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UniPROBE: an online database of protein binding microarray data on protein-DNA interactions

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Newburger, D. E., Bulyk, M. L.·2009·Nucleic Acids Research

Abstract

The UniPROBE (Universal PBM Resource for Oligonucleotide Binding Evaluation) database hosts data generated by universal protein binding microarray (PBM) technology on the in vitro DNA-binding specificities of proteins. This initial release of the UniPROBE database provides a centralized resource for accessing comprehensive PBM data on the preferences of proteins for all possible sequence variants ('words') of length k ('k-mers'), as well as position weight matrix (PWM) and graphical sequence logo representations of the k-mer data. In total, the database hosts DNA-binding data for over 175 nonredundant proteins from a diverse collection of organisms, including the prokaryote Vibrio harveyi, the eukaryotic malarial parasite Plasmodium falciparum, the parasitic Apicomplexan Cryptosporidium parvum, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, mouse and human. Current web tools include a text-based search, a function for assessing motif similarity between user-entered data and database PWMs, and a function for locating putative binding sites along user-entered nucleotide sequences. The UniPROBE database is available at http://thebrain.bwh.harvard.edu/uniprobe/.

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Metadata

Authors
Newburger, D. E., & Bulyk, M. L.
Venue
Nucleic Acids Research
Published
2009-01-01
Volume
37
Issue
Database
Pages
D77-D82
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2161849959
Cited by
367
References
35
FWCI
8.07
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. https://app.cochat.ai/papers/10.1093/nar/gkn660
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Newburger, D. E., & Bulyk, M. L. (2009). UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn660

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