Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works

Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults

Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806043382302 · Cited by 4,032 · see citing works

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works

Prevalence of a Metabolic Syndrome Phenotype in Adolescents: Findings From the Third National Health and Nutrition Examination Survey, 1988-1994

Cook, S., Weitzman, M., Auinger, P., Nguyen, M., & Dietz, W. H. (2003) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.157.8.821 · Cited by 2,326 · see citing works

Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease

Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340 · see citing works

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J., & Hintze, T. H. (1994) · Circulation Research · doi:10.1161/01.res.74.2.349 · Cited by 934 · see citing works

Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.12.1351 · Cited by 896 · see citing works

Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study

Tounian, P., Aggoun, Y., Dubern, B., Varille, V., Guy-grand, B., Sidi, D., Girardet, J.-P., & Bonnet, D. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06525-4 · Cited by 813 · see citing works

Obesity Accelerates the Progression of Coronary Atherosclerosis in Young Men

McGill, H. C., McMahan, C. A., Herderick, E. E., Zieske, A. W., Malcom, G. T., Tracy, R. E., & Strong, J. P. (2002) · Circulation · doi:10.1161/01.cir.0000018121.67607.ce · Cited by 684 · see citing works

Assessing obesity: classification and epidemiology

Seidell, J. C., & Flegal, K. M. (1997) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011611 · Cited by 499 · see citing works

Exercise training enhances endothelial function in young men

Clarkson, P., Montgomery, H., Mullen, M. J., Donald, A. E., Powe, A. J., Bull, T., Jubb, M., WORLD, M. J., & Deanfield, J. E. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00036-4 · Cited by 458 · see citing works

Effects of Diet and Exercise on Obesity-Related Vascular Dysfunction in Children

Woo, K. S., Chook, P., Yu, C. C.-W., Sung, R. Y. T., Qiao, M., Leung, S. S. F., Lam, C. W. K., Metreweli, C., & Celermajer, D. S. (2004) · Circulation · doi:10.1161/01.cir.0000126599.47470.be · Cited by 455 · see citing works

C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors

Cook, D. G., Mendall, M. A., Whincup, P. H., Carey, I. M., Ballam, L., Morris, J. E., Miller, G. J., & Strachan, D. P. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00312-3 · Cited by 446 · see citing works

Low-Grade Systemic Inflammation in Overweight Children

Visser, M., Bouter, L. M., McQuillan, G. M., Wener, M. H., & Harris, T. B. (2001) · PEDIATRICS · doi:10.1542/peds.107.1.e13 · Cited by 402 · see citing works

Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease

Kaiser, D. R., Billups, K. L., Mason, C., Wetterling, R. A., Lundberg, J. L., & Bank, A. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.042 · Cited by 358 · see citing works

Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents

Watts, K., Beye, P., Siafarikas, A., Davis, E. A., Jones, T. W., O’Driscoll, G., & GREEN, D. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.01.032 · Cited by 356 · see citing works

Metabolic precursors and effects of obesity in children: a decade of progress, 1990–1999

Goran, M. I. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.158 · Cited by 252 · see citing works

C-reactive protein and body mass index in children: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994

Ford, E. S., Galuska, D. A., Gillespie, C., Will, J. C., Giles, W. H., & Dietz, W. H. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.112898 · Cited by 247 · see citing works

Insulin resistance syndrome in childhood: Associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors

Sinaiko, A. R., Jacobs, D. R., Steinberger, J., Moran, A., Luepker, R. V., Rocchini, A. P., & Prineas, R. J. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.118535 · Cited by 213 · see citing works

Effects of exercise training on vascular function in obese children

Watts, K., Beye, P., Siafarikas, A., O’Driscoll, G., Jones, T. W., Davis, E. A., & GREEN, D. J. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.02.027 · Cited by 211 · see citing works

C-Reactive Protein Is Independently Associated With Fasting Insulin in Nondiabetic Women

Pradhan, A. D., Cook, N. R., Buring, J. E., Manson, J. E., & Ridker, P. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000065636.15310.9c · Cited by 211 · see citing works

C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women

Pannacciulli, N., Cantatore, F. P., Minenna, A., Bellacicco, M., GIORGINO, R., & Pergola, G. D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801719 · Cited by 209 · see citing works

Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations

GREEN, D. J., Walsh, J. H., Maiorana, A., Best, M. J., Taylor, R. R., & O'Driscoll, J. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00519.2003 · Cited by 178 · see citing works

Brachial artery dilatation responses in healthy children and adolescents

Järvisalo, M. J., Rönnemaa, T., Volanen, I., Kaitosaari, T., Kallio, K., Hartiala, J., Irjala, K. M. A., Viikari, J. S. A., Simell, O., & Raitakari, O. T. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2002.282.1.h87 · Cited by 106 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

Progress and Challenges in Metabolic Syndrome in Children and Adolescents

Steinberger, J., Daniels, S. R., Eckel, R. H., Hayman, L. L., Lustig, R. H., McCrindle, B. W., & Mietus‐Snyder, M. (2009) · Circulation · doi:10.1161/circulationaha.108.191394 · Cited by 713 · see citing works

Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: <i>Endorsed by the American Academy of Pediatrics</i>

Kavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2006) · Circulation · doi:10.1161/circulationaha.106.179568 · Cited by 707 · see citing works

Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents

Urbina, E. M., Williams, R. V., Alpert, B. S., Collins, R. T., Daniels, S. R., Hayman, L. L., Jacobson, M., Mahoney, L. T., Mietus‐Snyder, M., Rocchini, A. P., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.192639 · Cited by 642 · see citing works

Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls

Nassis, G. P., Papantakou, K., Skenderi, K., Triandafillopoulou, M., Kavouras, S. A., Yannakoulia, M., Chrousos, G. P., & Sidossis, L. S. (2005) · Metabolism · doi:10.1016/j.metabol.2005.05.013 · Cited by 468 · see citing works

Improvement of Early Vascular Changes and Cardiovascular Risk Factors in Obese Children After a Six-Month Exercise Program

Meyer, A. A., Kundt, G., Lenschow, U., Schuff‐Werner, P., & Kienast, W. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.035 · Cited by 430 · see citing works

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Balagopal, P., de Ferranti, S. D., Cook, S., Daniels, S. R., Gidding, S. S., Hayman, L. L., McCrindle, B. W., Mietus‐Snyder, M., & Steinberger, J. (2011) · Circulation · doi:10.1161/cir.0b013e31821c7c64 · Cited by 353 · see citing works

Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials

Fedewa, M. V., Hathaway, E. D., & Ward-Ritacco, C. L. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-095999 · Cited by 309 · see citing works

Impaired Flow-Mediated Vasodilation, Carotid Artery Intima-Media Thickening, and Elevated Endothelial Plasma Markers in Obese Children: The Impact of Cardiovascular Risk Factors

Meyer, A. A., Kundt, G., Steiner, M., Schuff‐Werner, P., & Kienast, W. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2140 · Cited by 278 · see citing works

Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents

Platat, C., Drai, J., Oujaa, M., Schlienger, J.-L., & Simon, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1178 · Cited by 263 · see citing works

Fitness Measures and Health Outcomes in Youth

Institute of Medicine (2012) · National Academies Press eBooks · doi:10.17226/13483 · Cited by 263 · see citing works

Reduction of Elevated Serum Retinol Binding Protein in Obese Children by Lifestyle Intervention: Association with Subclinical Inflammation

Balagopal, P., Graham, T. E., Kahn, B. B., Altomare, A., Funanage, V. L., & George, D. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2712 · Cited by 234 · see citing works

Obesity and low‐grade inflammation: a paediatric perspective

Tam, C. S., Clément, K., Baur, L. A., & Tordjman, J. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00674.x · Cited by 200 · see citing works

Lifetime risk: childhood obesity and cardiovascular risk

Ayer, J. G., Charakida, M., Deanfield, J. E., & Celermajer, D. S. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv089 · Cited by 191 · see citing works

Exercise and Insulin Resistance in Youth: A Meta-Analysis

Fedewa, M. V., Gist, N. H., Evans, E. M., & Dishman, R. K. (2013) · PEDIATRICS · doi:10.1542/peds.2013-2718 · Cited by 181 · see citing works

Exercise, Inflammation, and Innate Immunity

Woods, J. A., Vieira‐Potter, V. J., & Keylock, K. T. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.011 · Cited by 176 · see citing works

Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children

Murphy, E., Carson, L. M., Neal, W., Baylis, C., Donley, D., & YEATER, R. A. (2009) · International Journal of Pediatric Obesity · doi:10.3109/17477160902846187 · Cited by 174 · see citing works

Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: markers and effect of lifestyle intervention

Montero, D., Walther, G., Pérez‐Martin, A., Roche, E., & Vinet, A. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00956.x · Cited by 166 · see citing works

In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children

Kelly, A. S., Steinberger, J., Olson, T. P., & Dengel, D. R. (2007) · Metabolism · doi:10.1016/j.metabol.2007.03.009 · Cited by 165 · see citing works

Cardiovascular disease in childhood: the role of obesity

Herouvi, D., Karanasios, E., Karayianni, C., & Karavanaki, K. (2013) · European Journal of Pediatrics · doi:10.1007/s00431-013-1932-8 · Cited by 163 · see citing works

Attrition in Randomized Controlled Trials for Pediatric Chronic Conditions

Karlson, C. W., & Rapoff, M. A. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn122 · Cited by 162 · see citing works

Physical activity, sport, and pediatric diabetes

Riddell, M. C., & Iscoe, K. E. (2006) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2006.00146.x · Cited by 157 · see citing works

Effects of aerobic, resistance, and combined exercise training on insulin resistance markers in overweight or obese children and adolescents: A systematic review and meta-analysis

Marson, E. C., Delevatti, R. S., Prado, A. K. G., Netto, N. D. S., & Kruel, L. F. M. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.10.020 · Cited by 164 · see citing works

Vascular ageing: moving from bench towards bedside

Climie, R. E., Alastruey, J., Mayer, C. C., Schwarz, A., Laučytė-Cibulskienė, A., Voicehovska, J., Bianchini, E., Bruno, R. M., Charlton, P. H., Grillo, A., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad028 · Cited by 139 · see citing works

Cardiovascular Consequences of Childhood Obesity

McCrindle, B. W. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.08.017 · Cited by 138 · see citing works

Council on Nutrition, Physical Activity, and Metabolism Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Hypertension, and Obesity in the Young Committee of the Council on Scientific Statement From the American Heart Association Atherosclerosis, Progress and Challenges in Metabolic Syndrome in Children and Adolescents. A

McCrindle, B. W., Mietus‐Snyder, M., Steinberger, J., Daniels, S. R., Eckel, R. H., & Hayman, L. L. (2009) · Cited by 138 · see citing works

Effect of a short-term diet and exercise intervention on metabolic syndrome in overweight children

Chen, A. K., Roberts, C. K., & Barnard, R. J. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.001 · Cited by 134 · see citing works

Obesity, Metabolic Syndrome, and Cardiovascular Disease

Aggoun, Y. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31805d8a8c · Cited by 134 · see citing works

The relative influences of fitness and fatness on inflammatory factors

Hamer, M. (2006) · Preventive Medicine · doi:10.1016/j.ypmed.2006.09.005 · Cited by 132 · see citing works

Pediatric Precursors of Adult Cardiovascular Disease: Noninvasive Assessment of Early Vascular Changes in Children and Adolescents

Groner, J. A., Joshi, M. S., & Bauer, J. A. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2992 · Cited by 122 · see citing works

Exercise, Inflammation, and Innate Immunity

Woods, J. A., Vieira‐Potter, V. J., & Keylock, K. T. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.008 · Cited by 117 · see citing works

Associations of low-grade inflammation with physical activity, fitness and fatness in prepubertal children; the European Youth Heart Study

Ruiz, J. R., Ortega, F. B., Wärnberǵ, J., & Sjöstróm, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803693 · Cited by 107 · see citing works

Physical activity, exercise and low-grade systemic inflammation

Wärnberǵ, J., Cunningham, K., Romeo, J., & Marcos, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001928 · Cited by 108 · see citing works

Aerobic exercise and lipids and lipoproteins in children and adolescents: A meta-analysis of randomized controlled trials

Kelley, G. A., & Kelley, K. S. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.019 · Cited by 108 · see citing works

Elevated total and central adiposity and low physical activity are associated with insulin resistance in children

Krekoukia, M., Nassis, G. P., Psarra, G., Skenderi, K., Chrousos, G. P., & Sidossis, L. S. (2007) · Metabolism · doi:10.1016/j.metabol.2006.09.014 · Cited by 107 · see citing works

Arterial function in youth: window into cardiovascular risk

Fernhall, B., & Agiovlasitis, S. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00001.2008 · Cited by 105 · see citing works

Low-grade inflammation and the metabolic syndrome in children and adolescents

Wärnberǵ, J., & Marcos, A. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f4096b · Cited by 103 · see citing works

Morphologic and metabolic abnormalities in vertically HIV-infected children and youth

Aldrovandi, G. M., Lindsey, J. C., Jacobson, D. L., Zadzilka, A., Sheeran, E., Moye, J., Borum, P. R., Meyer, W. A., Hardin, D. S., & Mulligan, K. M. (2009) · AIDS · doi:10.1097/qad.0b013e3283269dfb · Cited by 102 · see citing works

Higher Self-reported Physical Activity Is Associated With Lower Systolic Blood Pressure: The Dietary Intervention Study in Childhood (DISC)

Gidding, S. S., BARTON, B. A., Dorgan, J. A., Kimm, S. Y. S., Kwiterovich, P. O., Lasser, N. L., Robson, A. M., Stevens, V. J., Horn, L. V., & Simons‐Morton, D. G. (2006) · PEDIATRICS · doi:10.1542/peds.2006-1785 · Cited by 100 · see citing works

Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors

Roberts, C. K., Chen, A. K., & Barnard, R. J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.09.011 · Cited by 97 · see citing works

Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis

Wang, S., Zhou, H., Zhao, C., & He, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.921085 · Cited by 100 · see citing works

Altitude, exercise and immune function.

Mazzeo, R. S. (2005) · PubMed · Cited by 92 · see citing works

Associations between cardiorespiratory fitness, physical activity and clustered cardiometabolic risk in children and adolescents: the HAPPY study

Bailey, D. P., Boddy, L. M., Savory, L. A., Denton, S. J., & Kerr, C. J. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-012-1719-3 · Cited by 91 · see citing works

Vascular Endothelial and Smooth Muscle Function Relates to Body Mass Index and Glucose in Obese and Nonobese Children

Peña, A. S., Wiltshire, E. J., MacKenzie, K. E., Gent, R. J., Piotto, L., Hirte, C., & Couper, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0863 · Cited by 86 · see citing works

Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D–deficient overweight and obese children: a randomized clinical trial

Rajakumar, K., Moore, C. G., Khalid, A. T., Vallejo, A. N., Virji, M. A., Holick, M. F., Greenspan, S. L., Arslanian, S. A., & Reís, S. E. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz340 · Cited by 82 · see citing works

Childhood Obesity, Diabetes, and Cardiovascular Disease Risk

Salama, M., Balagopal, B., Fennoy, I., & Kumar, S. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad361 · Cited by 89 · see citing works

Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review

Petek, T. H., Petek, T. H., Močnik, M., & Varda, N. M. (2022) · Antioxidants · doi:10.3390/antiox11050894 · Cited by 89 · see citing works

Obesity and inflammation in children

Schwarzenberg, S. J., & Sinaiko, A. R. (2006) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2006.08.002 · Cited by 78 · see citing works

Prevention of overweight and obesity in children under the age of 6 yearsA report commissioned by the Canadian Council of Food and Nutrition.

Olstad, D. L., & McCargar, L. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-016 · Cited by 80 · see citing works

Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels

McMurray, R. G., Bangdiwala, S. I., Harrell, J. S., & Amorim, L. D. A. F. (2008) · Dynamic Medicine · doi:10.1186/1476-5918-7-5 · Cited by 80 · see citing works

Vascular Endothelial Function and Leisure-Time Physical Activity in Adolescents

Pahkala, K., Heinonen, O. J., Lagström, H., Hakala, P., Simell, O., Viikari, J. S. A., Rönnemaa, T., Hernelahti, M., Sillanmäki, L. H., & Raitakari, O. T. (2008) · Circulation · doi:10.1161/circulationaha.108.791988 · Cited by 80 · see citing works

Inflammatory Proteins and Muscle Strength in Adolescents: The AVENA Study

Ruiz, J. R., Ortega, F. B., Wärnberg, J., Moreno, L. A., Carrero, J. J., Gonzalez-Gross, M., Marcos, A., Gutierrez, A., & Sjöström, M. (2008) · Archives of Pediatrics &amp; Adolescent Medicine · doi:10.1001/archpedi.162.5.462 · Cited by 78 · see citing works

Effects of exercise on BMI z-score in overweight and obese children and adolescents: a systematic review with meta-analysis

Kelley, G. A., Kelley, K. S., & Pate, R. R. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-225 · Cited by 78 · see citing works

Review of the Relationship between C-Reactive Protein and Exercise

Michigan, A., Johnson, T. V., & Master, V. A. (2011) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256418 · Cited by 75 · see citing works

Exercise and adiposity in overweight and obese children and adolescents: a systematic review with network meta-analysis of randomised trials

Kelley, G. A., Kelley, K. S., & Pate, R. R. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031220 · Cited by 76 · see citing works

Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials

Tao, X., Chen, Y., Zhen, K., Ren, S., Lv, Y., & Yu, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1043108 · Cited by 73 · see citing works

Physical activity and sedentary behavior in adolescents with type 1 diabetes

Michaliszyn, S. F., & Faulkner, M. S. (2010) · Research in Nursing & Health · doi:10.1002/nur.20393 · Cited by 71 · see citing works

The Influence of Physical Activity on Cardiometabolic Biomarkers in Youths: A Review

Gutin, B., & Owens, S. (2011) · Pediatric Exercise Science · doi:10.1123/pes.23.2.169 · Cited by 69 · see citing works

Exercise and BMI in Overweight and Obese Children and Adolescents: A Systematic Review and Trial Sequential Meta-Analysis

Kelley, G. A., Kelley, K. S., & Pate, R. R. (2015) · BioMed Research International · doi:10.1155/2015/704539 · Cited by 72 · see citing works

Lifestyle-related determinants of inflammation in adolescence

Wärnberǵ, J., Nova, E., Romeo, J., Moreno, L. A., Sjöstróm, M., & Marcos, A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507839614 · Cited by 68 · see citing works

Endothelial Function in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Dengel, D. R., Ness, K. K., Glasser, S. P., Williamson, E. B., Baker, K. S., & Gurney, J. G. (2008) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e318159a593 · Cited by 67 · see citing works

Endothelial dysfunction and arterial abnormalities in childhood obesity

Skilton, M. R., & Celermajer, D. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803397 · Cited by 66 · see citing works

Myocardial Tissue Remodeling in Adolescent Obesity

Shah, R. V., Abbasi, S. A., Neilan, T. G., Hulten, E. A., Coelho‐Filho, O. R., Hoppin, A. G., Levitsky, L. L., de Ferranti, S. D., Rhodes, E. T., Traum, A. Z., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000279 · Cited by 64 · see citing works

The Effects of Exercise Training on Brachial Artery Flow-Mediated Dilation

Early, K. S., Stewart, A., Johannsen, N. M., Lavie, C. J., Thomas, J. R., & Welsch, M. A. (2016) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000206 · Cited by 63 · see citing works

Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weight

García‐Hermoso, A., López‐Gil, J. F., Izquierdo, M., Ramírez‐Vélez, R., & Ezzatvar, Y. (2023) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2023.4038 · Cited by 63 · see citing works

Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity

Jae, S. Y., Fernhall, B., Heffernan, K. S., Jeong, M., Chun, E. M., Sung, J., Lee, S. H., Lim, Y. J., & Park, W. H. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.010 · Cited by 60 · see citing works

The Influence of Exercise on Metabolic Syndrome in Youth: A Review

McMurray, R. G., & Andersen, L. B. (2009) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609351234 · Cited by 60 · see citing works

Influence of Physical Activity and Nutrition on Obesity‐Related Immune Function

Huang, C., Zourdos, M. C., Jo, E., & Ormsbee, M. J. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/752071 · Cited by 59 · see citing works

Exercise and Vascular Function in Child Obesity: A Meta-Analysis

Dias, K. A., GREEN, D. J., Ingul, C. B., Pavey, T., & Coombes, J. S. (2015) · PEDIATRICS · doi:10.1542/peds.2015-0616 · Cited by 58 · see citing works

The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation

Gray, S. R., Baker, G., Wright, A., Fitzsimons, C. F., Mutrie, N., & Nimmo, M. A. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2008.10.013 · Cited by 58 · see citing works

Wellness, Not Weight: Changing the Focus in Children and Adolescents

Saul, J., & Rodgers, R. F. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.10.005 · Cited by 57 · see citing works

Physical activity is related to insulin sensitivity in children and adolescents, independent of adiposity: a review of the literature

Berman, L. J., Weigensberg, M. J., & Spruijt‐Metz, D. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2292 · Cited by 56 · see citing works

Cardiovascular Risk Reduction in High-Risk Pediatric Patients*

Kavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2007) · The Journal of Cardiovascular Nursing · doi:10.1097/01.jcn.0000267827.50320.85 · Cited by 55 · see citing works

Exercise and BMI z ‐score in Overweight and Obese Children and Adolescents: A Systematic Review and Network Meta‐Analysis of Randomized Trials

Kelley, G. A., Kelley, K. S., & Pate, R. R. (2016) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12228 · Cited by 57 · see citing works

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Zhang, H., Jiang, L., Yang, Y.-J., Ge, R., Zhou, M. S., Hu, H., Liu, H., Cui, J., Li, L.-L., Dong, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-18086-3 · Cited by 55 · see citing works

Altered hemodynamic regulation and reflex control during exercise and recovery in obese boys

Δίπλα, Κ., Zafeiridis, A., Koidou, E., Geladas, N. D., & Vrabas, I. S. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00087.2010 · Cited by 54 · see citing works

Combined dyslipidemia in childhood

Kavey, R.-E. W. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.06.008 · Cited by 55 · see citing works

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

Madani, A., Alack, K., Richter, M. J., & Krüger, K. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141149 · Cited by 56 · see citing works

Effects of Flaxseed Interventions on Circulating Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Rahimlou, M., Jahromi, N. B., Hasanyani, N., & Ahmadi, A. R. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz048 · Cited by 52 · see citing works

Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements

Bruyndonckx, L., Hoymans, V. Y., Lemmens, K., Ramet, J., & Vrints, C. J. (2016) · Pediatric Research · doi:10.1038/pr.2016.22 · Cited by 53 · see citing works

Impact of exercise training without caloric restriction on inflammation, insulin resistance and visceral fat mass in obese adolescents

Mendelson, M., Michallet, A. ‐., Monneret, D., Perrin, C., Estève, F., Lombard, P. R., Faure, P., Levy, P. A., Favre‐Juvin, A., Pépin, J., et al. (2014) · Pediatric Obesity · doi:10.1111/ijpo.255 · Cited by 51 · see citing works

Effects of Aerobic Exercise on Non–High‐Density Lipoprotein Cholesterol in Children and Adolescents: A Meta‐Analysis of Randomized Controlled Trials

Kelley, G. A., & Kelley, K. S. (2008) · Progress in Cardiovascular Nursing · doi:10.1111/j.1751-7117.2008.00002.x · Cited by 49 · see citing works

Biomarkers for cardiovascular risk in children

Canas, J. A., Sweeten, S., & Balagopal, P. (2013) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32835dd0ce · Cited by 48 · see citing works

Does Regular Exercise without Weight Loss Reduce Insulin Resistance in Children and Adolescents?

Kim, Y., & Park, H.-N. (2013) · International Journal of Endocrinology · doi:10.1155/2013/402592 · Cited by 47 · see citing works

Regulation of Muscle Blood Flow in Obesity

Hodnett, B. L., & Hester, R. L. (2007) · Microcirculation · doi:10.1080/10739680701282143 · Cited by 46 · see citing works

Areca nut chewing and systemic inflammation: evidence of a common pathway for systemic diseases

Shafique, K., Mirza, S. S., Vart, P., Memon, A. R., Arain, M. I., Tareen, M. F., & Haq, Z. U. (2012) · Journal of Inflammation · doi:10.1186/1476-9255-9-22 · Cited by 46 · see citing works

Paediatric exercise immunology: Health and clinical applications

Timmons, B. W. (2026) · PubMed · doi:10.22029/eir.2005.1619 · Cited by 44 · see citing works

Relationships between heart rate variability, vascular function, and adiposity in children

Kaufman, C. L., Kaiser, D. R., Steinberger, J., & Dengel, D. R. (2007) · Clinical Autonomic Research · doi:10.1007/s10286-007-0411-6 · Cited by 43 · see citing works

A Review of the Promotion of Fitness Measures and Health Outcomes in Youth

Stodden, D., Sacko, R. S., & Nesbitt, D. (2015) · American Journal of Lifestyle Medicine · doi:10.1177/1559827615619577 · Cited by 44 · see citing works

Characteristics of physical activity interventions and effects on cardiorespiratory fitness in children aged 6–12 years—A systematic review

Braaksma, P., Stuive, I., Garst, R., Wesselink, C. F., van der Sluis, C. K., Dekker, R., & Schoemaker, M. M. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.07.015 · Cited by 43 · see citing works

The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis

Kazeminasab, F., Sharafifard, F., Miraghajani, M. S., Behzadnejad, N., & Rosenkranz, S. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1178376 · Cited by 40 · see citing works

Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation

Prüller, F., Raggam, R. B., Posch, V., Almer, G., Truschnig-Wilders, M., Horejsi, R., Möller, R., Weghuber, D., Ille, R., Schnedl, W. J., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.09.035 · Cited by 40 · see citing works

Examination of Changes in Youth Diet and Physical Activity Over the Summer Vacation Period

McCue, M. C., Marlatt, K. L., & Sirard, J. R. (2013) · Internet Journal of Allied Health Sciences and Practice · doi:10.46743/1540-580x/2013.1430 · Cited by 40 · see citing works

Age and sex relationship with flow-mediated dilation in healthy children and adolescents

Hopkins, N. D., Dengel, D. R., Stratton, G., Kelly, A. S., Steinberger, J., Zavala, H., Marlatt, K. L., Perry, D. C., Naylor, L. H., & GREEN, D. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01113.2014 · Cited by 40 · see citing works

Does Physical Activity-Based Intervention Improve Systemic Proinflammatory Cytokine Levels in Overweight or Obese Children and Adolescents? Insights from a Meta-Analysis of Randomized Control Trials

Han, Y., Liu, Y., Zhao, Z., Zhen, S., Chen, J., Ding, N., Ma, Y., & Wen, D. (2019) · Obesity Facts · doi:10.1159/000501970 · Cited by 40 · see citing works

Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: Effects of a home-based exercise program

Järvelä, L. S., Niinikoski, H., Heinonen, O. J., Lähteenmäki, P. M., Arola, M. O., & Kemppainen, J. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24565 · Cited by 39 · see citing works

Effects of exercise on insulin sensitivity, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese male adolescents

Shih, K., Janckila, A. J., Kwok, C., Ho, L., Chou, Y., & Chao, T.-Y. (2009) · Metabolism · doi:10.1016/j.metabol.2009.06.035 · Cited by 39 · see citing works

Vascular Ageing in Youth: A Call to Action

Climie, R. E., Park, C. M., Avolio, A. P., Mynard, J. P., Kruger, R., & Bruno, R. M. (2021) · Heart Lung and Circulation · doi:10.1016/j.hlc.2021.06.516 · Cited by 39 · see citing works

Exercise-based interventions and C-reactive protein in overweight and obese youths: a meta-analysis of randomized controlled trials

García‐Hermoso, A., Sánchez‐López, M., Escalante, Y., Saavedra, J. M., & Martínez‐Vizcaíno, V. (2015) · Pediatric Research · doi:10.1038/pr.2015.274 · Cited by 38 · see citing works

Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol

Dias, K. A., Coombes, J. S., GREEN, D. J., Gomersall, S. R., Keating, S. E., Tjønna, A. E., Hollekim-Strand, S. M., Hosseini, M. S., Rø, T. B., Haram, M., et al. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010929 · Cited by 38 · see citing works

The effects of aerobic exercise on inflammatory factors, insulin resistance and endothelial function in overweight or obese children

Zheng, K. (2020) · Zhonghua wuli yixue zazhi · doi:10.3760/cma.j.issn.0254-1424.2020.03.001 · Cited by 2 · see citing works

Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children

Murphy, E., Carson, L. M., Neal, W., Baylis, C., Donley, D., & YEATER, R. A. (2009) · International Journal of Pediatric Obesity · doi:10.3109/17477160902846187 · Cited by 174 · see citing works

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children

Kelishadi, R., Hashemi, M., Mohammadifard, N., Asgary, S., & Khavarian, N. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.089953 · Cited by 124 · see citing works

Evaluation of markers of inflammation, insulin resistance and endothelial dysfunction in children at risk for overweight

Akıncı, G., Akıncı, B., Coşkun, Ş., Bayındır, P., Hekimsoy, Z., & Özmen, B. (2008) · HORMONES · doi:10.1007/bf03401507 · Cited by 41 · see citing works

The effect of aerobic exercise on endothelial dysfunction in overweight children.

Murphy, E. (2007) · doi:10.33915/etd.9475 · Cited by 3 · see citing works