The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
Open accessAbstract
Abstract Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed to Asian ZIKV C , African ZIKV M , and dengue virus (DENV). In contrast to the robust global transcriptome changes induced by DENV, ZIKV has a more selective and larger impact on expression of genes involved in DNA replication and repair. While overall expression profiles are similar, ZIKV C , but not ZIKV M , induces upregulation of viral response genes and TP53. P53 inhibitors can block the apoptosis induced by both ZIKV C and ZIKV M in hNPCs, with higher potency against ZIKV C -induced apoptosis. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. These datasets will help to investigate ZIKV-host interactions and identify neurovirulence determinants of ZIKV.
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Cites
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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
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Differential analysis of gene regulation at transcript resolution with RNA-seq
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Zika Virus Associated with Microcephaly
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Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
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Self-citationA Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
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Zika virus impairs growth in human neurospheres and brain organoids
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Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities
Driggers, R. W., Ho, C.-Y., Korhonen, E. M., Kuivanen, S., Jääskeläinen, A. J., Smura, T., Rosenberg, A., Hill, D. A., DeBiasi, R. L., Vezina, G., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1601824 · Cited by 831
Synaptic dysregulation in a human iPS cell model of mental disorders
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Self-citationZika virus and microcephaly: why is this situation a PHEIC?
Heymann, D. L., Hodgson, A., Sall, A. A., Freedman, D. O., Staples, J. E., Althabe, F., Baruah, K., Mahmud, G., Kandun, N., Vasconcelos, P. F. C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00320-2 · Cited by 415
Cited by
Azevedo, R. S. S., de Sousa, J. R., Araujo, M. T. F., Martins Filho, A. J., de Alcantara, B. N., Araujo, F. M. C., Queiroz, M. G. L., Cruz, A. C. R., Vasconcelos, B. H. B., Chiang, J. O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17765-5 · Cited by 3,478
Brain organoids: advances, applications and challenges
Qian, X., Song, H., & Ming, G.-L. (2019) · Development · doi:10.1242/dev.166074 · Cited by 724
Self-citationA single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Yuan, L., Huang, X.-Y., Liu, Z.-Y., Zhang, F., Zhu, X.-L., Yu, J.-Y., Ji, X., Xu, Y.-P., Li, G., Li, C., et al. (2017) · Science · doi:10.1126/science.aam7120 · Cited by 473
Self-citationWatanabe, M., Buth, J. E., Vishlaghi, N., de la Torre-Ubieta, L., Taxidis, J., Khakh, B. S., Coppola, G., Pearson, C. A., Yamauchi, K., Gong, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.047 · Cited by 401
Metadata
- Authors
- Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W.-K., Yoon, K.-J., Shan, C., Huang, L., Qin, Z., Christian, K. M., Shi, P.-Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G.-L., & Jin, P.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-08-31
- Volume
- 44
- Issue
- 18
- Pages
- 8610-8620
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2513559175
- Cited by
- 171
- References
- 11
- FWCI
- 26.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W.-K., Yoon, K.-J., Shan, C., Huang, L., . . . Jin, P. (2016). Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Research. https://doi.org/10.1093/nar/gkw765
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