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Cited by 191Skin Protection and AgingPhytochemicals and Antioxidant Activitiesmelanin and skin pigmentation

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Long-Term Ingestion of High Flavanol Cocoa Provides Photoprotection against UV-Induced Erythema and Improves Skin Condition in Women

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Heinrich, Ulrike, Neukam, Karin, Tronnier, Hagen, Sies, Helmut, Stahl, Wilhelm·2006·The Journal of Nutrition
DOI 10.1093/jn/136.6.1565
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Abstract

Dietary antioxidants contribute to endogenous photoprotection and are important for the maintenance of skin health. In the present study, 2 groups of women consumed either a high flavanol (326 mg/d) or low flavanol (27 mg/d) cocoa powder dissolved in 100 mL water for 12 wk. Epicatechin (61 mg/d) and catechin (20 mg/d) were the major flavanol monomers in the high flavanol drink, whereas the low flavanol drink contained 6.6 mg epicatechin and 1.6 mg catechin as the daily dose. Photoprotection and indicators of skin condition were assayed before and during the intervention. Following exposure of selected skin areas to 1.25 x minimal erythemal dose (MED) of radiation from a solar simulator, UV-induced erythema was significantly decreased in the high flavanol group, by 15 and 25%, after 6 and 12 wk of treatment, respectively, whereas no change occurred in the low flavanol group. The ingestion of high flavanol cocoa led to increases in blood flow of cutaneous and subcutaneous tissues, and to increases in skin density and skin hydration. Skin thickness was elevated from 1.11 +/- 0.11 mm at wk 0 to 1.24 +/- 0.13 mm at wk 12; transepidermal water loss was diminished from 8.7 +/- 3.7 to 6.3 +/- 2.2 g/(h x m2) within the same time frame. Neither of these variables was affected in the low flavanol cocoa group. Evaluation of the skin surface showed a significant decrease of skin roughness and scaling in the high flavanol cocoa group compared with those at wk 12. Dietary flavanols from cocoa contribute to endogenous photoprotection, improve dermal blood circulation, and affect cosmetically relevant skin surface and hydration variables.

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Metadata

Authors
Heinrich, U., Neukam, K., Tronnier, H., Sies, H., & Stahl, W.
Affiliations
  • Witten/Herdecke University (DE)
  • Heinrich Heine University Düsseldorf (DE)
Corresponding author
Stahl, Wilhelm
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2006-06
Volume
136
Issue
6
Pages
1565-1569
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/136.6.1565
OpenAlex
W1928567210
Cited by
191
References
35
Citations by year
2026: 6 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 14 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 14 · 2014: 11 · 2013: 10 · 2012: 9
FWCI
8.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Foundation for Cancer Research
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
cocoa flavanols, epicatechin, catechins, photoprotection, UV-induced erythema, skin hydration, skin thickness, transepidermal water loss, skin roughness, skin blood flow, dietary antioxidants, skin health, women
MeSH terms
Adult, Beverages, Cacao, Catechin, Dose-Response Relationship, Drug, Erythema, Female, Humans, Middle Aged, Radiation Protection, Skin, Ultraviolet Rays, Flavones

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