Cited by 508Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

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New developments and novel therapeutic perspectives for vitamin C

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Li, Yi, Schellhorn, Herb E.·2007·The Journal of Nutrition

DOI 10.1093/jn/137.10.2171

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Abstract

Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and recommended dietary intake levels are largely based these requirements. However, to function effectively as an antioxidant (or a pro-oxidant), relatively high levels of this vitamin must be maintained in the body. The instability of vitamin C combined with its relatively poor intestinal absorption and ready excretion from the body reduce physiological availability of this vitamin. This inability to maintain high serum levels of vitamin C may have serious health implications and is particularly relevant in the onset and progression of degenerative disease, such as cancer and cardiovascular disease (CVD), which have a strong contributing oxidative damage factor. In this review, we examine recent studies on the regulation of transport mechanisms for vitamin C, related clinical ramifications, and potential implications in high-dose vitamin C therapy. We also evaluate recent clinical and scientific evidence on the effects of this vitamin on cancer and CVD, with focus on the key mechanisms of action that may contribute to the therapeutic potential of this vitamin in these diseases. Several animal models that could be utilized to address unresolved questions regarding the feasibility of vitamin C therapy are also discussed.

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“Proline hydroxylation targets HIF-1a for ubiquitinmediated degradation (214,215) and thus decreases HIF-1a levels in the cells.”
Background
Cancer Metastasis: Building a Framework
Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,651
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417 · cited 1×
“The antioxidant property of ascorbic acid is attributed to its ability to reduce potentially damaging ROS, forming, instead, resonance-stabilized and relatively stable ascorbate free radicals (163).”
Background
Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Vegetables, Fruit, and Cancer Prevention
STEINMETZ, K. A., & POTTER, J. D. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00273-8 · Cited by 2,118
Oxygen sensing by HIF hydroxylases
Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Halliwell, B., & Gutteridge, J. M. C. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90305-x · Cited by 2,038
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · cited 1×
“The effects of oxidative stress on the cardiovascular system are multifold and include: 1) ROS-induced apoptosis of endothelial cells (62,63); 2) induction of inflammation by oxidative modification of the expression of proinflammatory genes (64) and cell adhesion (65); 3) reduction of intracellular bioavailability of…”
Background
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
Caterina, R. D., Libby, P., Peng, H., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Shin, W. S., & Liao, J. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118074 · Cited by 1,781
Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population
Blot, W. J., Li, J., Taylor, P. R., Guo, W., Dawsey, S. M., Wang, G.-Q., Yang, C. S., Zheng, S., Gail, M. H., Li, G.-Y., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.18.1483 · Cited by 1,758
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484
Atherosclerosis is an inflammatory disease
Ross, R. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70266-8 · Cited by 1,458
The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease
Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325
Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., Orazem, J., Magorien, R. D., O'Shaughnessy, C., & Ganz, P. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042000 · Cited by 1,325
Oxidative stress and gene regulation
Allen, R. G., & Tresini, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00242-7 · Cited by 1,321
Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.
Quinn, M. T., Parthasarathy, S., Fong, L. G., & Steinberg, D. I. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2995 · Cited by 1,138
Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function
Burton, G. W., & Ingold, K. U. (1986) · Accounts of Chemical Research · doi:10.1021/ar00127a001 · Cited by 1,126
Untitled work
Balady (2007) · doi:10.1161/circulationaha.106.180945 · Cited by 1,118
Reactive Oxygen Species in the Vasculature
Taniyama, Y., & Griendling, K. K. (2003) · Hypertension · doi:10.1161/01.hyp.0000100443.09293.4f · Cited by 1,088
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075
Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells
Marui, N., Offermann, M. K., Swerlick, R., Kunsch, C., Rosen, C. A., Ahmad, M., Alexander, R. W., & Medford, R. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116778 · Cited by 1,072
Vitamin C pharmacokinetics: Implications for oral and intravenous use
Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992
Ascorbic acid: much more than just an antioxidant
Arrigoni, O., & Tullio, M. C. D. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(01)00235-5 · Cited by 988
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans
Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940
Fruit and vegetable intake and risk of cardiovascular disease: The women’s health study
Liu, S., Manson, J. E., Lee, I.-M., Cole, S. R., Hennekens, C. H., Willett, W. C., & Buring, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.922 · Cited by 917
Does vitamin C act as a pro‐oxidant under physiological conditions?
Carr, A. C., & Frei, B. B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9.1007 · Cited by 891
A family of mammalian Na+-dependent L-ascorbic acid transporters
Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U. V., Chen, X.-Z., Wang, Y., Brubaker, R. F., & Hediger, M. A. (1999) · Nature · doi:10.1038/19986 · Cited by 882
The Role of Hypoxia-Induced Factors in Tumor Progression
Vaupel, P. W. (2004) · The Oncologist · doi:10.1634/theoncologist.9-90005-10 · Cited by 851
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
Fraga, C., Motchnik, P., Shigenaga, M., Helbock, H., Jacob, R., & Ames, B. (1991) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.88.24.11003 · Cited by 809
Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein
Bowry, V. W., & Stocker, R. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00067a019 · Cited by 716
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
Cameron, E., & Pauling, L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3685 · Cited by 710
The macrophage foam cell as a target for therapeutic intervention
Li, A. C., & Glass, C. K. (2002) · Nature Medicine · doi:10.1038/nm1102-1235 · Cited by 700
High-Dose Vitamin C versus Placebo in the Treatment of Patients with Advanced Cancer Who Have Had No Prior Chemotherapy: A Randomized Double-Blind Comparison
Moertel, C. G., Fleming, T. R., Creagan, E. T., Rubin, J., O'Connell, M. J., & Ames, M. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120301 · Cited by 637
Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study
Khaw, K., Bingham, S. A., Welch, A. A., Luben, R., Wareham, N. J., Oakes, S., & Day, N. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04128-3 · Cited by 576
Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.
Khan, B. V., Harrison, D. G., Olbrych, M. T., Alexander, R. W., & Medford, R. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9114 · Cited by 538
A review of the epidemiological evidence for the ‘antioxidant hypothesis’
Stanner, S., Hughes, J., Kelly, C., & Buttriss, J. (2004) · Public Health Nutrition · doi:10.1079/phn2003543 · Cited by 537
NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
Mohazzab, K. M., Kaminski, P. M., & Wolin, M. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.6.h2568 · Cited by 536
Inflammation and Atherosclerosis
Stoll, G., & Bendszus, M. (2006) · Stroke · doi:10.1161/01.str.0000226901.34927.10 · Cited by 506
Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man.
Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N., & Yagi, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36884-9 · Cited by 505
A new recommended dietary allowance of vitamin C for healthy young women
Levine, M., Wang, Y., Padayatty, S. J., & Morrow, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171318198 · Cited by 496
Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid
Rumsey, S. C., Kwon, O., Xu, G. W., Burant, C., Simpson, I. A., & Levine, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18982 · Cited by 481
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
Cameron, E., & Pauling, L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4538 · Cited by 476
Nitric oxide and atherosclerosis: An update
Claudio Napoli, A., de Nigris, F., Williams‐Ignarro, S., Pignalosa, O., Sica, V., & Ignarro, L. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.011 · Cited by 471
Demographic variations in the rising incidence of esophageal adenocarcinoma in white males
Bollschweiler, E., Wolfgarten, E., Gutschow, C. A., & H�lscher, A. H. (2001) · Cancer · doi:10.1002/1097-0142(20010801)92:3 · Cited by 452
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin
Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner‐Felmayer, G., & Werner, E. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004392200 · Cited by 427
Dietary antioxidants in preventing atherogenesis
Kaliora, A. C., Dedoussis, G. V., & Schmidt, H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.11.001 · Cited by 417
Antioxidant Effects of Vitamins C and E Are Associated With Altered Activation of Vascular NADPH Oxidase and Superoxide Dismutase in Stroke-Prone SHR
Chen, X., Touyz, R. M., Park, J. B., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/hy09t1.094005 · Cited by 410
Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations
Jackson, T. S., Xu, A., Vita, J. A., & Keaney, J. F. (1998) · Circulation Research · doi:10.1161/01.res.83.9.916 · Cited by 400 · cited 1×
“As a free radical scavenger, ascorbic acid, at high concentrations, reacts directly with superoxide, decreasing its availability and inhibiting superoxide-mediated NO inactivation (141).”
Background
Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression
Salonen, R. M., Nyyssönen, K., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Rissanen, T. H., Tuomainen, T., Valkonen, V.-P., Ristonmaa, U., Lakka, H., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050626.25057.51 · Cited by 379
REGULATION OF VITAMIN C TRANSPORT
Wilson, J. X. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092647 · Cited by 376
Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes
Noroozi, M., Angerson, W., & Lean, M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.6.1210 · Cited by 375
Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases
Dimmeler, S., Haendeler, J., Galle, J., & Zeiher, A. M. (1997) · Circulation · doi:10.1161/01.cir.95.7.1760 · Cited by 371
Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival
Sotiriou, S., Gispert, S., Cheng, J., Wang, Y., Chen, A., Hoogstraten-Miller, S., Miller, G. F., Kwon, O., Levine, M., Guttentag, S. H., et al. (2002) · Nature Medicine · doi:10.1038/0502-514 · Cited by 367
Ascorbic Acid Enhances Endothelial Nitric-oxide Synthase Activity by Increasing Intracellular Tetrahydrobiopterin
Huang, A., Vita, J. A., Venema, R. C., & Keaney, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002248200 · Cited by 365
Untitled work
(2003) · PubMed · Cited by 350
Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein.
Ingold, K. U., Bowry, V. W., Stocker, R., & Walling, C. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.45 · Cited by 345
The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer
Cameron, E., & Campbell, A. (1974) · Chemico-Biological Interactions · doi:10.1016/0009-2797(74)90019-2 · Cited by 344
Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.
Agus, D. B., Gambhir, S. S., Pardridge, W. M., Spielholz, C., Baselga, J. M., Vera, J. C., & Golde, D. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119832 · Cited by 330
Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.
Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., & Kikkawa, R. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2437 · Cited by 329
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis
Salonen, J. T., Nyyssönen, K., Salonen, R., Lakka, H. ‐., Kaikkonen, J., Porkkala‐Sarataho, E., Voutilainen, S., Lakka, T. A., Rissanen, T., Leskinen, L., et al. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00752.x · Cited by 327
Vitamin C Inhibits NF-κB Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase
Bowie, A., & O'Neill, L. A. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.12.7180 · Cited by 310
Upregulation of Superoxide Dismutase and Nitric Oxide Synthase Mediates the Apoptosis-Suppressive Effects of Shear Stress on Endothelial Cells
Dimmeler, S., Hermann, C., Galle, J., & Zeiher, A. M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.656 · Cited by 305
Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E)
Carr, A. C., Zhu, B., & Frei, B. B. (2000) · Circulation Research · doi:10.1161/01.res.87.5.349 · Cited by 305
Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric Oxide Synthase Activity
d’Uscio, L. V., Milstien, S., Richardson, D. M., Smith, L., & Katušić, Z. S. (2003) · Circulation Research · doi:10.1161/01.res.0000049166.33035.62 · Cited by 296
Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial
Fang, J. C.-T., Kinlay, S., Beltrame, J. F., Hikiti, H., Wainstein, M. V., Behrendt, D., Suh, J. H., Frei, B. B., Mudge, G. H., Selwyn, A. P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08154-0 · Cited by 291
Vitamin C Suppresses TNFα-Induced NFκB Activation by Inhibiting IκBα Phosphorylation
Cárcamo, J. M., Pedraza, A. M., Bórquez-Ojeda, O., & Golde, D. W. (2002) · Biochemistry · doi:10.1021/bi0263210 · Cited by 280
Ascorbic acid and carnitine biosynthesis
Rebouche, C. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1147s · Cited by 276
Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin c in the presence of transition metal ions
Retsky, K. L., Freeman, M. W., & Frei, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54075-8 · Cited by 271
Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN
Pianetti, S., Arsura, M., Romieu, R., Coffey, R. J., & Sonenshein, G. E. (2001) · Oncogene · doi:10.1038/sj.onc.1204257 · Cited by 265
Oxidized Low Density Lipoprotein Induces Apoptosis in Cultured Human Umbilical Vein Endothelial Cells by Common and Unique Mechanisms
Harada‐Shiba, M., Kinoshita, M., KAMIDO, H., & Shimokado, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9681 · Cited by 261
Aortic wall damage in mice unable to synthesize ascorbic acid
Maeda, N., Hagihara, H., Nakata, Y., Hiller, S., Wilder, J., & Reddick, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.841 · Cited by 260
How does ascorbic acid prevent endothelial dysfunction?
May, J. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00269-0 · Cited by 260
The antioxidant hypothesis of cardiovascular disease: epidemiology and mechanisms
GEY, K. F. (1990) · Biochemical Society Transactions · doi:10.1042/bst0181041 · Cited by 258
Intravenously administered vitamin C as cancer therapy: three cases
Padayatty, S. J. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.050346 · Cited by 257
Vitamin C transport systems of mammalian cells
Liang, W.-J., Johnson, D., & Jarvis, S. M. (2001) · Molecular Membrane Biology · doi:10.1080/09687680110033774 · Cited by 255
Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial
Engler, M. M., Engler, M. B., Malloy, M. J., Chiu, E. Y., Schloetter, M. C., Paul, S. M., Stuehlinger, M., Lin, K. Y., Cooke, J. P., Morrow, J. D., et al. (2003) · Circulation · doi:10.1161/01.cir.0000086345.09861.a0 · Cited by 253
Evolution of dietary antioxidants
Benzie, I. F. F. (2003) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00368-9 · Cited by 247
Coronary Heart Disease in Smokers: Vitamin C Restores Coronary Microcirculatory Function
Kaufmann, P. A., Gnecchi-Ruscone, T., di Terlizzi, M., Schäfers, K. P., Lüscher, T. F., & Camici, P. G. (2000) · Circulation · doi:10.1161/01.cir.102.11.1233 · Cited by 246
Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
Hiraga, T., Kizaka-Kondoh, S., Hirota, K., Hiraoka, M., & Yoneda, T. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2355 · Cited by 242
NF‐κB activation in development and progression of cancer
Inoue, J., Gohda, J., Akiyama, T., & Semba, K. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00389.x · Cited by 235
Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come?
Halliwell, B. B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1082 · Cited by 235
The In Vitro Cytotoxicity of Ascorbate Depends on the Culture Medium Used to Perform the Assay and Involves Hydrogen Peroxide
Clement, M., Ramalingam, J. K., Long, L. H., & Halliwell, B. B. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100687 · Cited by 231
Supplementation With Vitamins C and E Improves Arterial Stiffness and Endothelial Function in Essential Hypertensive Patients
Plantinga, Y., Ghiadoni, L., Magagna, A., Giannarelli, C., Franzoni, F., Taddei, S., & Salvetti, A. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.09.021 · Cited by 231
Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke
Huang, J., Agus, D. B., Winfree, C. J., Kiss, S., Mack, W. J., McTaggart, R. A., Choudhri, T. F., Kim, L. J., Mocco, J., Pinsky, D. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171325998 · Cited by 225
Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage
Thompson, H. J., Heimendinger, J., Haegele, A. D., SEDLACEK, S. M., Gillette, C. D., O'neill, C., Wolfe, P., & Conry, C. M. (1999) · Carcinogenesis · doi:10.1093/carcin/20.12.2261 · Cited by 222
Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review
Asplund, K. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00973.x · Cited by 220
Routine Vitamin Supplementation To Prevent Cardiovascular Disease: A Summary of the Evidence for the U.S. Preventive Services Task Force
Morris, C. D., & Carson, S. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-1-200307010-00014 · Cited by 212
Supplemention With Tetrahydrobiopterin Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats
Hong, H.-J., Hsiao, G., Cheng, T.-H., & Yen, M.-H. (2001) · Hypertension · doi:10.1161/hy1101.095331 · Cited by 203
Dehydroascorbic Acid Transport by GLUT4 in XenopusOocytes and Isolated Rat Adipocytes
Rumsey, S. C., Daruwala, R., Al‐Hasani, H., Zarnowski, M. J., Simpson, I. A., & Levine, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000988200 · Cited by 202
Vitamin C status and mortality in US adults
Loria, C. M., Klag, M. J., Caulfield, L. E., & Whelton, P. K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.1.139 · Cited by 188
Which Plasma Antioxidants Are Most Related to Fruit and Vegetable Consumption?
Block, G., Norkus, E. P., Hudes, M. L., Mandel, S., & Helzlsouer, K. J. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.12.1113 · Cited by 186
Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation
Bruno, R. S., Leonard, S. W., Atkinson, J., Montine, T. J., Ramakrishnan, R., Bray, T. Μ., & Traber, M. G. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.051 · Cited by 185
Reversal of Endothelial Nitric Oxide Synthase Uncoupling and Up-Regulation of Endothelial Nitric Oxide Synthase Expression Lowers Blood Pressure in Hypertensive Rats
Li, H., Witte, K. K., August, M., Brausch, I., Gödtel‐Armbrust, U., Habermeier, A., Closs, E. I., Oelze, M., Münzel, T. F., & Förstermann, U. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.01.071 · Cited by 181
Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors
Dimmeler, S., & Zeiher, A. M. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00105-1 · Cited by 178
Vitamin C Prevents DNA Mutation Induced by Oxidative Stress
Lutsenko, E. A., Cárcamo, J. M., & Golde, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201151200 · Cited by 176
Macrophage scavenger receptors and foam cell formation
de Villiers, W. J. S., & Smart, E. J. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.740 · Cited by 173
Resolution of the Facilitated Transport of Dehydroascorbic Acid from Its Intracellular Accumulation as Ascorbic Acid
Vera, J. C., Rivas, C. I., Velásquez, F. V., Zhang, R. H., Concha, I. I., & Golde, D. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23706 · Cited by 169
Sodium-dependent ascorbic acid transporter family SLC23
Takanaga, H., Mackenzie, B., & Hediger, M. A. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1104-1 · Cited by 161
Mutagaenic action of ascorbic acid
STICH, H. F., KARIM, J., Koropatnick, J. D., & Lo, L. W. (1976) · Nature · doi:10.1038/260722a0 · Cited by 157
Changes of Terminal Cancer Patients' Health-related Quality of Life after High Dose Vitamin C Administration
Yeom, C. H., Jung, G. C., & Song, K. J. (2007) · Journal of Korean Medical Science · doi:10.3346/jkms.2007.22.1.7 · Cited by 149
p53 family genes: structural comparison, expression and mutation
Ikawa, S., Nakagawara, A., & Ikawa, Y. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400631 · Cited by 146
Oxidative modification of beta-very low density lipoprotein. Potential role in monocyte recruitment and foam cell formation.
Parthasarathy, S., Quinn, M. T., Schwenke, D. C., Carew, T. E., & Steinberg, D. H. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.3.398 · Cited by 145
Vitamin Supplement Use in a Low-Risk Population of US Male Physicians and Subsequent Cardiovascular Mortality
Muntwyler, J., Hennekens, C. H., Manson, J. E., Buring, J. E., & Gaziano, J. M. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.13.1472 · Cited by 144
Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later
González, M. J., Miranda-Massari, J. R., Mora, E., Guzmán, A., Riordan, N. H., Riordan, H. D., Casciari, J. J., Jackson, J. A., & Román‐Franco, A. A. (2005) · Integrative Cancer Therapies · doi:10.1177/1534735404273861 · Cited by 135
Glucose Modulates Vitamin C Transport in Adult Human Small Intestinal Brush Border Membrane Vesicles
Malo, C., & Wilson, J. X. (2000) · Journal of Nutrition · doi:10.1093/jn/130.1.63 · Cited by 135
Combined Vitamin C and E Supplementation Retards Early Progression of Arteriosclerosis in Heart Transplant Patients
Liu, L., & Meydani, M. (2002) · Nutrition Reviews · doi:10.1301/00296640260385810 · Cited by 134
Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity
Qiu, S., Li, L., Weeber, E. J., & May, J. M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21204 · Cited by 133
What Vitamins Should I Be Taking, Doctor?
Willett, W. C., & Stampfer, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmcp010710 · Cited by 133
Effects of ascorbic acid and a-tocopherol on arsenic-induced oxidative stress
Ramanathan, K., Balakumar, B. S., & Panneerselvam, C. (2002) · Human & Experimental Toxicology · doi:10.1191/0960327102ht307oa · Cited by 132
Both Intracellular and Extracellular Vitamin C Inhibit Atherogenic Modification of LDL by Human Vascular Endothelial Cells
Martin-Marco, A., & Frei, B. B. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1583 · Cited by 130
Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells
Palaniappan, M., Thiruppathi, M., Balasubramanian, K., et al. (2005) · Free Radical Research · doi:10.1080/10715760500308154 · Cited by 126
Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate
Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.023 · Cited by 125
α-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status
Bruno, R. S., Ramakrishnan, R., Montine, T. J., Bray, T. Μ., & Traber, M. G. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.95 · Cited by 124
Oxidative DNA damage induced by visible light in mammalian cells: extent, inhibition by antioxidants and genotoxic effects
Pflaum, M., Kielbassa, C., Garmyn, M., & Epe, B. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00029-9 · Cited by 123
Vitamin C prevents metal ion-dependent initiation and propagation of lipid peroxidation in human low-density lipoprotein
Retsky, K. L., & Frei, B. B. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00089-u · Cited by 123
Vitamin C Protects Human Vascular Smooth Muscle Cells Against Apoptosis Induced by Moderately Oxidized LDL Containing High Levels of Lipid Hydroperoxides
Siow, R. C. M., Richards, J. P., Pedley, K. C., Leake, D. S., & Mann, G. E. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.10.2387 · Cited by 120
Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line
MacDonald, L., THUMSER, A. E. A., & Sharp, P. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2001492 · Cited by 117
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model
Fan, X., Reneker, L. W., Obrenovich, M. E., Strauch, C., Cheng, R., Jarvis, S. M., ORTWERTH, B. J., & Monnier, V. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605101103 · Cited by 113
Effect of Vitamin C on the Availability of Tetrahydrobiopterin in Human Endothelial Cells
Baker, T. A., Milstien, S., & Katusic, Z. S. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200103000-00012 · Cited by 113
Vitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E
Abudu, N., Miller, J. J., Attaelmannan, M., & Levinson, S. S. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.09.018 · Cited by 111
The hypoxic tumor microenvironment and gene expression
Leo, C., Giaccia, A. J., & Denko, N. C. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.007 · Cited by 106
Effects of Vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells
kumar, J. S., Banudevi, S., Sharmila, M., Palaniappan, M., Srinivasan, N., Balasubramanian, K., Aruldhas, M. M., & Arunakaran, J. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.08.001 · Cited by 103
Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver
Barja, G., Lopez‐Torres, M., Pérez‐Campo, R., Rojas, C., Cadenas, S., Prat, J., & Pamplona, R. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90108-2 · Cited by 103
Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein
Carr, A. C., TIJERINA, T., & Frei, B. B. (2000) · Biochemical Journal · doi:10.1042/bj3460491 · Cited by 103
Vitamin C Concentrations in Plasma as a Function of Intake: a Meta-analysis
Brubacher, D., Moser, U., & Jordan, P. (2000) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.70.5.226 · Cited by 102
Ameliorative effect of vitamins (α-tocopherol and ascorbic acid) on PCB (Aroclor 1254) induced oxidative stress in rat epididymal sperm
Krishnamoorthy, G., Venkataraman, P., Arunkumar, A., et al. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.12.004 · Cited by 97
Differential Expression of Facilitative Glucose Transporter (GLUT) Genes in Primary Lung Cancers and Their Liver Metastases
Kurata, T., Oguri, T., Isobe, T., et al. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00702.x · Cited by 96
6-Bromo-6-deoxy-l-ascorbic Acid
Corpe, C. P., Lee, J.-H., Kwon, O., Eck, P., Narayanan, J., Kirk, K. L., & Levine, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412925200 · Cited by 95
Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells
Wu, F. Y., Schuster, D. P., Tyml, K., & Wilson, J. X. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.10.033 · Cited by 93
Vitamin C Transport in Oxidized Form across the Rat Blood–Retinal Barrier
Hosoya, K., Minamizono, A., Katayama, K., et al. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0505 · Cited by 93
Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid
SMITH, A. R. W., Visioli, F., & Hagen, T. M. (2002) · The FASEB Journal · doi:10.1096/fj.01-0825fje · Cited by 92
Vitamin C Augments Chemotherapeutic Response of Cervical Carcinoma HeLa Cells by Stabilizing P53
Reddy, V. G., Khanna, N., & Singh, N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4593 · Cited by 91
Effect of antioxidant vitamin supplementation on DNA damage and repair in human lymphoblastoid cells
Sweetman, S. F., Strain, J., & McKelvey‐Martin, V. J. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514513 · Cited by 88
Vulnerable Atherosclerotic Plaque Morphology in Apolipoprotein E–Deficient Mice Unable to Make Ascorbic Acid
Nakata, Y., & Maeda, N. (2002) · Circulation · doi:10.1161/01.cir.0000012142.69612.25 · Cited by 88
Convergence of Redox-Sensitive and Mitogen-Activated Protein Kinase Signaling Pathways in Tumor Necrosis Factor-α–Mediated Monocyte Chemoattractant Protein-1 Induction in Vascular Smooth Muscle Cells
Keulenaer, G. W. D., Ushio‐Fukai, M., Yin, Q., Chung, A. B., Lyons, P. R., Ishizaka, N., Kalpana, R., Taylor, W. R., Alexander, R. W., & Griendling, K. K. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.385 · Cited by 88
l-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms
Park, S., Han, S., Park, C. H., Hahm, E., Lee, S. J., Park, H. K., Lee, S., Kim, W. S., Jung, C. W., Park, K., et al. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.005 · Cited by 87
Translational control of the ascorbic acid transporter SVCT2 in human platelets
Savini, I., Catani, M. V., Arnone, R., Rossi, A., Frega, G., Principe, D. D., & Avigliano, L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.028 · Cited by 85
High-Intensity Statin Treatment for Coronary Heart Disease
Sacks, F. M. (2004) · JAMA · doi:10.1001/jama.291.9.1132 · Cited by 84
Increased superoxide anion in rostral ventrolateral medulla contributes to hypertension in spontaneously hypertensive rats via interactions with nitric oxide
Tai, M., Ling-lin, W., Wu, K. L. H., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.015 · Cited by 84
The repair of oxidized amino acids by antioxidants
Hony, B. M., & Butler, J. A. V. (1984) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(84)90011-6 · Cited by 83
Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage
Catani, M. V., Rossi, A., Costanzo, A., Sabatini, S., Levrero, M., Melino, G., & Avigliano, L. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560077 · Cited by 80
Genetic Variation in the Sodium-dependent Vitamin C Transporters, SLC23A1, and SLC23A2 and Risk for Preterm Delivery
Erichsen, H. C., Engel, S. A. M., Eck, P. K., Welch, R., Yeager, M., Levine, M., Siega-Riz, A. M., Olshan, A. F., & Chanock, S. J. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj035 · Cited by 79
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes
Michels, A. J., Joisher, N., & Hagen, T. M. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00678-1 · Cited by 77
Inhibition of copper-induced LDL oxidation by vitamin C is associated with decreased copper-binding to LDL and 2-oxo-histidine formation
Retsky, K. L., Chen, K., Zeind, A. J., & Frei, B. B. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00151-8 · Cited by 76
Tomato Consumption Modulates Oxidative DNA Damage in Humans
Rehman, A., Bourne, L., Halliwell, B. B., & Rice-Evans, C. A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1235 · Cited by 76
Endotoxin Increases Oxidative Injury to Proteins in Guinea Pig Liver: Protection by Dietary Vitamin C
Cadenas, S., Rojas, C., & Barja, G. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01391.x · Cited by 75
Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C
Liang, W., Johnson, D. R., Ma, L., & Jarvis, S. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00461.2001 · Cited by 74
Occurrence in humans and guinea pigs of the gene related to their missing enzyme l-gulono-γ-lactone oxidase
Nishikimi, M., Koshizaka, T., Ozawa, T., & Yagi, K. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90093-8 · Cited by 71
THE MECHANISM OF THE EXCRETION OF VITAMIN C BY THE HUMAN KIDNEY 1
Ralli, E. P., FRIEDMAN, G. J., & Rubin, S. H. (1938) · Journal of Clinical Investigation · doi:10.1172/jci101006 · Cited by 69
Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2
Eck, P., Erichsen, H. C., Taylor, J. G., Yeager, M., Hughes, A., Levine, M., & Chanock, S. (2004) · Human Genetics · doi:10.1007/s00439-004-1167-x · Cited by 69
Ascorbic Acid Uptake by a High‐Affinity Sodium‐Dependent Mechanism in Cultured Rat Astrocytes
Wilson, J. X. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07396.x · Cited by 69
Ascorbic acid-independent synthesis of collagen in mice
Parsons, K. K., Maeda, N., Yamauchi, M., Banes, A. J., & Koller, B. H. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00339.2005 · Cited by 69
Decreased Expression of Manganese Superoxide Dismutase in Transformed Cells Is Associated with Increased Cytosine Methylation of the SOD2 Gene
Huang, Y., He, T., & Domann, F. E. (1999) · DNA and Cell Biology · doi:10.1089/104454999315051 · Cited by 69
The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease
Neužil, J., Weber, C., & Kontush, A. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00741-3 · Cited by 68
Depletion of Ascorbic Acid Restricts Angiogenesis and Retards Tumor Growth in a Mouse Model
Telang, S., Clem, A. L., Eaton, J. W., & Chesney, J. A. (2007) · Neoplasia · doi:10.1593/neo.06664 · Cited by 67
Prevention of Oxidative DNA Damage in Rats by Brussels Sprouts
Deng, X.-S., Tuo, J., Poulsen, H. E., et al. (1998) · Free Radical Research · doi:10.3109/10715769809069284 · Cited by 65
Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
Antoniades, C. A., Tentolouris, C. A., Toutouza, M., Marinou, K., Goumas, G., Tsioufis, C. P., TOUTOUZAS, P. K., Stefanadis, C., & Tousoulis, D. (2003) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613400 · Cited by 64
Depression of catalase gene expression after immortalization and transformation of mouse liver cells
Sun, Y., Colburn, N. H., & Oberley, L. W. (1993) · Carcinogenesis · doi:10.1093/carcin/14.8.1505 · Cited by 63
Antiproliferative and Proapoptotic Effect of Ascorbyl Stearate in Human Pancreatic Cancer Cells: Association with Decreased Expression of Insulin-Like Growth Factor 1 Receptor
Naidu, K. A., Karl, R. C., Naidu, K. A., et al. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021779624971 · Cited by 61
Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice
Nespereira, B. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.08.009 · Cited by 61
Modulation of tnf-α-induced icam-1 expression, no and h202 production by alginate, allicin and ascorbic acid in human endothelial cells
Mo, S. J., Son, E.-W., Rhee, D. K., et al. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02976837 · Cited by 61
Vitamin C Protects Human Arterial Smooth Muscle Cells Against Atherogenic Lipoproteins
Siow, R. C. M., Sato, H., Leake, D. S., Pearson, J. D., Bannai, S., & Mann, G. E. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.10.1662 · Cited by 60
Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
Tousoulis, D. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00250-8 · Cited by 60
Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants?
Moss, R. W. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735405285882 · Cited by 59
Kinetics of the reaction by which natural vitamin E is regenerated by vitamin C
Nagaoka, S., Kakiuchi, T., Ohara, K., et al. (2006) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2006.12.001 · Cited by 58
Tyrosine kinase signalling in breast cancer: Tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer
Andrechek, E. R., & Muller, W. J. (2000) · Breast Cancer Research · doi:10.1186/bcr56 · Cited by 57
Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL
Rodríguez, J. A., Nespereira, B., Perez-Ilzarbe, M., Eguinoa, E., & Páramo, J. A. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.006 · Cited by 54
Dietary Ascorbic Acid Depresses Plasma and Low Density Lipoprotein Lipid Peroxidation in Genetically Scorbutic Rats
Kimura, H., Yamada, Y., Morita, Y., et al. (1992) · Journal of Nutrition · doi:10.1093/jn/122.9.1904 · Cited by 54
From Hypertension to Heart Failure: Role of Nitric Oxide–Mediated Endothelial Dysfunction and Emerging Insights from Myocardial Contrast Echocardiography
Lapu-Bula, R., & Ofili, E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.014 · Cited by 50
Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage
Catani, M. V., Costanzo, A., Savini, I., Levrero, M., Laurenzi, V. D., Wang, J. Y. J., Melino, G., & Avigliano, L. (2002) · Biochemical Journal · doi:10.1042/bj20011713 · Cited by 48
L ‐ascorbic acid represses constitutive activation of NF‐κB and COX‐2 expression in human acute myeloid leukemia, HL‐60
Han, S., Kım, K., Hahm, E., Lee, S. J., Surh, Y., Park, H. K., Kim, W. S., Jung, C. W., Lee, M. H., Park, K., et al. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20116 · Cited by 47
Vitamin C protects low-density lipoprotein from homocysteine-mediated oxidation
Alul, R. H., Wood, M., Longo, J., Marcotte, A., Campione, A. L., Moore, M. K., & Lynch, S. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00028-5 · Cited by 47
Nitric oxide, an iceberg in cardiovascular physiology:
Rubio, A. R., & Morales-Segura, M. A. (2004) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.09.011 · Cited by 46
Vitamin C blocks TNF-α-induced NF-kB activation and ICAM-1 expression in human neuroblastoma cells
Son, E.-W., Mo, S. J., Rhee, D. K., & Pyo, S. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975434 · Cited by 46
Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression
Rayment, S. J., Shaw, J., Woollard, K. J., Lunec, J., & Griffiths, H. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01383-4 · Cited by 45
Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage
Catani, M. V., Rossi, A., Costanzo, A., et al. (2001) · Biochemical Journal · doi:10.1042/bj3560077 · Cited by 45
Sodium-ascorbate cotransport controls intracellular ascorbate concentration in primary astrocyte cultures expressing the SVCT2 transporter
Korčok, J., Yan, R., Siushansian, R., Dixon, S. J., & Wilson, J. X. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02829-8 · Cited by 44
Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat
Papparella, I., Ceolotto, G., Berto, L., Cavalli, M., Bova, S., Cargnelli, G., Ruga, E. M., Milanesi, O., Franco, L., & Mazzoni, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.010 · Cited by 43
Hormone-Regulated and Glucose-Sensitive Transport of Dehydroascorbic Acid in Immature Rat Granulosa Cells
Kodaman, P. H., & Behrman, H. R. (1999) · Endocrinology · doi:10.1210/endo.140.8.6938 · Cited by 42
Insulin Stimulates Vitamin C Recycling and Ascorbate Accumulation in Osteoblastic Cells*
Qutob, S. S., Dixon, S. J., & Wilson, J. X. (1998) · Endocrinology · doi:10.1210/endo.139.1.5659 · Cited by 41
Adaptive regulation of ascorbate transport in osteoblastic cells
Dixon, S. J., & Wilson, J. X. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070612 · Cited by 40
Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes
Korčok, J., Dixon, S. J., Lo, T. C. Y., & Wilson, J. X. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.016 · Cited by 40
Human Neutrophils Oxidize Low-Density Lipoprotein by a Hypochlorous Acid- Dependent Mechanism: The Role of Vitamin C
Carr, A. C., & Frei, B. B. (2002) · Biological Chemistry · doi:10.1515/bc.2002.065 · Cited by 38
Effect of ascorbic acid administration in hemodialysis patients on in vitro oxidative stress parameters: influence of serum ferritin levels
Chen, W.-T., Lin, Y., Yu, F.-C., Kao, W., Huang, W.-H., & Yan, H.-C. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00419-0 · Cited by 35
Ascorbic acid improves impaired venous and arterial endothelium-dependent dilation in smokers1
de Sousa, M. G., Yugar‐Toledo, J. C., Rubira, M. C., Ferreira‐Melo, S. E., Plentz, R. D. M., Barbieri, D., Consolim‐Colombo, F. M., Irigoyen, M. C., & Moreno, H. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00069.x · Cited by 34
Dehydroascorbic acid prevents apoptosis induced by oxidized low‐density lipoprotein in human monocyte‐derived macrophages
Asmis, R., & Wintergerst, E. S. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2550147.x · Cited by 33
Hyperglycemia Inhibits the Uptake of Dehydroascorbate in Tubular Epithelial Cell
Chen, L., Jia, R., Qiu, C.-J., & Ding, G. (2005) · American Journal of Nephrology · doi:10.1159/000087853 · Cited by 32
Ascorbic acid enhances 17 β-estradiol-mediated inhibition of oxidized low density lipoprotein formation
Hwang, J., Peterson, H., Hodis, H. N., et al. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00376-7 · Cited by 32

Research works printed but not linked: 1

Dimmeler, 1997, Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the ‘response to injury’ hypothesis, Circulation, 95, 1760, 10.1161/01.CIR.95.7.1760 · DOI

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See all 508

Authors: Li, Y., & Schellhorn, H. E.
Affiliations: McMaster University (CA)
Corresponding author: Schellhorn, Herb E.
ORCID: Li, Yi
Schellhorn, Herb E.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2007-10
Volume: 137
Issue: 10
Pages: 2171-2184
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/137.10.2171
OpenAlex: W2147164761
Cited by: 508
References: 218
Citations by year: 2026: 22 · 2025: 21 · 2024: 40 · 2023: 22 · 2022: 42 · 2021: 37 · 2020: 35 · 2019: 34 · 2018: 27 · 2017: 25 · 2016: 24 · 2015: 25 · 2014: 20 · 2013: 23 · 2012: 31
FWCI: 20.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5610 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: vitamin C, vitamin C transport, antioxidants, pro-oxidants, vitamin C bioavailability, intestinal absorption, oxidative damage, cancer, cardiovascular disease, degenerative diseases, animal models
MeSH terms: Ascorbic Acid, Biological Transport, Cardiovascular Diseases, Humans, Neoplasms

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