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Antihypertensive Peptides Derived from Egg Proteins
Open accessAbstract
There have been studies of antihypertensive peptides derived from food proteins, but very few described the production of bioactive peptides from egg proteins. The first 2 antihypertensive peptides isolated in egg were obtained by enzymatic hydrolysis of ovalbumin. They correspond to the sequences Phe-Arg-Ala-Asp-His-Pro-Phe-Leu (ovokinin) and Arg-Ala-Asp-His-Phe-Leu (ovokinin 2-7). Both exhibited endothelium-dependent vasodilatory activity. Ovokinin (2-7) had higher antihypertensive potency than ovokinin in spontaneously hypertensive rats (SHR). Modifications in the sequence of ovokinin (2-7) improved the bioavailability of this peptide. It was also demonstrated that different ovalbumin hydrolysates can inhibit angiotensin I-converting enzyme (ACE). We recently obtained an egg white hydrolysate that inhibited the enzyme in vitro. It was obtained by treating egg white with pepsin and it exhibited antihypertensive activity in SHR. Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats. The egg products mentioned could be used as functional food ingredients with potential therapeutic benefit in the prevention and treatment of hypertension.
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“Among the peptides with amino acid sequences of Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe showed strong ACE inhibitory activities.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel and Aleixandre, 2006
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“Miguel and Aleixandre (2006) also produced peptides by hydrolyzing egg white with pepsin.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel and Aleixandre, 2006
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“Feeding these peptides to spontaneously hypertensive rats reduced blood pressure to the rats.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel and Aleixandre, 2006
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Caffa, I., Proietti, E., Turrini, F., Borgarelli, C., Ferrando, M. R., Formisano, E., Neri, L. D. C. L., Martini, D., Angelino, D., Tagliabue, A., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70285 · Cited by 17
Cho, H. Y., Lee, J., Lee, J. H., Ahn, D. U., & Paik, H. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105487 · Cited by 17
Wang, K., Wang, J., Zhao, P., Lin, S., Liu, B., Liu, J., Jones, G. S., & Huang, H. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.07.020 · Cited by 17
Antioxidative capacity of hydrolysates of hen egg proteins
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Metadata
- Authors
- Miguel, M., & Aleixandre, A.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Aleixandre, Amaya
- ORCID
- Miguel, Marta
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 136
- Issue
- 6
- Pages
- 1457-1460
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1892558259
- Cited by
- 168
- References
- 23
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 3 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 18 · 2014: 8 · 2013: 16 · 2012: 14
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
- Funders
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- antihypertensive peptides, egg proteins, ovalbumin, enzymatic hydrolysis, angiotensin-converting enzyme inhibition, endothelium-dependent vasodilation, egg white hydrolysate, pepsin hydrolysis, bioactive peptides, hypertension, functional food ingredients, spontaneously hypertensive rats
- MeSH terms
- Animals, Antihypertensive Agents, Egg Proteins, Hypertension, Ovalbumin, Peptide Fragments, Rats, Inbred SHR, Rats, Inbred WKY, Rats
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