Oxidative Stress Generation: Effects of Short- and Long-Term Simvastatin Treatment
Ceriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R., & Motz, E. (2002) · Circulation · doi:10.1161/01.cir.0000027569.76671.a8 · Cited by 655
Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents
Visioli, F., Bellomo, G., Montedoro, G. F., & Galli, C. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05546-9 · Cited by 422
Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension
Redón, J., Oliva, M. R., Tormos, C., Giner, V., Chaves, F. J., Iradi, A., & Sáez, G. T. (2003) · Hypertension · doi:10.1161/01.hyp.0000068370.21009.38 · Cited by 420
Mediterranean Dietary Pattern in a Randomized Trial
de Lorgeril, M., Salen, P., Martin, J., Monjaud, I., Boucher, P., & Mamelle, N. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1181 · Cited by 375

Show all 54 references

Research works printed but not linked: 1

Coolen, S. A., van der Ham, W. & Wiseman, S. A. (2002) Biomarkers. European Research on Functional Effects of Dietary Antioxidant: Benefits and Risks. 25–28 September 2002, Cambridge, UK. Free Radic. Biol. Med. 36: 120 (abs.).

Sorted by citations

Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL cholesterol concentrations (ID 1639), maintenance of normal blood pressure (ID 3781), “anti‐inflammatory properties” (ID 1882), “contributes to the upper respiratory tract health” (ID 3468), “can help to maintain a normal function of gastrointestinal tract” (3779), and “contributes to body defences against external agents” (ID 3467) pursuant to Article 13(1) of Regulation (EC) No 1924/2006
EFSA Panel on Dietetic Products, N. A. A. (. (2011) · EFSA Journal · doi:10.2903/j.efsa.2011.2033 · Cited by 491
Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil
Cicerale, S., Lucas, L., & Keast, R. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.09.006 · Cited by 483
Biological Activities of Phenolic Compounds Present in Virgin Olive Oil
Cicerale, S., Lucas, L., & Keast, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020458 · Cited by 467
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 447
Olive oil and the cardiovascular system
Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 408
Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes
Schröder, H. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.05.006 · Cited by 347
Chemistry and Health of Olive Oil Phenolics
Cicerale, S., Conlan, X. A., Sinclair, A. J., & Keast, R. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701856223 · Cited by 343
The role of virgin olive oil components in the modulation of endothelial function
Perona, J. S., Cabello-Moruno, R., & Ruíz-Gutiérrez, V. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.007 · Cited by 282
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272
“In addition, randomized controlled trials have reported a dose-dependent increment in high-density lipoprotein (HDL) levels with EVOO [211,212], and these, contrary to LDL species, are strongly inversely associated with CVD [213].”
Background
Health effects of olive oil polyphenols: Recent advances and possibilities for the use of health claims
Martín‐Peláez, S., Covas, M. I., Fitó, M., Kušar, A., & Pravst, I. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200421 · Cited by 268
The influence of olive oil on human health: not a question of fat alone
Pérez‐Jiménez, F., Ruano, J., Pérez‐Martínez, P., Lopez‐Segura, F., & López‐Miranda, J. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600273 · Cited by 262
Phenolic Content of Virgin Olive Oil Improves Ischemic Reactive Hyperemia in Hypercholesterolemic Patients
Ruano, J., López‐Miranda, J., Fuentes, F. J., Moreno, J. A., Bellido, C., Pérez‐Martínez, P., Lozano, A., Gómez, P., Jiménez, Y., & Pérez‐Jiménez, F. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.078 · Cited by 234
Extra virgin olive oil: More than a healthy fat
Yubero‐Serrano, E. M., López-Moreno, J., Gómez-Delgado, F., & López‐Miranda, J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0304-x · Cited by 237
Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells
Fabiani, R., Rosignoli, P., Bartolomeo, A. D., Fuccelli, R., Servili, M., Montedoro, G. F., & Morozzi, G. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1411 · Cited by 226
Minor Components of Olive Oil: Evidence to Date of Health Benefits in Humans
Covas, M.-I., Ruíz-Gutiérrez, V., de la Torre, R., Kafatos, A., Lamuela-Raventós, R. M., Osada, J., Owen, R. W., & Visioli, F. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00260.x · Cited by 209
Different radical scavenging tests in virgin olive oil and their relation to the total phenol content
Sánchez, C. S., Troncoso, A. M., García-Parrilla, M. C., Granados, J. J. Q., de la Serrana, H. L. G., & Martínez, M. C. L. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.04.037 · Cited by 202
The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial
Mitjavila, M. T., Fandos, M., Salas‐Salvadó, J., Covas, M., Borrego, S., Estruch, R., Lamuela-Raventós, R. M., Corella, D., Martínez‐González, M. Á., Sánchez, J. M., et al. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.002 · Cited by 203
Nutrigenomics of extra‐virgin olive oil: A review
Piroddi, M., Albini, A., Fabiani, R., Giovannelli, L., Luceri, C., Natella, F., Rosignoli, P., Rossi, T., Taticchi, A., Servili, M., et al. (2016) · BioFactors · doi:10.1002/biof.1318 · Cited by 212
Hydroxytyrosol and Its Potential Therapeutic Effects
Hu, T., He, X., Jiang, J., & Xu, X.-L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405820v · Cited by 192
Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187
One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development
González-Santiago, M., Martín-Bautista, E., Carrero, J. J., Fonollá, J., Baró, L., Bartolomé, M. V., Gil-Loyzaga, P. E., & López‐Huertas, E. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.022 · Cited by 183
New Insights into Controversies on the Antioxidant Potential of the Olive Oil Antioxidant Hydroxytyrosol
Rietjens, S. J., Bast, A., & Haenen, G. R. M. M. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0706934 · Cited by 180
The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds
Parkinson, L., & Cicerale, S. (2016) · Molecules · doi:10.3390/molecules21121734 · Cited by 183
Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats
Hamden, K., Allouche, N., Mohamed Damak, A., & Elfeki, A. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.04.002 · Cited by 175
Virgin olive oil: a key food for cardiovascular risk protection
Covas, M., de la Torre, R., & Fitó, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000136 · Cited by 184
Effects of dietary factors on oxidation of low-density lipoprotein particles
Lapointe, A., Couillard, C., & Lemieux, S. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.01.001 · Cited by 170
Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women
Salvini, S., Sera, F., Caruso, D., Giovannelli, L., Visioli, F., Saieva, C., Masala, G., Ceroti, M., Giovacchini, V., Pitozzi, V., et al. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051674 · Cited by 166
Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation
Sirianni, R., Chimento, A., Luca, A. D., Casaburi, I., Rizza, P., Onofrio, A., Iacopetta, D., Puoci, F., Andò, S., Maggiolini, M., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900111 · Cited by 162
Hydrolyzed Olive Vegetation Water in Mice Has Anti-Inflammatory Activity
Bitler, C. M., Viale, T. M., Damaj, B. B., & Crea, R. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1475 · Cited by 161
MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents
Peluso, I., Yarla, N. S., Ambra, R., Pastore, G., & Perry, G. L. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.002 · Cited by 159
Olive oil and cardiovascular health
Covas, M.-I., Konstantinidou, V., & Fitó, M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181c5e7fd · Cited by 158
The Historical Development and Nutritional Importance of Olive and Olive Oil Constituted an Important Part of the Mediterranean Diet
Uylaşer, V., & Yıldız, G. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.626874 · Cited by 167
Virgin Olive Oil Phenols Inhibit Proliferation of Human Promyelocytic Leukemia Cells (HL60) by Inducing Apoptosis and Differentiation
Fabiani, R., Bartolomeo, A. D., Rosignoli, P., Servili, M., Selvaggini, R., Montedoro, G. F., Saverio, C. D., & Morozzi, G. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.614 · Cited by 150
Dietary antioxidants and beneficial effect on oxidatively damaged DNA
Möller, P., & Loft, S. H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.001 · Cited by 144
Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
Warleta, F., Sánchez‐Quesada, C., Campos, M., Allouche, Y., Beltrán, G., & Gaforio, J. J. (2011) · Nutrients · doi:10.3390/nu3100839 · Cited by 145
Olive oil and oxidative stress
Fitó, M., de la Torre, R., & Covas, M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600308 · Cited by 144
Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies
Fabiani, R. (2016) · Food & Function · doi:10.1039/c6fo00958a · Cited by 148
Nutritional and biological properties of extra virgin olive oil
Frankel, E. N. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103813t · Cited by 143
Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: A review of in vitro studies
Casaburi, I., Puoci, F., Chimento, A., Sirianni, R., Ruggiero, C., Avena, P., & Pezzi, V. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200503 · Cited by 143
Elevated Circulating LDL Phenol Levels in Men Who Consumed Virgin Rather Than Refined Olive Oil Are Associated with Less Oxidation of Plasma LDL ,
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Nurmi, T., Poulsen, H. E., Gaddi, A. V., Kaikkonen, J., Zunft, H.-F., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.112912 · Cited by 132
Antioxidants in Sport Nutrition
Lamprecht, M. (2014) · CRC Press eBooks · doi:10.1201/b17442 · Cited by 134
Phenolic compounds in fruits and beverages consumed as part of the mediterranean diet: their role in prevention of chronic diseases
Aguilera, Y., Martin-Cabrejas, M. A., & de Mejía, E. G. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-015-9443-z · Cited by 137
Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders
Peyrol, J., Riva, C., & Amiot, M. J. (2017) · Nutrients · doi:10.3390/nu9030306 · Cited by 126
Antioxidant Activity of Olive Polyphenols in Humans: a Review
Raederstorff, D. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.3.152 · Cited by 127
Vasculoprotective potential of olive oil components.
Carluccio, M., Massaro, M., Scoditti, E., & de Caterina, R. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600305 · Cited by 113
Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review.
Fitó, M., de la Torre, R., Farré, M., Khymenetz, O., Marrugat, J., & Covas, M. (2007) · PubMed · Cited by 110
Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation
Ahmadi, A., Jamialahmadi, T., & Sahebkar, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106414 · Cited by 119
Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study
Zamora‐Ros, R., Urpí-Sardà, M., Lamuela-Raventós, R. M., Estruch, R., Martínez‐González, M. Á., Bulló, M., Arós, F., Cherubini, A., & Andrés‐Lacueva, C. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.023 · Cited by 108
Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena
Costa, M., Bayındır, Z. S., Losada‐Barreiro, S., Paiva‐Martins, F., Saso, L., & Bravo‐Díaz, C. (2021) · Biomedicines · doi:10.3390/biomedicines9121909 · Cited by 114
Cardiovascular friendly natural products: a promising approach in the management of CVD
Shukla, S. K., Gupta, S., Ojha, S. K., & Sharma, S. B. (2010) · Natural Product Research · doi:10.1080/14786410903417378 · Cited by 102
2: Phenolic Compounds Potential Health Benefits and Toxicity
Street, R. A., Prinsloo, G., & McGaw, L. J. (2017) · CRC Press eBooks · doi:10.1201/9781315151540-3 · Cited by 98
Consumption of extra-virgin olive oil rich in phenolic compounds has beneficial antioxidant effects in healthy human adults
Oliveras‐López, M., Berná, G., Jurado‐Ruiz, E., de la Serrana, H. L.-G., & Martı́n, F. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.013 · Cited by 100
Distribution of Resveratrol Metabolites in Liver, Adipose Tissue, and Skeletal Muscle in Rats Fed Different Doses of This Polyphenol
Andrés‐Lacueva, C., Macarulla, M. T., Rotchés-Ribalta, M., Boto‐Ordóñez, M., Urpí-Sardà, M., Rodríguez, V. M., & Portillo, M. P. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3001108 · Cited by 99
Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis
da Silva, S. R. A., Sepodes, B. M. N., Rocha, J. P., Direito, R., Fernandes, A. M. A., Brites, D. M. T. O., Freitas, M., Fernandes, E. G. R., Bronze, M. R., & Figueira, M. E. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.011 · Cited by 95
Antioxidant Effects of a Hydroxytyrosol‐Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double‐Blinded, Placebo‐Controlled Crossover Trial
Colica, C., Renzo, L. D., Trombetta, D., Smeriglio, A., Bernardini, S., Cioccoloni, G., de Miranda, R. C., Gualtieri, P., Salimei, P. S., & LORENZO, A. D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2473495 · Cited by 93
Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans
Oliveras‐López, M., Muros, J. J., Mir, M. V., Rey, E. F., Martín, F., & de la Serrana, H. L.-G. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.04.002 · Cited by 95
Extra-virgin olive oil for potential prevention of Alzheimer disease
Román, G. C., Jackson, R. E., Reis, J. J., Roman, A., Toledo, J. B., & Toledo, E. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.017 · Cited by 95
Mediterranean food and health: building human evidence.
Visioli, F., Bogani, P., Grande, S., & Galli, C. L. (2005) · PubMed · Cited by 86
Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota
Micheli, L., Bertini, L., Bonato, A., Villanova, N., Caruso, C., Caruso, M., Bernini, R., & Tirone, F. (2023) · Nutrients · doi:10.3390/nu15071767 · Cited by 91
Development of a Phenol-Enriched Olive Oil with Phenolic Compounds from Olive Cake
Suárez, M., Romero, M., & Motilva, M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102203x · Cited by 85
Antimicrobial and Antioxidant Activities of Turkish Extra Virgin Olive Oils
Karaosmanoğlu, H., Soyer, F., Ozen, B. F., & Tokatlı, F. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1012105 · Cited by 84
Network Meta-Analysis of Metabolic Effects of Olive-Oil in Humans Shows the Importance of Olive Oil Consumption With Moderate Polyphenol Levels as Part of the Mediterranean Diet
Tsartsou, E., Proutsos, N. D., Castanas, E., & Kampa, M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00006 · Cited by 87
Phenolic Profile and Antioxidant Activity of Italian Monovarietal Extra Virgin Olive Oils
Negro, C., Aprile, A., Luvisi, A., Nicolì, F., Nutricati, E., Vergine, M., Miceli, A., Blando, F., Sabella, E., & Bellis, L. D. (2019) · Antioxidants · doi:10.3390/antiox8060161 · Cited by 82
Hydroxytyrosol Administration Enhances Atherosclerotic Lesion Development in Apo E Deficient Mice
Acı́n, S., Navarro, M. Á., Arbonés-Mainar, J. M., Guillén, N., Sarría, A. J., Carnicer, R., Surra, J. C., Orman, I., Segovia, J. C., de la Torre, R., et al. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj166 · Cited by 82
Is dopamine behind the health benefits of red wine?
de la Torre, R., Covas, M. I., Pujadas, M. A., Fitó, M., & Farré, M. (2006) · European Journal of Nutrition · doi:10.1007/s00394-006-0596-9 · Cited by 82
A Homocysteine Metabolism–Related Dietary Pattern and the Risk of Coronary Heart Disease in Two Independent German Study Populations
Weikert, C., Hoffmann, K., Dierkes, J., Zyriax, B., Klipstein‐Grobusch, K., Schulze, M. B., Jung, R., Windler, E. E. T., & Boeing, H. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1981 · Cited by 82
Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis
Toto, A., Wild, P. P., Graille, M., Turcu, V., Crézé, C., Hemmendinger, M., Sauvain, J., Bergamaschi, E., Canu, I. G., & Hopf, N. B. (2022) · Toxics · doi:10.3390/toxics10040160 · Cited by 81
Evaluation of antioxidant activities of phenolic compounds from two extra virgin olive oils
Nakbi, A., Issaoui, M., Dabbou, S., Koubaa, N., Echbili, A., Hammami, M., & Attia, N. (2010) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2010.05.003 · Cited by 81
Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease
Rigacci, S. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_1 · Cited by 84
Olive Oil Nutraceuticals in the Prevention and Management of Diabetes: From Molecules to Lifestyle
AlKhatib, A. H., Tsang, C., & Tuomilehto, J. O. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072024 · Cited by 80
The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO• response of isolated rat aorta
Rietjens, S. J., Bast, A., de Vente, J., & Haenen, G. R. M. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00755.2006 · Cited by 78
Nutritional Benefit of Olive Oil: The Biological Effects of Hydroxytyrosol and Its Arylating Quinone Adducts
Cornwell, D. G., & Ma, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8015877 · Cited by 79
Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update
Jiménez‐Sánchez, A., Martínez-Ortega, A. J., Remón-Ruiz, P., Piñar-Gutiérrez, A., Cunill, J. L. P., & García‐Luna, P. P. (2022) · Nutrients · doi:10.3390/nu14071440 · Cited by 79
Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
Loft, S. H., Möller, P., Cooke, M. S., Różalski, R., & Oliński, R. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2004-0 · Cited by 76
Effects of olive oil and its fractions on oxidative stress and the liver's fatty acid composition in 2,4-Dichlorophenoxyacetic acid-treated rats
Nakbi, A., Tayeb, W., Grissa, A. K., Issaoui, M., Dabbou, S., Chargui, I., Ellouz, M., Miled, A., & Hammami, M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-80 · Cited by 76
Presence of virgin olive oil phenolic metabolites in human low density lipoprotein fraction: Determination by high-performance liquid chromatography–electrospray ionization tandem mass spectrometry
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Fitó, M., Covas, M., Muñoz‐Aguayo, D., & López‐Sabater, M. C. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.10.029 · Cited by 76
Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial
Gimeno, E., de la Torre‐Carbot, K., Lamuela-Raventós, R. M., Castellote, A. I., Fitó, M., de la Torre, R., Covas, M., & López‐Sabater, M. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507778698 · Cited by 76
Extra virgin olive oil blunt post-prandial oxidative stress via NOX2 down-regulation
Carnevale, R., Pignatelli, P., Nocella, C., Loffredo, L., Pastori, D., Vicario, T., Petruccioli, A., Bartimoccia, S., & Violi, F. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.954 · Cited by 76
Hydroxytyrosol prevents PM2.5-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model
Wang, N., Ma, Y., Liu, Z., Liu, L., Yang, K., Wei, Y., Liu, Y., Chen, X., Sun, X., & Wen, D. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.07.002 · Cited by 74
Olive Fruit Extracts Supplement Improve Antioxidant Capacity via Altering Colonic Microbiota Composition in Mice
Wang, M., Zhang, S., Zhong, R., Wan, F., Chen, L., Liu, L., Yi, B., & Zhang, H. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.645099 · Cited by 70
Acetylation of hydroxytyrosol enhances its transport across differentiated Caco-2 cell monolayers
Mateos, R., Pereira‐Caro, G., Saha, S., Cert, R., Redondo‐Horcajo, M., Bravo, L., & Kroon, P. A. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.054 · Cited by 70
Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: An exploratory nutrigenomics study
Khymenets, O., Fitó, M., Covas, M.-I., Farré, M., Pujadas, M.-A., Muñoz, D., Konstantinidou, V., & Torre, R. D. L. (2009) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0079 · Cited by 68
Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-E-deficient mice: enhanced macrophage cholesterol efflux
Rosenblat, M., Volkova, N., Coleman, R., Almagor, Y., & Aviram, M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.007 · Cited by 68
Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Biomarkers of Oxidative Stress and Inflammation in Healthy Adults: A Randomized Double-Blind Controlled Trial
Sánchez-Rodríguez, E., Biel-Glesson, S., Fernandez-Navarro, J. R., Calleja, M. Á., Espejo-Calvo, J. A., Extremera, B. G., de la Torre, R., Fitó, M., Covas, M., Vílchez, P., et al. (2019) · Nutrients · doi:10.3390/nu11030561 · Cited by 71
Extra virgin olive oil rich in polyphenols modulates VEGF-induced angiogenic responses by preventing NADPH oxidase activity and expression
Calabriso, N., Massaro, M., Scoditti, E., D’Amore, S., Gnoni, A., Pellegrino, M., Storelli, C., Caterina, R. D., Palasciano, G., & Carluccio, M. A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.026 · Cited by 68
Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition
Scoditti, E., Carpi, S., Massaro, M., Pellegrino, M., Polini, B., Carluccio, M. A., Wabitsch, M., Verri, T., Nieri, P., & Caterina, R. D. (2019) · Nutrients · doi:10.3390/nu11102493 · Cited by 68
Squalene: a multi-task link in the crossroads of cancer and aging
Ronco, Á. L., & Stéfani, E. D. (2013) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v3i12.30 · Cited by 65
Antioxidant Effect of Two Virgin Olive Oils Depends on the Concentration and Composition of Minor Polar Compounds
Franconi, F., Coinu, R., Carta, S., Urgeghe, P. P., Ieri, F., Mulinacci, N., & Romani, A. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf053003+ · Cited by 64
Can the Mediterranean diet prevent prostate cancer?
Itsiopoulos, C., Hodge, A. M., & Kaimakamis, M. A. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800207 · Cited by 64
Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans
Alemán-Jiménez, C., Domínguez‐Perles, R., Medina, S., Prgomet, I., López-González, I., Simonelli‐Muñoz, A. J., Cano, M. C., Auñón, D., Ferreres, F., & Gil‐Izquierdo, Á. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02295-0 · Cited by 65
Extra-virgin olive oil consumption improves the capacity of HDL to mediate cholesterol efflux and increases ABCA1 and ABCG1 expression in human macrophages
Helal, O., Berrougui, H., Loued, S., & Khalil, A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003856 · Cited by 63
Evaluation of potential antigenotoxic, cytotoxic and proapoptotic effects of the olive oil by-product “alperujo”, hydroxytyrosol, tyrosol and verbascoside
Anter, J., Tasset, I., Demyda-Peyrás, S., Ranchal, I., Moreno‐Millán, M., Romero-Jiménez, M., Muntané, J., de Castro, M. D. L., Muñoz-Serrano, A., & Alonso-Moraga, Á. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.07.002 · Cited by 63
Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells
Fabiani, R., Fuccelli, R., Pieravanti, F., Bartolomeo, A. D., & Morozzi, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800376 · Cited by 62
Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects
Frank, T., Netzel, G. A., Kammerer, D. R., Carle, R., Kler, A., Kriesl, E., Bitsch, I., Bitsch, R., & Netzel, M. E. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5615 · Cited by 61
Powerful Protective Role of 3,4-Dihydroxyphenylethanol−Elenolic Acid Dialdehyde against Erythrocyte Oxidative-Induced Hemolysis
Paiva‐Martins, F., Fernandes, J. C., Santos, V. P., Silva, L. M., Borges, F., Rocha, S., Belo, L., & Santos‐Silva, A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9031052 · Cited by 61
Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion
Khymenets, O., Fitó, M., Touriño, S., Muñoz‐Aguayo, D., Pujadas, M., Torres, J. L., Joglar, J., Farré, M., Covas, M.-I., & de la Torre, R. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.032821 · Cited by 61
Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary Modulation
Fernández‐García, J. C., Cardona, F., & Tinahones, F. J. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113116660175 · Cited by 63
Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements
Bender, C., Straßmann, S., & Golz, C. (2023) · Nutrients · doi:10.3390/nu15020325 · Cited by 60
Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels
Camargo, A., Rangel-Zúñiga, O. A., Haro, C., Meza-Miranda, E. R., Peña‐Orihuela, P. J., Meneses, M. E. P. D., Marı́n, C., Yubero‐Serrano, E. M., Pérez‐Martínez, P., Delgado‐Lista, J., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.04.047 · Cited by 62
Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence
Farràs, M., Almanza‐Aguilera, E., Hernáez, Á., Agustí, N., Julve, J., Fitó, M., & Castañer, O. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.011 · Cited by 62

Authors: Weinbrenner, T., Fitó, M., Torre, R. D. L., Saez, G. T., Rijken, P., Tormos, C., Coolen, S., Albaladejo, M. F., Abanades, S., Schroder, H., Marrugat, J., & Covas, M.-I.
Affiliations: Municipal Institute for Medical Research (ES)
Universitat Pompeu Fabra (ES)
Universitat de València (ES)
Universitat Autònoma de Barcelona (ES)
ORCID: Fitó, Montserrat
Torre, Rafael de la
Marrugat, Jaume
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2004-09
Volume: 134
Issue: 9
Pages: 2314-2321
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/134.9.2314
OpenAlex: W2097668260
Cited by: 272
References: 54
Citations by year: 2026: 2 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 14 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 13 · 2012: 18
FWCI: 8.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6730 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: olive oil, phenolic compounds, oxidative stress, antioxidant status, oxidized LDL, 8-oxoguanine, malondialdehyde, HDL cholesterol, glutathione peroxidase, urinary biomarkers, dose-dependent effects, healthy men
MeSH terms: Olive Oil, 8-Hydroxy-2'-Deoxyguanosine, Adult, Antioxidants, Deoxyguanosine, Diet, DNA, Mitochondrial, Dose-Response Relationship, Drug, Double-Blind Method, Glutathione Peroxidase, Humans, Cholesterol, HDL, Lipoproteins, LDL, Male, Malondialdehyde, Oxidation-Reduction, Phenols, Plant Oils, Time Factors, Cross-Over Studies, Postprandial Period

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Olive Oils High in Phenolic Compounds Modulate Oxidative/Antioxidative Status in Men

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks