The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Rapid generation of inducible mouse mutants
Open accessAbstract
We have generated an optimized inducible recombination system for conditional gene targeting based on a Cre recombinase-steroid receptor fusion. This configuration allows efficient Cre-mediated recombination in most organs of the mouse upon induction, without detectable background activity. An ES cell line, was established that carries the inducible recombinase and a loxP-flanked lacZ reporter gene. Out of this line, completely ES cell-derived mice were efficiently produced through tetraploid blastocyst complementation, without the requirement of mouse breeding. Our findings provide a new concept allowing the generation of inducible mouse mutants within 6 months, as compared to 14 months using the current protocol.
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Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
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Metadata
- Authors
- Seibler, J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-15
- Volume
- 31
- Issue
- 4
- Pages
- 12e-12
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2157182132
- Cited by
- 305
- References
- 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Seibler, J. (2003). Rapid generation of inducible mouse mutants. Nucleic Acids Research. https://doi.org/10.1093/nar/gng012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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