The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Blood-Brain Barrier and Its Role in Immune Privilege in the Central Nervous System
Abstract
The blood-brain barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), strictly regulating the entry of many substances and blood borne cells into the nervous tissue. Increased understanding of how the unique microenvironment in the CNS influences the BBB is crucial for developing novel therapeutic approaches to CNS diseases. In this review, we discuss those characteristics of the BBB that play an important role in maintaining immune privilege in the CNS, as well as factors that regulate immune cell invasion through the BBB and thereby modulate immune responses in the nervous tissue. In general, immune cell invasion across the BBB is highly restricted and carefully regulated. A florid invasion of activated white blood cells can create a predominantly proinflammatory local environment in the CNS, leading to immune-mediated diseases of the nervous tissue. Recent developments in cellular and molecular biological methods have allowed closer analysis of BBB function, and led to an improved understanding of the active role of the BBB in immune-mediated diseases of the CNS.
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Cites
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Cited by
Shaverdian, N., Lisberg, A. E., Bornazyan, K., Veruttipong, D., Goldman, J. W., Formenti, S. C., Garon, E. B., & Lee, P. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30380-7 · Cited by 1,091
Regulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800
Tissue–electronics interfaces: from implantable devices to engineered tissues
Feiner, R., & Dvir, T. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.76 · Cited by 595
Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P., Piontek, J., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8329com · Cited by 347
Neuroinflammation after intracerebral hemorrhage
Mracsko, E., & Veltkamp, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00388 · Cited by 344
Metadata
- Authors
- Pachter, J. S., de Vries, H. E., & Fabry, Z.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06
- Volume
- 62
- Issue
- 6
- Pages
- 593-604
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W50954628
- Cited by
- 294
- References
- 7
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pachter, J. S., de Vries, H. E., & Fabry, Z. (2003). The Blood-Brain Barrier and Its Role in Immune Privilege in the Central Nervous System. Journal of Neuropathology & Experimental Neurology. https://doi.org/10.1093/jnen/62.6.593
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
