Mitigation of Secondary Disease of Allogeneic Mouse Radiation Chimeras by Modification of the Intestinal Microflora
Abstract
SUMMARY-Conventional CBA mice subjected to lethal whole-body irradiation and allogeneic bone-marrow trans-plantation developed delayed secondary disease, which caused 95 % mortality within 100 days. Symptoms of secondary disease as well as mortality were virtually absent in similarly treated mice kept in the germfree state or given a colonization-resistant (CR) flora. Conventionali-zation of these mice as early as 40 days after transplanta-tion did not induce a significant degree of secondary disease except in 1 group of CR mice derived from con-ventional mice by antibiotic treatment. The acute form of secondary disease occurring after transplantation of allo-geneic spleen cells was much less influenced by the gnoto-biotic conditions, which confirmed the concept that the mortality was caused primarily by severe graft-versus-host
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Animal models indicate that commensal bacteria affect GVHD pathophysiology.
“Preclinical models have shown that commensal bacteria influence the pathophysiology of GVHD.10,17–20”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [17]
Early human studies found that broad-spectrum antibiotics before stem cell transplant reduced GVHD rates.
“early studies demonstrating reduced rates of GVHD in patients treated with broad-spectrum antibiotics prior to HSCT”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as van Bekkum et al., 1974
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- Authors
- Bekkum, D. W. V., Roodenburg, J., Heidt, P. J., & Waaij, D. V. D.
- ORCID
- Heidt, P. J.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1974-02
- Volume
- 52
- Issue
- 2
- Pages
- 401-404
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1918787965
- Cited by
- 330
- References
- 0
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 12 · 2023: 10 · 2022: 4 · 2021: 17 · 2020: 20 · 2019: 15 · 2018: 8 · 2017: 19 · 2016: 23 · 2015: 16 · 2014: 14 · 2013: 5 · 2012: 12
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- secondary disease, radiation chimeras, allogeneic bone marrow transplantation, gut microbiota, germ-free mice, gnotobiotic mice, graft-versus-host disease, whole-body irradiation, antibiotic therapy, spleen cell transfer, CBA mice, mortality
- MeSH terms
- Animals, Bacterial Infections, Bone Marrow Cells, Female, Germ-Free Life, Graft vs Host Reaction, Intestines, Male, Mice, Inbred CBA, Radiation Chimera, Spleen, Transplantation, Homologous, Bone Marrow Transplantation, Mice
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