The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
New developments and novel therapeutic perspectives for vitamin C
Open accessAbstract
Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and recommended dietary intake levels are largely based these requirements. However, to function effectively as an antioxidant (or a pro-oxidant), relatively high levels of this vitamin must be maintained in the body. The instability of vitamin C combined with its relatively poor intestinal absorption and ready excretion from the body reduce physiological availability of this vitamin. This inability to maintain high serum levels of vitamin C may have serious health implications and is particularly relevant in the onset and progression of degenerative disease, such as cancer and cardiovascular disease (CVD), which have a strong contributing oxidative damage factor. In this review, we examine recent studies on the regulation of transport mechanisms for vitamin C, related clinical ramifications, and potential implications in high-dose vitamin C therapy. We also evaluate recent clinical and scientific evidence on the effects of this vitamin on cancer and CVD, with focus on the key mechanisms of action that may contribute to the therapeutic potential of this vitamin in these diseases. Several animal models that could be utilized to address unresolved questions regarding the feasibility of vitamin C therapy are also discussed.
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“Due to the inability of the human body to produce endogenous vitamin C, supplementation of the diet can be used to maintain adequate amounts of the nutrient [8].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [8]
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“Due to the inability of the human body to produce endogenous vitamin C, supplementation of the diet can be used to maintain adequate amounts of the nutrient [8].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [8]
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Metadata
- Authors
- Li, Y., & Schellhorn, H. E.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Schellhorn, Herb E.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 137
- Issue
- 10
- Pages
- 2171-2184
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2147164761
- Cited by
- 508
- References
- 218
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 40 · 2023: 22 · 2022: 42 · 2021: 37 · 2020: 35 · 2019: 34 · 2018: 27 · 2017: 25 · 2016: 24 · 2015: 25 · 2014: 20 · 2013: 23 · 2012: 31
- FWCI
- 20.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C, vitamin C transport, antioxidants, pro-oxidants, vitamin C bioavailability, intestinal absorption, oxidative damage, cancer, cardiovascular disease, degenerative diseases, animal models
- MeSH terms
- Ascorbic Acid, Biological Transport, Cardiovascular Diseases, Humans, Neoplasms
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