Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study
Abstract
Objective To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen.Design Randomized, diet-controlled, cross-over study.Setting The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands.Subjects Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully.Interventions Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects.Results Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P=0.02) and 12.4% (P< or =0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption.Conclusions Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.Sponsorship Dutch Foundation for Alcohol Research (SAR).
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Health benefits of long-term regular exercise are ascribed to the anti-inflammatory response elicited by an acute bout of exercise, partly mediated by muscle-derived IL-6.
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From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [207]
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“(1) Contracting skeletal muscle is a major source of circulating IL-6 in response to acute exercise.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [207]
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The 1st World Congress on the Insulin Resistance Syndrome
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Effects of Ethanol Intoxication and Gender on Blood Coagulation
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- Authors
- Sierksma, A., van der Gaag, M., Kluft, C., & Hendriks, H.
- Affiliations
- Netherlands Organisation for Applied Scientific Research (NL)
- Corresponding author
- Hendriks, HFJ
- ORCID
- Venue
- European Journal of Clinical Nutrition
- Published
- 2002-11-01
- Volume
- 56
- Issue
- 11
- Pages
- 1130-1136
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2076812730
- Cited by
- 231
- References
- 33
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 16
- FWCI
- 10.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- moderate drinking, beer, C-reactive protein, fibrinogen, acute phase proteins, cardiovascular risk, postmenopausal women, middle-aged men, controlled diet
- MeSH terms
- Alcohol Drinking, Beer, C-Reactive Protein, Cardiovascular Diseases, Diet, Female, Fibrinogen, Humans, Cholesterol, HDL, Liver, Male, Middle Aged, Triglycerides, Postmenopause, Cross-Over Studies
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