Cited by 104Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms

Open access

Turner, J. D., Pelascini, L. P. L., Macedo, J. A., Muller, C. P.·2008·Nucleic Acids Research

Open this paper in CoChat — free account

Abstract

The transcription start sites (TSS) and promoters of many genes are located in upstream CpG islands. Methylation within such islands is known for both imprinted and oncogenes, although poorly studied for other genes, especially those with complex CpG islands containing multiple first exons and promoters. The glucocorticoid receptor (GR) CpG island contains seven alternative first exons and their promoters. Here we show for the five GR promoters activated in PBMCs that methylation patterns are highly variable between individuals. The majority of positions were methylated at levels >25% in at least one donor affecting each promoter and TSS. We also examined the evolutionarily conserved transcription factor binding sites (TFBS) using an improved in silico phylogenetic footprinting technique. The majority of these contain methylatable CpG sites, suggesting that methylation may orchestrates alternative first exon usage, silencing and controlling tissue-specific expression. The heterogeneity observed may reflect epigenetic mechanisms of GR fine tuning, programmed by early life environment and events. With 78% of evolutionarily conserved alternative first exons falling into such complex CpG islands, their internal structure and epigenetic modifications are bound to be biologically important, and may be a common transcriptional control mechanism used throughout many phyla.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/nar/gkn897

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
Perceptions of epigenetics
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536
International Journal of Molecular Medicine
(2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm · Cited by 2,247
A gene hypermethylation profile of human cancer.
Esteller, M., Corn, P. G., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 2,032
DNA Modification Mechanisms and Gene Activity During Development
Holliday, R., & Pugh, J. E. (1975) · Science · doi:10.1126/science.187.4173.226 · Cited by 1,973
Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432
Aberrant CpG-island methylation has non-random and tumour-type–specific patterns
Costello, J., Frühwald, M. C., Smiraglia, D. J., Rush, L. J., Robertson, G. P., Gao, X. Y., Wright, F. A., Feramisco, J. D., Peltomäki, P., Lang, J. C., et al. (2000) · Nature Genetics · doi:10.1038/72785 · Cited by 1,359

Flagged first, then by citations

Show all 56 references

Research works printed but not linked: 5

2008, Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology, 1779, 432
McCormick, 2000, Molecular Endocrinology, 14, 506, 10.1210/me.14.4.506 · DOI
2007, The British journal of nutrition, 97, 1064, 10.1017/S000711450769196X · DOI
Esteller, 2001, Cancer Research, 61, 3225
Esteller, 1999, Cancer Research, 59, 67

Sorted by citations

Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse
Labonte, B., Yerko, V., Gross, J., Mechawar, N., Meaney, M. J., Szyf, M., & Turecki, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.034 · Cited by 345
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298
Associations Between Early Life Stress and Gene Methylation in Children
Romens, S. E., McDonald, J., Svaren, J., & Pollak, S. D. (2015) · Child Development · doi:10.1111/cdev.12270 · Cited by 299
Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed
Alt, S. R., Turner, J. D., Klok, M. D., Meijer, O. C., Lakke, E. A. J. F., DeRijk, R. H., & Muller, C. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.001 · Cited by 184
DNA methylation: conducting the orchestra from exposure to phenotype?
Leenen, F. A. D., Muller, C. P., & Turner, J. D. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0256-8 · Cited by 200
Role of the hypothalamic–pituitary–adrenal axis in developmental programming of health and disease
Xiong, F., & Zhang, L. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.11.002 · Cited by 177
Epigenetics and the Transition from Acute to Chronic Pain
Buchheit, T. E., de Ven, T. V., & Shaw, A. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01488.x · Cited by 178
Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS study
van der Knaap, L. J., Riese, H., Hudziak, J. J., Verbiest, M. M. P. J., Verhulst, F. C., Oldehinkel, A. J., & van Oort, F. V. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.22 · Cited by 165
Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more
Turner, J. D., Alt, S. R., Cao, L., Vernocchi, S., Trifonova, S. T., Battello, N., & Muller, C. P. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.037 · Cited by 152
Epidemiology of Stress and Asthma: From Constricting Communities and Fragile Families to Epigenetics
Wright, R. J. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.09.011 · Cited by 146
An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth
Drake, A. J., McPherson, R. C., Godfrey, K. M., Cooper, C. C., Lillycrop, K. A., Hanson, M. A., Meehan, R. R., Seckl, J. R., & Reynolds, R. M. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04453.x · Cited by 137
Alternative transcription and alternative splicing in cancer
Pal, S., Gupta, R., & Davuluri, R. V. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.005 · Cited by 128
Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults
Tyrka, A. R., Ridout, K. K., & Parade, S. H. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000870 · Cited by 119
Epigenetic effects of glucocorticoids
Weaver, I. C. G. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2008.12.002 · Cited by 123
S-Adenosylmethionine Inhibits the Growth of Cancer Cells by Reversing the Hypomethylation Status of c-myc and H-ras in Human Gastric Cancer and Colon Cancer
Luo, J., Li, Y., Wang, F., Zhang, W.-M., & Geng, X. (2010) · International Journal of Biological Sciences · doi:10.7150/ijbs.6.784 · Cited by 117
Shaping adult phenotypes through early life environments
Weaver, I. C. G. (2009) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20164 · Cited by 121
Early Onset Pre-Eclampsia Is Associated with Altered DNA Methylation of Cortisol-Signalling and Steroidogenic Genes in the Placenta
Hogg, K., Blair, J. D., McFadden, D. E., von Dadelszen, P., & Robinson, W. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062969 · Cited by 118
Perinatal stress and early life programming of lung structure and function
Wright, R. J. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.007 · Cited by 115
Traumatic stress and human DNA methylation: A critical review
Vinkers, C. H., Kalafateli, A. L., Rutten, B. P., Kas, M. J., Kaminsky, Z., Turner, J. D., & Boks, M. P. (2015) · Epigenomics · doi:10.2217/epi.15.11 · Cited by 112
Self-citation
Epigenetics and depressive disorders: a review of current progress and future directions
Januar, V., Saffery, R., & Ryan, J. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu273 · Cited by 99
Epigenetic regulation of the glucocorticoid receptor promoter 17in adult rats
Witzmann, S. R., Turner, J. D., Mériaux, S. B., Meijer, O. C., & Muller, C. P. (2012) · Epigenetics · doi:10.4161/epi.22363 · Cited by 90
Systemic Steroid Exposure Is Associated with Differential Methylation in Chronic Obstructive Pulmonary Disease
Wan, E. S., Qiu, W., Baccarelli, A., Carey, V. J., Bacherman, H., Rennard, S. I., Agustí, A. G. N., Anderson, W. H., Lomas, D. A., & DeMeo, D. L. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1280oc · Cited by 91
Fetal hypoxia increases vulnerability of hypoxic–ischemic brain injury in neonatal rats: Role of glucocorticoid receptors
Gonzalez‐Rodriguez, P. J., Xiong, F., Li, Y., Zhou, J., & Zhang, L. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.020 · Cited by 83
Integrating Early Life Experience, Gene Expression, Brain Development, and Emergent Phenotypes
Weaver, I. C. G. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800222-3.00011-5 · Cited by 74
Maternal Undernutrition Programs Tissue-Specific Epigenetic Changes in the Glucocorticoid Receptor in Adult Offspring
Begum, G., Davies, A., Stevens, A., Oliver, M. H., Jaquiery, A. L., Challis, J. R. G., Harding, J. E., Bloomfield, F. H., & White, A. E. (2013) · Endocrinology · doi:10.1210/en.2013-1693 · Cited by 76
The Epigenetics of Suicide: Explaining the Biological Effects of Early Life Environmental Adversity
Labonté, B., & Turecki, G. (2010) · Archives of Suicide Research · doi:10.1080/13811118.2010.524025 · Cited by 75
Dopamine D4 Receptor Gene Associated with Fairness Preference in Ultimatum Game
Zhong, S., Israel, S., Shalev, I., Xue, H., Ebstein, R. P., & Chew, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013765 · Cited by 70
Impact of Cadmium Exposure during Pregnancy on Hepatic Glucocorticoid Receptor Methylation and Expression in Rat Fetus
Castillo, P., Ibanez-Carrasco, F., Guajardo, A., Llanos, M. N., & Ronco, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044139 · Cited by 64
Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions
Cao-Lei, L., Leija, S. C., Kumsta, R., Wüst, S., Meyer, J., Turner, J. D., & Muller, C. P. (2011) · Human Genetics · doi:10.1007/s00439-011-0949-1 · Cited by 58
Sexually Dimorphic Effects of Maternal Nutrient Reduction on Expression of Genes Regulating Cortisol Metabolism in Fetal Baboon Adipose and Liver Tissues
Guo, C., Li, C., Myatt, L., Nathanielsz, P. W., & Sun, K. (2012) · Diabetes · doi:10.2337/db12-0561 · Cited by 57
Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences
de Rooij, S. R., Costello, P. M., Veenendaal, M. V. E., Lillycrop, K. A., Gluckman, P. D., Hanson, M. A., Painter, R. C., & Roseboom, T. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.010 · Cited by 52
Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells
Kay, P., Schlossmacher, G., Matthews, L. C., Sommer, P., Singh, D., White, A. E., & Ray, D. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024839 · Cited by 53
Fetal programming in dairy cows: Effect of heat stress on progeny fertility and associations with the hypothalamic-pituitary-adrenal axis functions
Huber, E., Notaro, U. S., Recce, S., Rodríguez, F. M., Ortega, H. H., Salvetti, N. R., & Rey, F. (2020) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2020.106348 · Cited by 52
The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation
Li-Tempel, T., Larra, M. F., Sandt, E., Mériaux, S. B., Schote, A. B., Schächinger, H., Muller, C. P., & Turner, J. D. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0180-y · Cited by 46
Frequent promoter hypermethylation and expression reduction of the glucocorticoid receptor gene in breast tumors
Nesset, K. A., Perri, A. M., & Mueller, C. R. (2014) · Epigenetics · doi:10.4161/epi.28484 · Cited by 46
Stress-Related Programming of Autonomic Imbalance: Role in Allergy and Asthma
Wright, R. J. (2012) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000336496 · Cited by 45
Strain‐specific vulnerability to alcohol exposure in utero via hippocampal parent‐of‐origin expression of deiodinase‐III
Sittig, L. J., Shukla, P. K., Herzing, L. B. K., & Redei, E. E. (2011) · The FASEB Journal · doi:10.1096/fj.10-179234 · Cited by 41
Prenatal famine exposure, health in later life and promoter methylation of four candidate genes
Veenendaal, M. V. E., Costello, P. M., Lillycrop, K. A., de Rooij, S. R., van der Post, J., Bossuyt, P. M., Hanson, M. A., Painter, R. C., & Roseboom, T. J. (2012) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000396 · Cited by 39
Glucocorticoid receptor gene expression and promoter CpG modifications throughout the human brain
Cao-Lei, L., Suwansirikul, S., Jutavijittum, P., Mériaux, S. B., Turner, J. D., & Muller, C. P. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.022 · Cited by 39
Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart
Xiong, F., Lin, T., Song, M., Ma, Q., Martinez, S. R., Lv, J., Mata‐Greenwood, E., Xiao, D., Xu, Z., & Zhang, L. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.003 · Cited by 38
Understanding the Psychological, Physiological, and Genetic Factors Affecting Precision Pain Medicine: A Narrative Review
Chadwick, A. L., Frazier, A., Khan, T. W., & Young, E. E. (2021) · Journal of Pain Research · doi:10.2147/jpr.s320863 · Cited by 46
Prenatal programming of the innate immune response following in utero exposure to inflammation: a sexually dimorphic process?
Hodyl, N., Stark, M., Osei-Kumah, A., & Clifton, V. (2011) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.51 · Cited by 32
Early Childhood Health and the Life Course: The State of the Science and Proposed Research Priorities
Boyce, W. T., & Hertzman, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-47143-3_4 · Cited by 34
Suicidal function of DNA methylation in age-related genome disintegration
Mazin, A. L. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.04.005 · Cited by 32
Generalized and tissue specific glucocorticoid resistance
Martins, C. S., & de Castro, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111277 · Cited by 30
Maternal High-Fat Diet Causes a Sex-Dependent Increase in AGTR2 Expression and Cardiac Dysfunction in Adult Male Rat Offspring1
Qin, X. Y., Chen, P., Li, X., Zhang, G., Patterson, A. J., & Luo, J. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.129916 · Cited by 31
Alterations of Glucocorticoid Receptor Gene Methylation in Externalizing Disorders During Childhood and Adolescence
Heinrich, A., Buchmann, A. F., Zohsel, K., Dukal, H., Frank, J., Treutlein, J., Nieratschker, V., Witt, S. H., Brandeis, D., Schmidt, M. H., et al. (2015) · Behavior Genetics · doi:10.1007/s10519-015-9721-y · Cited by 30
Where does transcription start? 5′-RACE adapted to next-generation sequencing
Leenen, F. A. D., Vernocchi, S., Hunewald, O. E., Schmitz, S., Molitor, A. M., Muller, C. P., & Turner, J. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1328 · Cited by 28
Hypermethylation of glucocorticoid receptor gene promoter results in glucocorticoid receptor gene low expression in peripheral blood mononuclear cells of patients with systemic lupus erythematosus
Chen, H., Fan, J., Shou, Q., Zhang, L., Ma, H., & Fan, Y. (2015) · Rheumatology International · doi:10.1007/s00296-015-3266-5 · Cited by 26
Epigenetic programming of diverse glucocorticoid response and inflammatory/immune-mediated disease
Chen, P., Jiang, T., Ouyang, J., Cui, Y., & Chen, Y. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.08.013 · Cited by 25
Epigenetic studies of suicidal behavior
Bani‐Fatemi, A., Howe, A. S., & Luca, V. D. (2014) · Neurocase · doi:10.1080/13554794.2013.826679 · Cited by 26
Conserved methylation of the glucocorticoid receptor gene exon 17 promoter in rats subjected to a maternal methyl‐supplemented diet
Herbeck, Y. E., Gulevich, R. G., Amelkina, O., Plyusnina, I. Z., & Oskina, I. N. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.10.004 · Cited by 23
Endothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity
Mata‐Greenwood, E., Jackson, P. N., Pearce, W. J., & Zhang, L. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0124 · Cited by 21
Elective caesarean delivery and offspring’s cognitive impairment: Implications of methylation alteration in hippocampus glucocorticoid signaling genes
Huang, K., Hu, Y., Sun, Y., Yu, Z., Liu, W. Y., Zhu, P., & Tao, F. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.11.014 · Cited by 17
Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region
Agba, O. B., Lausser, L. M., Huse, K., Bergmeier, C., Jahn, N., Groth, M., Bens, M., Sahm, A., Gall, M., Witte, O. W., et al. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00009.2017 · Cited by 17
Differential Regulation of Glucocorticoid Receptor Expression in Distinct Columns of Periaqueductal Grey in Rats with Behavioural Disability Following Nerve Injury
Mor, D., & Keay, K. A. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9962-3 · Cited by 16
Maternal Deprivation of Lewis Rat Pups Increases the Severity of Experi-mental Periodontitis in Adulthood
Breivik, T., Gundersen, Y., Murison, R., Turner, J. D., Muller, C., Gjermo, P., & Opstad, K. (2015) · Open Dentistry Journal · doi:10.2174/1874210601509010065 · Cited by 17
The Role for Epigenetic Modifications in Pain and Analgesia Response
Lessans, S., & Dorsey, S. G. (2013) · Nursing Research and Practice · doi:10.1155/2013/961493 · Cited by 18
Breed-Dependent Transcriptional Regulation of 5′-Untranslated GR (NR3C1) Exon 1 mRNA Variants in the Liver of Newborn Piglets
Zou, H., Li, R., Jia, Y., Yang, X., Ni, Y., Cong, R., Soloway, P. D., & Zhao, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040432 · Cited by 15
Epigenetic Effects of Childhood Adversity in the Brain and Suicide Risk
Dwivedi, Y. (2012) · CRC Press eBooks · doi:10.1201/b12215-19 · Cited by 14
Prenatal Hypoxia-Induced Adverse Reaction to Mild Stress is Associated with Depressive-Like Changes in the Glucocorticoid System of Rats
Vetrovoy, O. V., Stratilov, V. A., Lomert, E. V., & Tyulkova, E. I. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03837-0 · Cited by 13
Profound Effects of Dexamethasone on the Immunological State, Synthesis and Secretion Capacity of Human Testicular Peritubular Cells
Stepanov, Y. K., Speidel, J. D., Herrmann, C., Schmid, N., Behr, R., Köhn, F., Stöckl, J. B., Pickl, U., Trottmann, M., Fröhlich, T., et al. (2022) · Cells · doi:10.3390/cells11193164 · Cited by 12
Epigenetic regulation of glucocorticoid receptor and infantile spasms
Yang, G., Zou, L., Wang, J., & Ding, Y.-X. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.09.014 · Cited by 11
Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus–pituitary–adrenal axis dysfunction
Zhu, J., Zhu, F., Zhao, N., Mu, X. N., Li, P., Wang, W. T., Liu, J., & Ma, X. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23913 · Cited by 11
The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts
Taylor, K., Wheeler, R. J., Singh, N., Vosloo, D., Ray, D. W., & Sommer, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-23309-2 · Cited by 11
What is a functional locus? Understanding the genetic basis of complex phenotypic traits
Ruiz-Narváez, E. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.01.019 · Cited by 12
Prenatal Stress as a Factor of the Development of Addictive States
Stratilov, V. A., Tyulkova, E. I., & Vetrovoy, O. V. (2020) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093020060010 · Cited by 9
Toward an Understanding of the Dynamic Interdependence of Genes and Environment in the Regulation of Phenotype
Weaver, I. C. G. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_11 · Cited by 6
Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study
Vos, S., den Bergh, B. R. H. V., Martens, D. S., Bijnens, E. M., Shkedy, Z., Kindermans, H. P. J., Platzer, M., Schwab, M. G., & Nawrot, T. S. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107088 · Cited by 5
Investigation of Interactions between DNA and Nuclear Receptors: A Review of the Most Used Methods
Fattori, J., Indolfo, N. D. C., Campos, J. C. L. D. O., Videira, N. B., Bridi, A. V., Doratioto, T. R., de Assis, M. A., & Figueira, A. C. M. (2014) · Nuclear Receptor Research · doi:10.11131/2014/101090 · Cited by 5
The Epigenetics of Depression and Suicide
Labonté, B., & Turecki, G. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_4 · Cited by 4
Epigenetic Programming of Stress Responses and Trans-Generational Inheritance Through Natural Variations in Maternal Care
Weaver, I. C. G. (2010) · Advances in neurobiology · doi:10.1007/978-1-4419-7197-5_3 · Cited by 4
Antenatal Steroids and Cord Blood T-cell Glucocorticoid Receptor DNA Methylation and Exon 1 Splicing
Carpenter, J. R., Jablonski, K. A., Koncinsky, J., Varner, M. W., Gyamfi‐Bannerman, C., & Joss‐Moore, L. A. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00859-5 · Cited by 4
Epigenetics: Integrating Genetic Programs, Brain Development and Emergent Phenotypes
Weaver, I. C. G. (2014) · Cell & Developmental Biology · doi:10.4172/2168-9296.1000132 · Cited by 3
The N‐terminal transactivation domain of the glucocorticoid receptor mediates apoptosis of human small cell lung cancer cells
Singh, N., Taylor, K., Mjoli, P. B., Poolman, T. M., Ray, D. W., & Sommer, P. (2014) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22209 · Cited by 3
DNA Methylation Analysis of Steroid Hormone Receptor Genes
Camacho‐Arroyo, I., Hansberg-Pastor, V., & Rodríguez‐Dorantes, M. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0856-1_8 · Cited by 3
Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers
Bardales, J. A., Wieser, E., Kawaji, H., Murakawa, Y., & Darzacq, X. (2018) · Genes · doi:10.3390/genes9060270 · Cited by 5
Epigenetics
Turner, J. D., Kirschner, S. A., Molitor, A. M., Evdokimov, K., & Muller, C. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-097086-8.14142-x · Cited by 3
Use of alternative promoters may hide genetic effects on phenotypic traits
Ruiz-Narváez, E. (2012) · Journal of Human Genetics · doi:10.1038/jhg.2012.115 · Cited by 2
Impact of the Early-Life Environment on the Epigenome and Behavioral Development
Labonté, B., & Turecki, G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8078-5_8 · Cited by 2
Epigenetic effects of childhood abuse on the human brain
Labonté, B., & Turecki, G. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777271.040 · Cited by 2
Glucocorticoid Receptor
Stolerman, I. P., & Price, L. H. (2015) · Springer eBooks · doi:10.1007/978-3-642-36172-2_200048 · Cited by 2
Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications
Gråberg, T., Bergman, E. A., Strömmer, L., Sjöholm, L. K., Wikström, A., Winqvist, O., & Winerdal, M. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12714 · Cited by 1
Expression of Wnt5a alternative promoters A and B during cancer progression and cellular differentiation
Hsu, C. (2012) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) · Cited by 1
Social Disparities in Lung Growth and Respiratory Health
Brunst, K. J., & Wright, R. J. (2015) · Respiratory medicine · doi:10.1007/978-3-319-23675-9_8 · Cited by 1
Antenatal determinants of child lung development
Holden, K. A., Gibson, M., Sinha, I. P., & Hawcutt, D. B. (2023) · European Respiratory Society eBooks · doi:10.1183/2312508x.10016222 · Cited by 1
Correction: Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells
Kay, P., Schlossmacher, G., Matthews, L. C., Sommer, P., Singh, D., White, A. E., & Ray, D. W. (2013) · PLoS ONE · doi:10.1371/annotation/4aad3313-abac-404f-85b0-3b95aec89be4 · Cited by 1
Stress Shaping Brains: Higher Order DNA/Chromosome Mechanisms Underlying Epigenetic Programming of the Brain Transcriptome
George, S. (2011) · InTech eBooks · doi:10.5772/23106
Epigentic silencing of the glucocorticoid receptor in small cell lung cancer cells.
Houston, K. (2013)
Regional Anesthesia and Valproate Sodium for the Prevention of Chronic Post-Amputation Pain
Buchheit, T. E., Hsia, H.-L. J., Shaw, A., Buckenmaier, C. C., & de Ven, T. V. (2013) · Defense Technical Information Center (DTIC) · doi:10.21236/ada598745
The effects of a cigarette carcinogen on glucocorticoid receptor methylation.
Wheeler, R. J. (2014)
Modulation of GR transcriptional signalling by HIV-1 Vpr: insights into regulation by progestins
Grantham, N. J. (2012) · Open University of Cape Town (University of Cape Town)
Epigenetics
Labonté, B., & Turecki, G. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519502.034
The Role of Glucocorticoid Receptor in the Racial/Ethnic Disparity of Aggressive Breast Cancer
Al‐Alem, U. (2015) · Figshare
Glucocorticoid receptor promoter expression and apoptosis induction in small cell lung cancer.
Singh, N. (2013)
Research: Mediators and Moderators
Koslow, S. H., Ruiz, P., & Nemeroff, C. B. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519502.033
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
Nesset, K. A. (2012) · QSpace (Queen's University Library)
Locus specific DNA methylation in human immunological responses
Bergman, E. A. (2018) · Figshare
Specific communication between enhancers and alternative promoters mediates finer regulation of transcription initiation
Mendieta, B., & Adalberto, J. (2018)
Genetics and Epigenetics of Suicidal Behavior
Bani‐Fatemi, A. (2018) · TSpace (University of Toronto)

Authors: Turner, J. D., Pelascini, L. P. L., Macedo, J. A., & Muller, C. P.
Affiliations: Laboratoire National de Santé (LU)
Corresponding author: Muller, C. P.
ORCID: Turner, J. D.
Macedo, J. A.
Muller, C. P.
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 2008-11-12
Volume: 36
Issue: 22
Pages: 7207-7218
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/gkn897
PMC: PMC2602793
OpenAlex: W2169090691
Cited by: 104
References: 56
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 19
FWCI: 3.29
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/2.0/uk/ (vor, 2883 d)
Locations: Nucleic Acids Research (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (GRK 1389/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: glucocorticoid receptor, alternative first exons, promoter methylation, CpG islands, transcription start sites, transcription factor binding sites, phylogenetic footprinting, tissue-specific gene expression, epigenetic regulation, peripheral blood mononuclear cells
MeSH terms: Adult, Aged, Animals, Binding Sites, Cattle, Female, Humans, Male, Middle Aged, Phylogeny, Promoter Regions, Genetic, Receptors, Glucocorticoid, Transcription Factors, CpG Islands, DNA Methylation, Genomics, Transcription Initiation Site, Epigenesis, Genetic, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks