The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Human Papillomavirus Testing in the Prevention of Cervical Cancer
Open accessAbstract
Strong evidence now supports the adoption of cervical cancer prevention strategies that explicitly focus on persistent infection with the causal agent, human papillomavirus (HPV). To inform an evidence-based transition to a new public health approach for cervical cancer screening, we summarize the natural history and cervical carcinogenicity of HPV and discuss the promise and uncertainties of currently available screening methods. New HPV infections acquired at any age are virtually always benign, but persistent infections with one of approximately 12 carcinogenic HPV types explain virtually all cases of cervical cancer. In the absence of an overtly persistent HPV infection, the risk of cervical cancer is extremely low. Thus, HPV test results predict the risk of cervical cancer and its precursors (cervical intraepithelial neoplasia grade 3) better and longer than cytological or colposcopic abnormalities, which are signs of HPV infection. The logical and inevitable move to HPV-based cervical cancer prevention strategies will require longer screening intervals that will disrupt current gynecologic and cytology laboratory practices built on frequent screening. A major challenge will be implementing programs that do not overtreat HPV-positive women who do not have obvious long-term persistence of HPV or treatable lesions at the time of initial evaluation. The greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment.
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Cites
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Cited by
Integrated genomic and molecular characterization of cervical cancer
The Cancer Genome Atlas Research Network (2017) · Nature · doi:10.1038/nature21386 · Cited by 1,479
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Cervical Cancer Prevention in Low- and Middle-Income Countries: Feasible, Affordable, Essential
Sahasrabuddhe, V. V., Parham, G. P., Mwanahamuntu, M. H., & Vermund, S. H. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0540 · Cited by 131
Metadata
- Authors
- Schiffman, M., Wentzensen, N., Wacholder, S., Kinney, W., Gage, J. C., & Castle, P. E.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-31
- Volume
- 103
- Issue
- 5
- Pages
- 368-383
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2156793931
- Cited by
- 759
- References
- 134
- FWCI
- 50.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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