Histone deacetylases in fungi: novel members, new facts
Open accessAbstract
Acetylation is the most prominent modification on core histones that strongly affects nuclear processes such as DNA replication, DNA repair and transcription. Enzymes responsible for the dynamic equilibrium of histone acetylation are histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this paper we describe the identification of novel HDACs from the filamentous fungi Aspergillus nidulans and the maize pathogen Cochliobolus carbonum. Two of the enzymes are homologs of Saccharomyces cerevisiae HOS3, an enzyme that has not been identified outside of the established yeast systems until now. One of these homologs, HosB, showed intrinsic HDAC activity and remarkable resistance against HDAC inhibitors like trichostatin A (TSA) when recombinant expressed in an Escherichia coli host system. Phylo genetic analysis revealed that HosB, together with other fungal HOS3 orthologs, is a member of a separate group within the classical HDACs. Immunological investigations with partially purified HDAC activities of Aspergillus showed that all classical enzymes are part of high molecular weight complexes and that a TSA sensitive class 2 HDAC constitutes the major part of total HDAC activity of the fungus. However, further biochemical analysis also revealed an NAD(+)-dependent activity that could be separated from the other activities by different types of chromatography and obviously represents an enzyme of the sirtuin class.
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Analyses of the KDAC activity pattern in fungi revealed important differences among yeasts and molds.
“Analyses of the KDAC activity pattern in fungi revealed important differences among yeasts and molds (39, 40), which could explain these discrepancies.”
From Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus (2014) · cites this paper as [40]
In Aspergillus nidulans, RpdA (class 1) and HdaA (class 2) are major contributors to total KDAC activity.
“In Aspergillus nidulans, RpdA (class 1) and HdaA (class 2) were shown to be the major contributors to the total KDAC activity (40).”
From Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus (2014) · cites this paper as [40]
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- Authors
- Trojer, P.
- Affiliations
- Universität Innsbruck (AT)
- Corresponding author
- Trojer, P.
- ORCID
- Trojer, P.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-07-15
- Volume
- 31
- Issue
- 14
- Pages
- 3971-3981
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC167634
- OpenAlex
- W2113032400
- Cited by
- 86
- References
- 52
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 6 · 2012: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nucleic Acids Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- histone deacetylase, histone acetylation, Aspergillus nidulans, Cochliobolus carbonum, histone deacetylase inhibitors, sirtuins, NAD+-dependent deacetylation, filamentous fungi, histone acetyltransferase
- MeSH terms
- Amino Acid Sequence, Ascomycota, Aspergillus nidulans, DNA, Fungal, Escherichia coli, Histone Deacetylases, Isoenzymes, Molecular Sequence Data, Phylogeny, Precipitin Tests, Recombinant Proteins, Immunoblotting, Gene Expression Regulation, Fungal, Gene Expression Regulation, Enzymologic, Sequence Alignment, Sequence Homology, Amino Acid, Sequence Analysis, DNA
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