Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response
Open accessAbstract
Monocytes/macrophages are key orchestrators of inflammation and are involved in the pathogenesis of chronic inflammatory disorders, including atherosclerosis. (n-3) Fatty acids, found in fish oil, have been shown to have protective effects in such disorders. To investigate possible modes of action, we used a monocyte:endothelial cell (EC) coculture model to investigate the pro-inflammatory potential of monocytes. Monocytes were isolated from the blood of donors with peripheral arterial disease (PAD) or control donors, before and after a 12-wk supplementation of their diet with fish oil. The monocytes were cultured with human umbilical vein EC (HUVEC) for 24 h, after which the ability of the HUVEC to recruit flowing neutrophils was tested. Monocytes from either group of donors stimulated the EC to support the adhesion and migration of neutrophils. Fish oil supplementation reduced the potency of monocytes from normal subjects, but not those from patients with PAD, to induce recruitment. Concurrent medication may have acted as a complicating factor. On subgroup analysis, only those free of medication showed a significant effect of fish oil. Responses before or after supplementation were not closely linked to patterns of secretion of cytokines by cultured monocytes, tested in parallel monocultures. These results suggest that fish oil can modulate the ability of monocytes to stimulate EC and that this might contribute to their protective effects against chronic inflammatory disorders. Benefits, however, may depend on existing medical status and on other treatments being received.
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Patients with type 2 diabetes have a higher postprandial inflammatory response than non-diabetics, independent of body weight.
“Patients with type 2 diabetes exhibit a higher postprandial inflammatory response than non-diabetics, irrespective of their body weight (165,166) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [166]
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- Authors
- Luu, N.-T., Madden, J., Calder, P. C., Grimble, R. F., Shearman, C. P., Chan, T., Dastur, N., Howell, W. M., Rainger, G. E., & Nash, G. B.
- Affiliations
- University of Birmingham (GB)
- University of Southampton (GB)
- Corresponding author
- Nash, Gerard B.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 137
- Issue
- 12
- Pages
- 2769-2774
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2109596695
- Cited by
- 41
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Directorate for Biological Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- fish oil supplementation, omega-3 fatty acids, monocytes, neutrophil recruitment, peripheral arterial disease, atherosclerosis, chronic inflammation, anti-inflammatory activity
- MeSH terms
- Cell Adhesion, Cells, Cultured, Fish Oils, Humans, Inflammation, Male, Monocytes, Neutrophils, Phospholipids, Case-Control Studies, Cytokines, Peripheral Vascular Diseases, Dietary Supplements, Avian Proteins, Endothelial Cells
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