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The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

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McGeoch, Duncan J., Dolan, Aidan, Donald, Sally, Brauer, Dieter H.K.·1986·Nucleic Acids Research

Abstract

We report the complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1, as 6633 base pairs of composition 79.5% G+C. This contains immediate early gene 3, encoding the IE175 protein, an important transcriptional activator of later virus genes. The IE175 coding region was identified as a 3894 base sequence of 81.5% G+C DNA. The base composition of this gene is thus the most extreme yet determined, and the IE175 predicted amino acid composition is correspondingly biased, most notably with an alanine content of 20.9%. Functionally important regions of the IE175 polypeptide were tentatively identified by comparison with the sequence of the homologous protein from varicella-zoster virus and from locations of ts mutations, and were correlated with properties of the amino acid sequence. Aspects of the evolution of such an extreme composition DNA sequence were discussed.

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Metadata

Authors
McGeoch, D. J., Dolan, A., Donald, S., & Brauer, D. H. K.
Venue
Nucleic Acids Research
Published
1986
Volume
14
Issue
4
Pages
1727-1745
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W1964297270
Cited by
332
References
32
FWCI
22.76
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1. https://app.cochat.ai/papers/10.1093/nar/14.4.1727
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McGeoch, D. J., Dolan, A., Donald, S., & Brauer, D. H. K. (1986). Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1. Nucleic Acids Research. https://doi.org/10.1093/nar/14.4.1727

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