The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury
Open accessAbstract
A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with 2019-nCoV infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-nCoV, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-nCoV-infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-α2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-γ, IL-1α, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of 2019-nCoV infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-nCoV infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Cited by
Yang, Y., Shen, C., Li, J., Yuan, J., Wei, J., Huang, F., Wang, F., Li, G., Li, Y., Xing, L., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.04.027 · Cited by 872
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Self-citationComparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., et al. (2020) · Science · doi:10.1126/science.abe9403 · Cited by 747
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Metadata
- Authors
- Liu, Y., Zhang, C., Huang, F., Yang, Y., Wang, F., Yuan, J., Zhang, Z., Qin, Y., Li, X., Zhao, D., Li, S., Tan, S., Wang, Z., Li, J., Shen, C., Li, J., Peng, L., Wu, W., Cao, M., Xing, L., Xu, Z., Chen, L., Zhou, C., Liu, W. J., Liu, L., & Jiang, C.
- Venue
- National Science Review
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-09
- Volume
- 7
- Issue
- 6
- Pages
- 1003-1011
- ISSN
- 2053-714X (ISSN-L)
- 2095-5138
- OpenAlex
- W3015549965
- Cited by
- 269
- References
- 44
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, Y., Zhang, C., Huang, F., Yang, Y., Wang, F., Yuan, J., Zhang, Z., Qin, Y., Li, X., Zhao, D., Li, S., Tan, S., Wang, Z., Li, J., Shen, C., Li, J., Peng, L., Wu, W., Cao, M., . . . Jiang, C. (2020). Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury. National Science Review. https://doi.org/10.1093/nsr/nwaa037
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