Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

Shono, Yusuke; Docampo, Melissa D.; Peled, Jonathan U.; Perobelli, Suelen M.; Velardi, Enrico; Tsai, Jennifer J.; Slingerland, Ann E.; Smith, Odette M.; Young, Lauren F.; Gupta, Jyotsna; Lieberman, Sophia R.; Jay, Hillary V.; Ahr, Katya F.; Porosnicu Rodriguez, Kori A.; Xu, Ke; Calarfiore, Marco; Poeck, Hendrik; Caballero, Silvia; Devlin, Sean M.; Rapaport, Franck; Dudakov, Jarrod A.; Hanash, Alan M.; Gyurkocza, Boglarka; Murphy, George F.; Gomes, Camilla; Liu, Chen; Moss, Eli L.; Falconer, Shannon B.; Bhatt, Ami S.; Taur, Ying; Pamer, Eric G.; van den Brink, Marcel R. M.; Jenq, Robert R.

doi:10.1126/scitranslmed.aaf2311

Cited by 592Hematopoietic Stem Cell TransplantationNeutropenia and Cancer InfectionsGut microbiota and health

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

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Shono, Yusuke, Docampo, Melissa D., Peled, Jonathan U., Perobelli, Suelen M., Velardi, Enrico, Tsai, Jennifer J., Slingerland, Ann E., Smith, Odette M. +25 more·2016·Science Translational Medicine

DOI 10.1126/scitranslmed.aaf2311PMC PMC4991773

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Abstract

Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated with an increase in graft-versus-host disease in mice and humans.

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Single-center studies have linked post-HCT intestinal microbiota features to relapse, GVHD, infection, organ toxicity, and overall survival.
“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
Certain antibiotics given at particular times correlate with death from transplantation-related causes and from GVHD.
“and exposure to certain antibiotic agents at specific times is associated with transplantation-related mortality and GVHD-related mortality.10,16”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
Animal models indicate that commensal bacteria affect GVHD pathophysiology.
“Preclinical models have shown that commensal bacteria influence the pathophysiology of GVHD.10,17–20”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
Broad-spectrum antibiotics before T cell therapy can deplete gut microbes and reduce ICB efficacy or raise GVHD-related mortality.
“Conversely, depletion of gut microbes by broad-spectrum antibiotics prior to T cell therapy can reduce ICB efficacy9 or increase GVHD-related mortality10.”
From A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy (2023) · cites this paper as [10]
These high-risk antibiotics have broad anti-pseudomonal activity and are known to strongly disrupt the gut microbiome by targeting anaerobic commensals.
“These antibiotics exert a considerable broad-spectrum, anti-pseudomonal activity, and are also known to severely disrupt the gut microbiome by targeting many anaerobic commensals10,26.”
From A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy (2023) · cites this paper as [10]

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The Antimicrobial Peptide Cathelicidin Protects Mice from Escherichia coli O157:H7-Mediated Disease
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Opportunistic infections after blood and marrow transplantation
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Early outcomes after allogeneic stem cell transplantation for leukemia and myelodysplasia without protective isolation: A 10-year experience
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A Small-Molecule c-Rel Inhibitor Reduces Alloactivation of T Cells without Compromising Antitumor Activity
Shono, Y., Tuckett, A. Z., Ouk, S., Liou, H., Altan-Bonnet, G. Y., Tsai, J. J.-Y., Oyler, J. E., Smith, O. M., West, M. L., Singer, N. V., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0585 · Cited by 59 · see citing works
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Infectious Complications in Patients Undergoing Marrow Transplantation: A Prospective Randomized Study of the Additional Effect of Decontamination and Laminar Air Flow Isolation among Patients Receiving Prophylactic Systemic Antibiotics
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Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses
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Bone Marrow Graft-versus-Host Disease: Evaluation of Its Clinical Impact on Disrupted Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation
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The d ‐alanine content of lipoteichoic acid is crucial for Lactobacillus plantarum‐mediated protection from visceral pain perception in a rat colorectal distension model
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Prevention of Peritransplantation Viridans Streptococcal Bacteremia with Early Vancomycin Administration: A Single‐Center Observational Cohort Study
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The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.015 · Cited by 1,392 · see citing works
Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy
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Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation
Peled, J. U., Gomes, A. L. C., Devlin, S. M., Littmann, E. R., Taur, Y., Sung, A. D., Weber, D., Hashimoto, D., Slingerland, A. E., Slingerland, J. B., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1900623 · Cited by 765 · see citing works
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Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer
Derosa, L., Routy, B., Thomas, A. M., Iebba, V., Zalcman, G., Friard, S., Mazieres, J., Audigier-Valette, C., Moro-Sibilot, D., Goldwasser, F., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01655-5 · Cited by 685 · see citing works
Microbiome and cancer
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The gut microbiota influences anticancer immunosurveillance and general health
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Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer
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Antibiotic perturbations to the gut microbiome
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Lactose drives Enterococcus expansion to promote graft-versus-host disease
Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., et al. (2019) · Science · doi:10.1126/science.aax3760 · Cited by 384 · see citing works
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Modulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant
Taur, Y., Coyte, K. Z., Schlüter, J., Robilotti, E. V., Figueroa, C. J., Gjonbalaj, M., Littmann, E. R., Ling, L., Miller, L., Gyaltshen, Y., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap9489 · Cited by 370 · see citing works
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Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
Smith, M., Dai, A., Ghilardi, G., Amelsberg, K. V., Devlin, S. M., Pajarillo, R., Slingerland, J. B., Beghi, S., Herrera, P. S., Giardina, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01702-9 · Cited by 349 · see citing works
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Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation
Peled, J. U., Devlin, S. M., Staffas, A., Lumish, M., Khanin, R., Littmann, E. R., Ling, L., Kosuri, S., Maloy, M., Slingerland, J. B., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.3348 · Cited by 325 · see citing works
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Gut microbiota injury in allogeneic haematopoietic stem cell transplantation
Shono, Y., & van den Brink, M. R. M. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2018.10 · Cited by 312 · see citing works
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Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
MacDonald, K. P. A., Hill, G. R., & Blazar, B. R. (2016) · Blood · doi:10.1182/blood-2016-06-686618 · Cited by 303 · see citing works
Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the “Net State of Immunosuppression”
Roberts, M. B., & Fishman, J. A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1189 · Cited by 283 · see citing works
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota
Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vétizou, M., Kuns, R. D., Robb, R. J., Zhang, P., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.011 · Cited by 258 · see citing works
Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation
Weber, D., Jenq, R. R., Peled, J. U., Taur, Y., Hiergeist, A., Koestler, J., Dettmer, K., Weber, M., Wolff, D., Hahn, J., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2017.02.006 · Cited by 245 · see citing works
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A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy
Stein-Thoeringer, C. K., Saini, N. Y., Zamir, E., Blumenberg, V., Schubert, M.-L., Mor, U., Fante, M. A., Schmidt, S., Hayase, E., Hayase, T., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02234-6 · Cited by 255 · see citing works
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The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor?
Elkrief, A., Derosa, L., Kroemer, G., Zitvogel, L., & Routy, B. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz206 · Cited by 246 · see citing works
Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential
Ioannou, A., Berkhout, M. D., Geerlings, S. Y., & Belzer, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01106-1 · Cited by 245 · see citing works
Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016
Ullmann, A. J., Schmidt‐Hieber, M., Bertz, H., Heinz, W., Kiehl, M. G., Krüger, W., Mousset, S., Neuburger, S., Neumann, S., Penack, O., et al. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2711-1 · Cited by 214 · see citing works
Introduction to host microbiome symbiosis in health and disease
Malard, F., Dore, J. M., Gaugler, B., & Mohty, M. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00365-4 · Cited by 211 · see citing works
The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease
Staffas, A., da Silva, M. B., & van den Brink, M. R. M. (2016) · Blood · doi:10.1182/blood-2016-09-691394 · Cited by 210 · see citing works
Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation
Golob, J. L., Pergam, S. A., Srinivasan, S., Fiedler, T. L., Liu, C., Garcia, K., Mielcarek, M., Ko, D., Aker, S., Marquis, S., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix699 · Cited by 201 · see citing works
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Current Concepts and Advances in Graft-Versus-Host Disease Immunology
Hill, G. R., Betts, B. C., Tkachev, V., Kean, L. S., & Blazar, B. R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102119-073227 · Cited by 198 · see citing works
Acute graft-versus-host disease of the gut: considerations for the gastroenterologist
Naymagon, S., Naymagon, L., Wong, S.-Y., Ko, H. M., Renteria, A. S., Levine, J. E., Colombel, J., & Ferrara, J. L. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.126 · Cited by 187 · see citing works
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 188 · see citing works
Antibiotic-Induced Depletion of Anti-inflammatory Clostridia Is Associated with the Development of Graft-versus-Host Disease in Pediatric Stem Cell Transplantation Patients
Simms-Waldrip, T. R., Sunkersett, G., Coughlin, L. A., Savani, M. R., Arana, C., Kim, J., Kim, M., Zhan, X., Greenberg, D. E., Xie, Y., et al. (2017) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2017.02.004 · Cited by 175 · see citing works
The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD
Markey, K. A., Schlüter, J., Gomes, A. L. C., Littmann, E. R., Pickard, A. J., Taylor, B. P., Giardina, P. A., Weber, D., Dai, A., Docampo, M. D., et al. (2020) · Blood · doi:10.1182/blood.2019003369 · Cited by 171 · see citing works
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Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?
Derosa, L., Routy, B., Desilets, A., Daillère, R., Terrisse, S., Kroemer, G., & Zitvogel, L. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0236 · Cited by 170 · see citing works
Microbial metabolite sensor GPR43 controls severity of experimental GVHD
Fujiwara, H., Docampo, M. D., Riwes, M. M., Peltier, D., Toubai, T., Henig, I. J., Wu, S.-R. J., Kim, S. H., Taylor, A., Brabbs, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06048-w · Cited by 164 · see citing works
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Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients
van Lier, Y. F., Davids, M., Haverkate, N. J. E., de Groot, P. F., Donker, M. L., Meijer, E., Heubel-Moenen, F. C. J. I., Nur, E., Zeerleder, S. S., Nieuwdorp, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8926 · Cited by 165 · see citing works
In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes
Chanderraj, R., Baker, J. M., Kay, S. G., Brown, C. A., Hinkle, K. J., Fergle, D. J., McDonald, R. A., Falkowski, N. R., Metcalf, J. D., Kaye, K. S., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.00910-2022 · Cited by 156 · see citing works
Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
Michonneau, D., Latis, E., Curis, E., Dubouchet, L., Ramamoorthy, S., Ingram, B. O., de Latour, R. P., Robin, M., de Fontbrune, F. S., Chevret, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13498-3 · Cited by 149 · see citing works
The varying effects of antibiotics on gut microbiota
Yang, L., Bajinka, O., Jarju, P. O., Tan, Y., Taal, A. M., & Özdemir, G. (2021) · AMB Express · doi:10.1186/s13568-021-01274-w · Cited by 151 · see citing works
Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease
Zhao, D., Kim, Y., Jeong, S., Greenson, J. K., Chaudhry, M. S., Hoepting, M., Anderson, E. R., van den Brink, M. R. M., Peled, J. U., Gomes, A. L. C., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99261 · Cited by 141 · see citing works
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Role of the microbiota in response to and recovery from cancer therapy
Blake, S. J., Wolf, Y., Boursi, B., & Lynn, D. J. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00951-0 · Cited by 146 · see citing works
Repeated fecal microbiota transplantations attenuate diarrhea and lead to sustained changes in the fecal microbiota in acute, refractory gastrointestinal graft- versus -host-disease
Spindelboeck, W., Schulz, E., Uhl, B., Kashofer, K., Aigelsreiter, A., Zinke-Cerwenka, W., Mulabecirovic, A., Kump, P. K., Halwachs, B., Gorkiewicz, G., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.154351 · Cited by 132 · see citing works
Fecal microbiota transplantation before or after allogeneic hematopoietic transplantation in patients with hematologic malignancies carrying multidrug-resistance bacteria
Battipaglia, G., Malard, F., Rubio, M., Ruggeri, A., Mamez, A., Brissot, É., Giannotti, F., Duléry, R., Joly, A. C., Baylatry, M. T., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.198549 · Cited by 132 · see citing works
Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children
Davidovics, Z. H., Michail, S. K., Nicholson, M. R., Kociolek, L. K., Pai, N., Hansen, R., Schwerd, T., Maspons, A., Shamir, R., Szajewska, H., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002205 · Cited by 127 · see citing works
New and emerging therapies for acute and chronic graft versus host disease
Hill, L. C., Alousi, A. M., Kebriaei, P., Mehta, R. S., Rezvani, K., & Shpall, E. J. (2017) · Therapeutic Advances in Hematology · doi:10.1177/2040620717741860 · Cited by 116 · see citing works
Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation
Ingham, A. C., Kielsen, K., Cilieborg, M. S., Lund, O., Holmes, S., Aarestrup, F. M., Müller, K., & Pamp, S. J. (2019) · Microbiome · doi:10.1186/s40168-019-0745-z · Cited by 115 · see citing works
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease
Hayase, E., Hayase, T., Jamal, M. A., Miyama, T., Chang, C., Ortega, M. R., Ahmed, S., Karmouch, J. L., Sanchez, C. A., Brown, A. N., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.007 · Cited by 115 · see citing works
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Pathogenesis of acute graft‐versus‐host disease: from intestinal microbiota alterations to donor T cell activation
Zeiser, R., Socié, G., & Blazar, B. R. (2016) · British Journal of Haematology · doi:10.1111/bjh.14295 · Cited by 113 · see citing works
The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future
Andermann, T. M., Peled, J. U., Ho, C. M., Reddy, P. R., Riches, M., Storb, R. F., Teshima, T., van den Brink, M. R. M., Alousi, A. M., Balderman, S., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.02.009 · Cited by 112 · see citing works
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Characterization of oral and gut microbiome temporal variability in hospitalized cancer patients
Galloway-Peña, J., Smith, D. P., Sahasrabhojane, P. V., Wadsworth, W. D., Fellman, B. M., Ajami, N. J., Shpall, E. J., Daver, N. G., Guindani, M., Petrosino, J. F., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0409-1 · Cited by 112 · see citing works
Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice
Bajic, D., Niemann, A., Hillmer, A.-K., Mejías‐Luque, R., Bluemel, S., Docampo, M. D., Funk, M. C., Tonin, E., Boutros, M., Schnabl, B., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa065 · Cited by 113 · see citing works
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The gut microbiota and graft-versus-host disease
Fredricks, D. N. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125797 · Cited by 112 · see citing works
Alterations to the Esophageal Microbiome Associated with Progression from Barrett's Esophagus to Esophageal Adenocarcinoma
Snider, E. J., Compres, G., Freedberg, D. E., Khiabanian, H., Nobel, Y. R., Stump, S., Uhlemann, A., Lightdale, C. J., & Abrams, J. A. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0008 · Cited by 108 · see citing works
Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients
Pettigrew, M. M., Gent, J. F., Kong, Y., Halpin, A. L., Pineles, L. L., Harris, A. D., & Johnson, J. K. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy936 · Cited by 106 · see citing works
Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: lack of commensal sparing antibiotics.
Weber, D., Hiergeist, A., Weber, M., Dettmer, K., Wolff, D., Hahn, J., Herr, W., Gessner, A., & Holler, E. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciy711 · Cited by 92 · see citing works
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD
Sofi, M. H., Wu, Y., Ticer, T. D., Schutt, S. D., Bastian, D. A., Choi, H.-J., Tian, L., Mealer, C., Liu, C., Westwater, C., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.136841 · Cited by 93 · see citing works
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Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes
Liao, C., Rolling, T., Djuković, A., Fei, T., Mishra, V., Liu, H., Lindberg, C., Dai, L., Zhai, B., Peled, J. U., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01680-3 · Cited by 94 · see citing works
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Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg/Th17 Balance in Allo-HSCT Recipients
Han, L., Jin, H., Zhou, L., Zhang, X., Fan, Z., Dai, M., Lin, Q., Huang, F., Xuan, L., Zhang, H., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00669 · Cited by 93 · see citing works
Advances in understanding the pathogenesis of graft‐versus‐host disease
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Authors: Shono, Y., Docampo, M. D., Peled, J. U., Perobelli, S. M., Velardi, E., Tsai, J. J., Slingerland, A. E., Smith, O. M., Young, L. F., Gupta, J., Lieberman, S. R., Jay, H. V., Ahr, K. F., Porosnicu Rodriguez, K. A., Xu, K., Calarfiore, M., Poeck, H., Caballero, S., Devlin, S. M., Rapaport, F., Dudakov, J. A., Hanash, A. M., Gyurkocza, B., Murphy, G. F., Gomes, C., Liu, C., Moss, E. L., Falconer, S. B., Bhatt, A. S., Taur, Y., Pamer, E. G., van den Brink, M. R. M., & Jenq, R. R.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Brigham and Women's Hospital (US)
Rutgers, The State University of New Jersey (US)
Stanford University (US)
Corresponding author: Shono, Yusuke
Jenq, Robert R.
ORCID: Shono, Yusuke
Docampo, Melissa D.
Peled, Jonathan U.
Perobelli, Suelen M.
Velardi, Enrico
Tsai, Jennifer J.
Slingerland, Ann E.
Young, Lauren F.
Lieberman, Sophia R.
Ahr, Katya F.
Xu, Ke
Poeck, Hendrik
Devlin, Sean M.
Dudakov, Jarrod A.
Hanash, Alan M.
Gyurkocza, Boglarka
Gomes, Camilla
Liu, Chen
Bhatt, Ami S.
Taur, Ying
Pamer, Eric G.
Jenq, Robert R.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2016-05-18
Volume: 8
Issue: 339
Pages: 339ra71-339ra71
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aaf2311
PMC: PMC4991773
OpenAlex: W2407774696
Cited by: 592
References: 78
Citations by year: 2026: 49 · 2025: 70 · 2024: 47 · 2023: 61 · 2022: 58 · 2021: 81 · 2020: 65 · 2019: 50 · 2018: 50 · 2017: 47 · 2016: 14
FWCI: 51.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders: NIH (R01-HL069929, R01-AI100288, R01-AI080455, R01-AI101406, R00-CA176376, R01-HL124112)
Radiation Effects Research Foundation_National Institute of Allergy and Infectious Diseases
American Society for Blood and Marrow Transplantation
Australian National Health
Medical Research Council
American Society of Hematology
DKMS (German Bone Marrow Donor Center) Foundation for Giving Life
Lymphoma Foundation
NCI (P30-CA008748)
NIH Cancer Center Support (P30 CA008748-48)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: graft-versus-host disease, allogeneic hematopoietic stem cell transplantation, broad-spectrum antibiotics, imipenem/cilastatin, piperacillin-tazobactam, aztreonam, cefepime, febrile neutropenia, gut microbiota, Akkermansia muciniphila, intestinal mucus barrier, intestinal barrier function, short-chain fatty acids, regulatory T cells
MeSH terms: Gastrointestinal Microbiome, Piperacillin, Tazobactam Drug Combination, Cilastatin, Imipenem Drug Combination, Animals, Anti-Bacterial Agents, Colon, Drug Combinations, Feces, Female, Flow Cytometry, Graft vs Host Disease, Humans, Mice, Inbred C57BL, Penicillanic Acid, Phylogeny, Piperacillin, Transplantation, Homologous, Cilastatin, Imipenem, CD4-Positive T-Lymphocytes, Hematopoietic Stem Cell Transplantation, Mice, Interleukin-23, Verrucomicrobia

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Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

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