The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials
Open accessAbstract
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.
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The other half of activity endpoints originates from ChEMBLdb and IUPHAR/BPS Guide to Pharmacology.
“The other half originates from ChEMBLdb (27) and the IUPHAR/BPS Guide to Pharmacology (30).”
From DrugCentral 2023 extends human clinical data and integrates veterinary drugs (2023) · cites this paper as [30]
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- Authors
- Harding, S. D., Armstrong, J. F., Faccenda, E., Southan, C., Alexander, S. P. H., Davenport, A. P., Pawson, A. J., Spedding, M., Davies, J. A., & NC-IUPHAR
- Affiliations
- University of Edinburgh (GB)
- University of Nottingham (GB)
- University of Cambridge (GB)
- Spedding Research Solutions SAS, Le Vésinet 78110, France
- Corresponding author
- Harding, Simon D
- ORCID
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-10-30
- Volume
- 50
- Issue
- D1
- Pages
- D1282-D1294
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC8689838
- OpenAlex
- W3209896479
- Cited by
- 149
- References
- 32
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 31 · 2023: 54 · 2022: 32 · 2021: 1
- FWCI
- 15.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- International Union of Basic and Clinical Pharmacology
- British Pharmacological Society (MED791)
- Medicines for Malaria Venture (CT-5535)
- Antibiotic Research UK (ANTSRG 02/2019)
- American Society for Pharmacology and Experimental Therapeutics
- Laboratoires Servier
- University of Edinburgh
- Wellcome Trust
- Topics
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
- Keywords
- GtoPdb, COVID-19 pandemic, SARS-CoV-2, coronavirus proteins, malaria, antibacterial agents, antibiotic resistance, ligand-target interactions
- MeSH terms
- COVID-19, COVID-19 Drug Treatment, Anti-Bacterial Agents, Antimalarials, Antiviral Agents, Humans, Ligands, Malaria, User-Computer Interface, Viral Proteins, Databases, Pharmaceutical, Data Curation
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