Spatial memory, recognition memory, and the hippocampus

Broadbent, Nicola J.; Squire, Larry R.; Clark, Robert E.

doi:10.1073/pnas.0406344101

Cited by 986Memory and Neural MechanismsMemory Processes and InfluencesSpatial Cognition and Navigation

Spatial memory, recognition memory, and the hippocampus

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Broadbent, Nicola J., Squire, Larry R., Clark, Robert E.·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0406344101PMC PMC521976

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Abstract

There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30-50% total volume, and as lesion size increased from 50% to approximately 100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50-75% of total hippocampal volume and was impaired only after larger lesions that encompassed 75-100% of hippocampal volume. Last, ventral hippocampal lesions that encompassed approximately 50% of total hippocampal volume impaired spatial memory but did not affect object recognition memory. These findings show that the hippocampus is important for both spatial memory and recognition memory. However, spatial memory performance requires more hippocampal tissue than does recognition memory.

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Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory.
“Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory (Ainge et al., 2006; Broadbent et al., 2010; Broadbent et al., 2004; Clark et al., 2000), whereas the majority of the studies employing hippocampal lesions in rats failed to report an influence in the NOP test (Albasser et al., 2012; Albasser et al., 2010; Barker and Warburton”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2004
Severe, but not partial, lesions of the hippocampus influenced NOP memory.
“Lesion extent of the hippocampus has been discussed, in that severe, but not partial, lesions influenced NOP memory (Broadbent et al., 2004).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2004

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Authors: Broadbent, N. J., Squire, L. R., & Clark, R. E.
Affiliations: University of California San Diego (US)
Corresponding author: Clark, Robert E.
ORCID: Squire, Larry R.
Clark, Robert E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2004-09-27
Volume: 101
Issue: 40
Pages: 14515-14520
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0406344101
PMC: PMC521976
OpenAlex: W2038813826
Cited by: 985
References: 37
Citations by year: 2026: 25 · 2025: 26 · 2024: 35 · 2023: 40 · 2022: 59 · 2021: 51 · 2020: 55 · 2019: 53 · 2018: 56 · 2017: 57 · 2016: 51 · 2015: 51 · 2014: 52 · 2013: 48 · 2012: 63
FWCI: 14.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
U.S. Department of Veterans Affairs
James S. McDonnell Foundation
National Alliance for Research on Schizophrenia and Depression
National Institute on Aging (P50AG005131, P50-AG05131)
National Institute of Mental Health (P50 AG05131, AG05131)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
Keywords: spatial memory, recognition memory, hippocampus, hippocampal lesions, lesion size, dorsal hippocampus, ventral hippocampus, object recognition, rats
MeSH terms: Animals, Hippocampus, Male, Memory, Spatial Behavior, Rats, Long-Evans, Recognition, Psychology, Rats

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Spatial memory, recognition memory, and the hippocampus

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