Cited by 162Meta-analysis and systematic reviewsStatistical Methods in Clinical TrialsEthics in Clinical Research

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Attrition in Randomized Controlled Trials for Pediatric Chronic Conditions

Karlson, C. W., Rapoff, M. A.·2009·Journal of Pediatric Psychology

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Abstract

OBJECTIVE: To examine attrition variables in randomized controlled trials of cognitive behavioral interventions for children with chronic illnesses. METHODS: We examined attrition rates reported on 40 randomized cognitive behavioral interventions published in six pediatric research journals, during the years 2002-2007. Intervention focus was limited to children with a chronic medical condition, such as asthma, obesity, arthritis, diabetes, cancer, sickle cell disease, and cystic fibrosis. RESULTS: Mean rate of enrollment refusal was 37% (range 0-75%). Mean attrition rate was 20% (range 0-54%) for initial follow-up and 32% (range 0-59%) for extended follow-up. Of the reviewed articles, 40% included a CONSORT diagram. CONCLUSIONS: Strategies that can be used to limit attrition include tailoring recruitment to the study population, providing personalized feedback, maintaining consistent study procedures, providing incentives, and using intensive tracking measures. There is a need for standardized definitions and reporting of attrition rates in randomized cognitive behavioral intervention studies.

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Authors: Karlson, C. W., & Rapoff, M. A.
Affiliations: University of Kansas (US)
ORCID: Karlson, C. W.
Venue: Journal of Pediatric Psychology
Publisher: Oxford University Press (OUP)
Published: 2008-12-08
Volume: 34
Issue: 7
Pages: 782-793
ISSN: 0146-8693 (ISSN-L)
1465-735X
DOI: 10.1093/jpepsy/jsn122
OpenAlex: W2117776447
Cited by: 162
References: 72
Citations by year: 2026: 5 · 2025: 5 · 2024: 10 · 2023: 15 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 10 · 2012: 10
FWCI: 4.53
Type: journal article
Language: en
Open access: closed
Locations: Journal of Pediatric Psychology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Keywords: attrition, randomized controlled trials, pediatric chronic conditions, cognitive-behavioral intervention, children, attrition rates, CONSORT flow diagram, reporting guidelines, recruitment strategies, incentives, asthma, cystic fibrosis, sickle cell disease, diabetes mellitus, obesity, arthritis, childhood cancer
MeSH terms: Analysis of Variance, Child, Chronic Disease, Follow-Up Studies, Humans, Pediatrics, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Patient Selection, Research Subjects

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Attrition in Randomized Controlled Trials for Pediatric Chronic Conditions

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