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Effect of Prenatal Exposure to Waterpipe Tobacco Smoke on Learning and Memory of Adult Offspring Rats

Al-Sawalha, Nour, Alzoubi, Karem, Khabour, Omar, Alyacoub, Weam, Almahmmod, Yehya, Eissenberg, Thomas·2018·Nicotine & Tobacco Research
DOI 10.1093/ntr/ntx142
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Abstract

Introduction Waterpipe tobacco smoking has increased in prevalence worldwide, including among pregnant women. In this study, we investigated the effect of prenatal maternal waterpipe tobacco smoke (WTS) exposure during different stages of pregnancy on learning and memory of adult offspring rats. Methods Pregnant rats received either fresh air or mainstream WTS (2 hours daily) during early, mid, late, or whole gestational period. Male offspring rats were followed through 20 weeks. Outcomes included (1) spatial learning and memory using the radial arm water maze (RAWM), (2) levels of brain derived neurotrophic factor (BDNF) in the hippocampus, and (3) oxidative stress biomarkers (superoxide dismutase, catalase, glutathione peroxidase and thiobarbituric acid reactive substances). Results Relative to offspring whose mothers were exposed to fresh air, prenatal exposure to WTS at any stage of pregnancy resulted in short- and long-term memory impairment in adult offspring rats (p Conclusion Prenatal maternal WTS exposure can impair the memory of adult male offspring. These results support development of interventions that target pregnant women who smoke waterpipe during pregnancy. Implications We examined for the first time the effect of prenatal waterpipe tobacco smoke exposure on learning and memory of offspring. The results showed that in utero exposure to waterpipe tobacco smoke was associated with impaired memory and decreased brain derived neurotrophic factor in hippocampus of…

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Metadata

Authors
Al-Sawalha, N., Alzoubi, K., Khabour, O., Alyacoub, W., Almahmmod, Y., & Eissenberg, T.
Affiliations
  • Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
  • Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
  • Department of Psychology (Health Program) and Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, VA
Venue
Nicotine & Tobacco Research
Publisher
Oxford University Press (OUP)
Published
2017-06-20
Volume
20
Issue
4
Pages
508-514
ISSN
  • 1462-2203
  • 1469-994X
DOI
10.1093/ntr/ntx142
Cited by
28
References
3
Language
en
Funders
  • Jordan University of Science and Technology (227/2015)
  • National Institute on Drug Abuse
  • National Institutes of Health (P50DA036105)
  • U.S. Food and Drug Administration

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CoChat. (2026). Citation check: Effect of Prenatal Exposure to Waterpipe Tobacco Smoke on Learning and Memory of Adult Offspring Rats. https://app.cochat.ai/papers/10.1093/ntr/ntx142
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Al-Sawalha, N., Alzoubi, K., Khabour, O., Alyacoub, W., Almahmmod, Y., & Eissenberg, T. (2018). Effect of Prenatal Exposure to Waterpipe Tobacco Smoke on Learning and Memory of Adult Offspring Rats. Nicotine & Tobacco Research. https://doi.org/10.1093/ntr/ntx142