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Cited by 505Cancer survivorship and careWomen's cancer prevention and managementChildhood Cancer Survivors' Quality of Life

Quality of life at the end of primary treatment of breast cancer: first results from the moving beyond cancer randomized trial

Ganz, P. A., Kwan, L., Stanton, A. L., Krupnick, J. L., Rowland, J. H., Meyerowitz, B. E., Bower, J. E., Belin, T. R.·2004·JNCI Journal of the National Cancer Institute
DOI 10.1093/jnci/djh060
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Abstract

BACKGROUND: During the last decade, survival rates for breast cancer have increased as a result of earlier detection and increased use of adjuvant therapy. Limited data exist on the psychosocial aspects of the transitional period between the end of primary treatment and survivorship. We investigated the baseline psychosocial status of women enrolled in a randomized trial testing two psychosocial interventions for women at the end of primary treatment. METHODS: Participants, identified within 1 month after surgery (registration), provided demographic information and limited measures of quality of life. They were followed until they finished primary treatment (enrollment), at which time they completed a mailed baseline survey that included standardized measures of quality of life (including standardized scales of physical and emotional functioning), mood, symptoms, and sexual functioning. A total of 558 patients (mean age = 56.9 years) were enrolled in the study between July 1, 1999, and June 30, 2002. Health outcomes were examined according to treatment received: mastectomy with and without chemotherapy, and lumpectomy with and without chemotherapy. All statistical tests were two-sided. RESULTS: Among all treatment groups, patients who had a mastectomy had the poorest physical functioning at registration (P<.001) and at enrollment (P=.05). At enrollment, mood and emotional functioning were similar among all patients, with no differences by type of treatment received. At enrollment, symptoms, including muscle stiffness, breast sensitivity, aches and pains, tendency to take naps, and difficulty concentrating, were common among patients in all groups and were statistically significantly associated with poor physical functioning and emotional well-being. Sexual functioning was worse for women who received chemotherapy than for those who did not, regardless of type of surgery (P<.001). CONCLUSIONS: At the end of primary treatment for breast cancer, women in all treatment groups report good emotional functioning but report decreased physical functioning, particularly among women who have a mastectomy or receive chemotherapy. Clinical interventions to address common symptoms associated with treatment should be considered to improve physical and emotional functioning at the end of primary treatment for breast cancer.

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  • A variety of interventions and changes to the organization and functioning of medical practice have proven to help patients meet their needs and improve care and outcomes across chronic diseases.

    “A variety of interventions and changes to the organization and functioning of medical practice have proven to help patients meet their needs and to improve care and outcomes across chronic diseases26-29.”

    From Self-management: Enabling and empowering patients living with cancer as a chronic illness (2011) · cites this paper as [26]

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Authors
Ganz, P. A., Kwan, L., Stanton, A. L., Krupnick, J. L., Rowland, J. H., Meyerowitz, B. E., Bower, J. E., & Belin, T. R.
Affiliations
  • University of California, Los Angeles (US)
  • University of Southern California (US)
Corresponding author
Ganz, P. A.
ORCID
Venue
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2004-03-02
Volume
96
Issue
5
Pages
376-387
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/djh060
OpenAlex
W2138355767
Cited by
505
References
70
Citations by year
2026: 6 · 2025: 12 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 23 · 2020: 9 · 2019: 19 · 2018: 17 · 2017: 19 · 2016: 19 · 2015: 22 · 2014: 27 · 2013: 34 · 2012: 42
FWCI
14.29
Type
journal article
Language
en
Open access
closed
Locations
  • JNCI Journal of the National Cancer Institute (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R01CA063028)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Keywords
breast cancer, quality of life, breast cancer survivorship, psychosocial functioning, physical function, emotional functioning, sexual function, chemotherapy side effects, mastectomy, breast-conserving surgery
MeSH terms
Adult, Affect, Aged, Breast Neoplasms, Depression, Female, Health Status, Humans, Mastectomy, Middle Aged, Patient Education as Topic, Quality of Life, Surveys and Questionnaires, Regression Analysis, Research Design, Sexual Behavior, Treatment Outcome, Chemotherapy, Adjuvant, Patient Selection, Radiotherapy, Adjuvant

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