The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions
Open accessAbstract
Semen contains relatively ill-defined regulatory components that likely aid fertilization, but which could also interfere with defense against infection. Each ejaculate contains trillions of exosomes, membrane-enclosed subcellular microvesicles, which have immunosuppressive effects on cells important in the genital mucosa. Exosomes in general are believed to mediate inter-cellular communication, possibly by transferring small RNA molecules. We found that seminal exosome (SE) preparations contain a substantial amount of RNA from 20 to 100 nucleotides (nts) in length. We sequenced 20-40 and 40-100 nt fractions of SE RNA separately from six semen donors. We found various classes of small non-coding RNA, including microRNA (21.7% of the RNA in the 20-40 nt fraction) as well as abundant Y RNAs and tRNAs present in both fractions. Specific RNAs were consistently present in all donors. For example, 10 (of ∼2600 known) microRNAs constituted over 40% of mature microRNA in SE. Additionally, tRNA fragments were strongly enriched for 5'-ends of 18-19 or 30-34 nts in length; such tRNA fragments repress translation. Thus, SE could potentially deliver regulatory signals to the recipient mucosa via transfer of small RNA molecules.
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Cites
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Cited by
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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
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Metadata
- Authors
- Vojtech, L., Woo, S., Hughes, S., Levy, C., Ballweber, L., Sauteraud, R. P., Strobl, J., Westerberg, K., Gottardo, R., Tewari, M., & Hladik, F.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-16
- Volume
- 42
- Issue
- 11
- Pages
- 7290-7304
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1985207716
- Cited by
- 577
- References
- 104
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Vojtech, L., Woo, S., Hughes, S., Levy, C., Ballweber, L., Sauteraud, R. P., Strobl, J., Westerberg, K., Gottardo, R., Tewari, M., & Hladik, F. (2014). Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Research. https://doi.org/10.1093/nar/gku347
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