Cited by 765Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

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Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

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Enuka, Yehoshua, Lauriola, Mattia, Feldman, Morris E., Sas-Chen, Aldema, Ulitsky, Igor, Yarden, Yosef·2016·Nucleic Acids Research

DOI 10.1093/nar/gkv1367PMC PMC4756822

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Abstract

Circular RNAs (circRNAs) are widespread circles of non-coding RNAs with largely unknown function. Because stimulation of mammary cells with the epidermal growth factor (EGF) leads to dynamic changes in the abundance of coding and non-coding RNA molecules, and culminates in the acquisition of a robust migratory phenotype, this cellular model might disclose functions of circRNAs. Here we show that circRNAs of EGF-stimulated mammary cells are stably expressed, while mRNAs and microRNAs change within minutes. In general, the circRNAs we detected are relatively long-lived and weakly expressed. Interestingly, they are almost ubiquitously co-expressed with the corresponding linear transcripts, and the respective, shared promoter regions are more active compared to genes producing linear isoforms with no detectable circRNAs. These findings imply that altered abundance of circRNAs, unlike changes in the levels of other RNAs, might not play critical roles in signaling cascades and downstream transcriptional networks that rapidly commit cells to specific outcomes.

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Authors: Enuka, Y., Lauriola, M., Feldman, M. E., Sas-Chen, A., Ulitsky, I., & Yarden, Y.
Affiliations: Weizmann Institute of Science (IL)
Corresponding author: Yarden, Yosef
ORCID: Enuka, Yehoshua
Lauriola, Mattia
Ulitsky, Igor
Yarden, Yosef
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 2015-12-10
Volume: 44
Issue: 3
Pages: 1370-1383
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/gkv1367
PMC: PMC4756822
OpenAlex: W2285247593
Cited by: 757
References: 64
Citations by year: 2026: 66 · 2025: 91 · 2024: 100 · 2023: 105 · 2022: 93 · 2021: 107 · 2020: 68 · 2019: 57 · 2018: 33 · 2017: 26 · 2016: 9
FWCI: 9.85
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (vor, 340 d)
Locations: Nucleic Acids Research (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by-nc)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, epidermal growth factor, mammary epithelial cells, RNA stability, non-coding RNA, microRNA, cell migration, growth factor signaling
MeSH terms: RNA, Circular, Breast, Cell Line, Epidermal Growth Factor, Epithelial Cells, Humans, RNA, RNA, Messenger, Gene Expression, Transforming Growth Factor alpha, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, RNA Stability, MicroRNAs, Heparin-binding EGF-like Growth Factor

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Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

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