Cited by 127Esophageal Cancer Research and TreatmentCancer Cells and MetastasisIdentification and Quantification in Food

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Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

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Boonstra, Jurjen J., van Marion, Ronald, Beer, David G., Lin, Lin, Chaves, Paula, Ribeiro, Catarina, Pereira, A. Dias, Roque, Lúcia, Darnton, S. Jane, Altorki, Nasser K., Schrump, David S., Klimstra, David S., Tang, Laura H., Eshleman, James R., Alvarez, Hector, Shimada, Yutaka, van Dekken, Herman, Tilanus, Hugo W., Dinjens, Winand N. M.·2010·JNCI: Journal of the National Cancer Institute

DOI 10.1093/jnci/djp499PMC PMC2902814

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Abstract

For decades, hundreds of different human tumor type-specific cell lines have been used in experimental cancer research as models for their respective tumors. The veracity of experimental results for a specific tumor type relies on the correct derivation of the cell line. In a worldwide effort, we verified the authenticity of all available esophageal adenocarcinoma (EAC) cell lines. We proved that the frequently used cell lines SEG-1 and BIC-1 and the SK-GT-5 cell line are in fact cell lines from other tumor types. Experimental results based on these contaminated cell lines have led to ongoing clinical trials recruiting EAC patients, to more than 100 scientific publications, and to at least three National Institutes of Health cancer research grants and 11 US patents, which emphasizes the importance of our findings. Widespread use of contaminated cell lines threatens the development of treatment strategies for EAC.

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Cancer Statistics, 2008
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716
Short tandem repeat profiling provides an international reference standard for human cell lines
Masters, J. R., Thomson, J. A., Daly-Burns, B., Reid, Y. A., Dirks, W. G., Packer, P., Toji, L. H., Ohno, T., Tanabe, H., Arlett, C. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121616198 · Cited by 478
Human cancer cell lines: fact and fantasy
Masters, J. R. W. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043102 · Cited by 352
Cross-contamination of cells in culture
Nelson-Rees, W. A., Daniels, D. W., & Flandermeyer, R. R. (1981) · Science · doi:10.1126/science.6451928 · Cited by 329
Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus
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Focus on Barrett's esophagus and esophageal adenocarcinoma
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Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization
Rockett, J. C., Larkin, K., Darnton, S. J., Morris, A. G., & Matthews, H. R. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.42 · Cited by 114
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Shammas, M. A., Koley, H., Batchu, R. B., Bertheau, R. C., Protopopov, A. I., Munshi, N. C., & Goyal, R. K. (2005) · Molecular Cancer · doi:10.1186/1476-4598-4-24 · Cited by 96
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Fu, J., Cheng, J., Li, J., Li, J., Wei, C., Zheng, X., He, T., & Fu, J. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4438-7 · Cited by 16
Do we really know how many clinical trials are conducted ethically? Why research ethics committee review practices need to be strengthened and initial steps we could take to strengthen them
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Authors: Boonstra, J. J., van Marion, R., Beer, D. G., Lin, L., Chaves, P., Ribeiro, C., Pereira, A. D., Roque, L., Darnton, S. J., Altorki, N. K., Schrump, D. S., Klimstra, D. S., Tang, L. H., Eshleman, J. R., Alvarez, H., Shimada, Y., van Dekken, H., Tilanus, H. W., & Dinjens, W. N. M.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Boonstra, Jurjen J.
van Marion, Ronald
Beer, David G.
Chaves, Paula
Ribeiro, Catarina
Pereira, A. Dias
Roque, Lúcia
Altorki, Nasser K.
Schrump, David S.
Klimstra, David S.
Tang, Laura H.
Eshleman, James R.
Shimada, Yutaka
Dinjens, Winand N. M.
Venue: JNCI: Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 2010-02-24
Volume: 102
Issue: 4
Pages: 271-274
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/djp499
PMC: PMC2902814
OpenAlex: W2120608850
Cited by: 127
References: 23
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 17 · 2012: 11
FWCI: 18.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
HighWire Press Open Archive (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion)
Funders: National Cancer Institute (R01CA071606, R01CA154365)
Topics: Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Identification and Quantification in Food
Keywords: esophageal adenocarcinoma, cell line contamination, cell line authentication, cancer research models
MeSH terms: Sorafenib, Adenocarcinoma, Antineoplastic Agents, Benzenesulfonates, Carcinoma, Clinical Trials as Topic, Esophageal Neoplasms, Humans, Lung Neoplasms, National Institutes of Health (U.S.), Niacinamide, Oligonucleotides, Oligopeptides, Phenylurea Compounds, Pyridines, Stomach Neoplasms, United States, Colorectal Neoplasms, DNA Fingerprinting, Carcinoma, Large Cell, Telomerase, Tandem Repeat Sequences, Biomedical Research, Cell Line, Tumor, Protein Kinase Inhibitors

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Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

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