Characterization of a UV Endonuclease Gene from the Fisson Yeast Schizosaccharomyces Pombe and Its Bacterial Homolog
Open accessAbstract
From the fission yeast Schizosaccharomyces pombe, a cDNA fragment was isolated, which confers UV resistance on repair deficient Escherichia coli host cells. The cloned cDNA encodes a protein of 68,815 Da, which has a 36.6% identity of amino acid sequence with the previously identified 74 kDa UV endonuclease of the filamentous fungus Neurospora crassa. Analysis of several truncated gene constructs shows that only the C-terminal two thirds region, which has 54% identity of amino acid sequence with the C-terminal region of the Neurospora homolog, is necessary for complementing activity of UV-sensitivity in the E. coli host cells. Purified recombinant protein from E. coli host cells incises both UV-induced cyclobutane pyrimidine dimers and (6-4) photoproducts at the sites immediately 5' to the DNA damage in the same fashion as the Neurospora protein. Furthermore, a bacterial homologous sequence was isolated from Bacillus subtilis and shows a similar complementing activity of UV sensitivity in E. coli host cells, indicating a wide distribution of this alternative excision repair mechanism in life.
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UVDE initiates repair at both dipyrimidine photoproducts by incision immediately 5′ to the damage, followed by long-patch BER in conjunction with Rad27/Fen1, XRCC1, PARP1, and DNA polymerase.
“UVDE initiates repair at both dipyrimidine photoproducts by incision immediately 5′ to the damage18,28,29, followed by long-patch BER in conjunction with Rad27/Fen1, XRCC1, PARP1, and DNA polymerase30–33.”
From Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways (2018) · cites this paper as [29]
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Self-citation
- Authors
- Takao, M., Yonemasu, R., Yamamoto, K., & Yasui, A.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Yasui, A.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-04-01
- Volume
- 24
- Issue
- 7
- Pages
- 1267-1271
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC145772
- OpenAlex
- W2138434854
- Cited by
- 72
- References
- 12
- Citations by year
- 2020: 1 · 2018: 3 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nucleic Acids Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- UV endonuclease, Schizosaccharomyces pombe, Neurospora crassa, Bacillus subtilis, cDNA cloning, UV resistance, DNA repair, cyclobutane pyrimidine dimers, 6-4 photoproducts, gene complementation, amino acid sequence identity, C-terminal domain
- MeSH terms
- Amino Acid Sequence, Bacillus subtilis, Cloning, Molecular, DNA Repair, Endodeoxyribonucleases, Genes, Bacterial, Genes, Fungal, Molecular Sequence Data, Neurospora crassa, Schizosaccharomyces, Sequence Alignment, Sequence Homology, Amino Acid, DNA, Complementary, Schizosaccharomyces pombe Proteins
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