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The Effect of Different Types of Olive Oil on Glucose Control and Insulin Sensitivity: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of 51 Randomized Controlled Trials

Takhttavous, Alireza, Rostampour, Kimia, Gerami, Shirin, Mohammadi-Sartang, Mohsen·2026·Nutrition Reviews
DOI 10.1093/nutrit/nuaf099
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Abstract

Background: Olive oil as food is composed mainly of fatty acids and bioactive compounds with diverse and attractive biological activities that have an inverse relationship with insulin resistance and diabetes-related factors. However, the results of available clinical trials are inconsistent. Therefore, we summarized 51 randomized controlled trials (RCTs) and evaluated the association of olive oil intervention with glycemic control in adults. Methods: A comprehensive literature search of the PubMed, Scopus, and ISI Web of Sciences databases was performed to identify RCTs investigating the effect of different olive oil types on any glycemic profile component. Quantitative data were synthesized using either a fixed or random-effects model, with a weighted mean difference (WMD) and 95% CI for analysis. Results: In the primary search, 2705 articles were found, of which 115 were assessed in full text, and 51 trials (n = 4334 participants) were included in the meta-analysis. We found the consumption of olive oil was not associated with statistically significant changes in blood glucose (WMD = –0.04 mg dL–1; 95% CI, –0.1 to 0.02; P = .18; I2 = 27.05%), insulin (WMD = –0.3 µIU mL–1; 95% CI, –0.99 to 0.38; P = .39; I2 = 91.49%), hemoglobin A1c (HbA1c) (WMD = 0.02%, 95% CI, –0.01 to 0.06; P = .21; I2 = 0%) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (WMD = –0.09; 95% CI, –0.25 to 0.06; P = .26; I2 = 73.13%). The nonlinear dose-response analysis showed a significant association between the olive dose and HOMA-IR (P = .024 for nonlinearity). Also, the duration of olive oil intervention showed a significant nonlinear relationship with HOMA-IR (P = .025 for nonlinearity), insulin (P = .002 for nonlinearity), and HbA1c (P = .048 for nonlinearity) in dose-response analysis. Conclusions: Our comprehensive review and meta-analysis of 51 RCTs indicate that olive oil consumption by adults does not significantly affect overall glycemic control. However, a daily dose of 25-50 g significantly improves the HOMA-IR parameter, suggesting a potential benefit for diabetes management. These findings highlight the need for further research to fully understand the practical implications of olive oil consumption in diabetes care. Systematic Review Registration: PROSPERO registration No. CRD42023459523

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  1. Waterman, 2007, Active components and clinical applications of olive oil, Altern Med Rev, 12, 331
  2. Ditano-Vázquez, 2019, The fluid aspect of the Mediterranean diet in the prevention and management of cardiovascular disease and diabetes: the role of polyphenol content in moderate consumption of wine and olive oil, Nutrients, 11, 2833, 10.3390/nu11112833 · DOI
  3. Vissers, 2004, Bioavailability and antioxidant effects of olive oil phenols in humans: a review, Eur J Clin Nutr, 58, 955, 10.1038/sj.ejcn.1601917 · DOI
  4. Vitale, 2018, Impact of a Mediterranean dietary pattern and its components on cardiovascular risk factors, glucose control, and body weight in people with type 2 diabetes: a real-life study, Nutrients, 10, 1067, 10.3390/nu10081067 · DOI
  5. Schwingshackl, 2018, A network meta-analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus, Eur J Epidemiol, 33, 157, 10.1007/s10654-017-0352-x · DOI · Paper page
  6. Violi, 2015, Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects, Nutr Diabetes, 5, e172, 10.1038/nutd.2015.23 · DOI
  7. Yubero-Serrano, 2019, Extra virgin olive oil: more than a healthy fat, Eur J Clin Nutr, 72, 8, 10.1038/s41430-018-0304-x · DOI
  8. Jurado-Ruiz, 2017, An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat “Western type” diet in mice, Mol Nutr Food Res, 61, 1770034, 10.1002/mnfr.201770034 · DOI
  9. Cancelas, 2006, Effects of an olive oil-enriched diet on glucagon-like peptide 1 release and intestinal content, plasma insulin concentration, glucose tolerance and pancreatic insulin content in an animal model of type 2 diabetes, Horm Metab Res, 38, 98, 10.1055/s-2006-925126 · DOI
  10. Jurado-Ruiz, 2019, Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice, Sci Rep, 9, 11311, 10.1038/s41598-019-47904-z · DOI
  11. Schwingshackl, 2017, Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials, Nutr Diabetes, 7, e262, 10.1038/nutd.2017.12 · DOI
  12. Morvaridzadeh, 2024, Effect of extra virgin olive oil on anthropometric indices, inflammatory and cardiometabolic markers: a systematic review and meta-analysis of randomized clinical trials, J Nutr, 154, 95, 10.1016/j.tjnut.2023.10.028 · DOI · Paper page
  13. Dehghani, 2021, Effect of extra virgin olive oil consumption on glycemic control: a systematic review and meta-analysis, Nutr Metab Cardiovasc Dis, 31, 1953, 10.1016/j.numecd.2021.02.017 · DOI
  14. Schwingshackl, 2017, Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials, Nutr Diabetes, 7, e262, 10.1038/nutd.2017.12 · DOI
  15. Dehghani, 2021, Effect of extra virgin olive oil consumption on glycemic control: a systematic review and meta-analysis, Nutr Metab Cardiovasc Dis, 31, 1953, 10.1016/j.numecd.2021.02.017 · DOI
  16. Morvaridzadeh, 2024, Effect of extra virgin olive oil on anthropometric indices, inflammatory and cardiometabolic markers: a systematic review and meta-analysis of randomized clinical trials, J Nutr, 154, 95, 10.1016/j.tjnut.2023.10.028 · DOI · Paper page
  17. Higgins, 2011, Cochrane Handbook for Systematic Reviews of Interventions
  18. Guyatt, 2011, GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables, J Clin Epidemiol, 64, 383, 10.1016/j.jclinepi.2010.04.026 · DOI · Paper page
  19. Balshem, 2011, GRADE guidelines: 3. Rating the quality of evidence, J Clin Epidemiol, 64, 401, 10.1016/j.jclinepi.2010.07.015 · DOI · Paper page
  20. Guyatt, 2011, GRADE guidelines: 9. Rating up the quality of evidence, J Clin Epidemiol, 64, 1311, 10.1016/j.jclinepi.2011.06.004 · DOI · Paper page
  21. Higgins, 2008, Cochrane Handbook for Systematic Reviews of Interventions, 10.1002/9780470712184 · DOI · Paper page
  22. Hozo, 2005, Estimating the mean and variance from the median, range, and the size of a sample, BMC Med Res Methodol, 5, 13, 10.1186/1471-2288-5-13 · DOI · Paper page
  23. Duval, 2000, Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x · DOI · Paper page
  24. Tuccinardi, 2022, An extra virgin olive oil-enriched chocolate spread positively modulates insulin-resistance markers compared with a palm oil-enriched one in healthy young adults: a double-blind, cross-over, randomised controlled trial, Diabetes Metab Res Rev, 38, e3492, 10.1002/dmrr.3492 · DOI
  25. Mohammadi Hosseinabadi, 2022, Effects of diets rich in ghee or olive oil on cardiometabolic risk factors in healthy adults: a 2-period, crossover, randomized trial, Br J Nutr, 128, 1720, 10.1017/S0007114521004645 · DOI
  26. Santos, 2020, Traditional Brazilian diet and olive oil reduce cardiometabolic risk factors in severely obese individuals: a randomized trial, Nutrients, 12, 1413, 10.3390/nu12051413 · DOI
  27. Rezaei, 2019, Olive oil lessened fatty liver severity independent of cardiometabolic correction in patients with non-alcoholic fatty liver disease: a randomized clinical trial, Nutrition, 57, 154, 10.1016/j.nut.2018.02.021 · DOI
  28. Pintó, 2019, A Mediterranean diet rich in extra-virgin olive oil is associated with a reduced prevalence of nonalcoholic fatty liver disease in older individuals at high cardiovascular risk, J Nutr, 149, 1920, 10.1093/jn/nxz147 · DOI
  29. Sun, 2018, Effects of palm olein and olive oil on serum lipids in a Chinese population: a randomized, double-blind, cross-over trial, Asia Pac J Clin Nutr, 27, 572, 10.6133/apjcn.032017.12 · DOI
  30. Khaw, 2018, Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women, BMJ Open, 8, e020167, 10.1136/bmjopen-2017-020167 · DOI
  31. Oliveras-López, 2013, Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans, Arch Gerontol Geriatr, 57, 234, 10.1016/j.archger.2013.04.002 · DOI
  32. Hernáez, 2017, Mediterranean diet improves high-density lipoprotein function in high-cardiovascular-risk individuals: a randomized controlled trial, Circulation, 135, 633, 10.1161/CIRCULATIONAHA.116.023712 · DOI
  33. Morillas-Ruiz, 2014, The type of fat ingested at breakfast influences the plasma lipid profile of postmenopausal women, BioMed Res Int, 2014, 815915, 10.1155/2014/815915 · DOI
  34. Connor, 1993, The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control, Ann N Y Acad Sci, 683, 337, 10.1111/j.1749-6632.1993.tb35725.x · DOI
  35. Galvão Cândido, 2018, Consumption of extra virgin olive oil improves body composition and blood pressure in women with excess body fat: a randomized, double-blinded, placebo-controlled clinical trial, Eur J Nutr, 57, 2445, 10.1007/s00394-017-1517-9 · DOI
  36. Estruch, 2006, Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial, Ann Intern Med, 145, 1, 10.7326/0003-4819-145-1-200607040-00004 · DOI · Paper page
  37. Ferrara, 2000, Olive oil and reduced need for antihypertensive medications, Arch Intern Med, 160, 837, 10.1001/archinte.160.6.837 · DOI
  38. Jensen, 1989, Partial normalization by dietary cod-liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria, N Engl J Med, 321, 1572, 10.1056/nejm198912073212304 · DOI
  39. González-Rámila, 2022, Effect of olive pomace oil on cardiovascular health and associated pathologies, Nutrients, 14, 10.3390/nu14193927 · DOI
  40. Taylor, 2006, Conjugated linoleic acid impairs endothelial function, Arterioscler Thromb Vasc Biol, 26, 307, 10.1161/01.ATV.0000199679.40501.ac · DOI
  41. Gammelmark, 2012, Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects, Nutr Res, 32, 15, 10.1016/j.nutres.2011.12.007 · DOI
  42. Sirtori, 1986, Controlled evaluation of fat intake in the Mediterranean diet: comparative activities of olive oil and corn oil on plasma lipids and platelets in high-risk patients, Am J Clin Nutr, 44, 635, 10.1093/ajcn/44.5.635 · DOI
  43. Atefi, 2018, The effects of canola and olive oils on insulin resistance, inflammation and oxidative stress in women with type 2 diabetes: a randomized and controlled trial, J Diabetes Metab Disord, 17, 85, 10.1007/s40200-018-0343-9 · DOI
  44. Kontogianni, 2013, Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults, Metab Clin Exp, 62, 686, 10.1016/j.metabol.2012.11.007 · DOI
  45. Fernández-Real, 2012, A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk, J Clin Endocrinol Metab, 97, 3792, 10.1210/jc.2012-2221 · DOI
  46. Tholstrup, 2011, Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals, Am J Clin Nutr, 94, 1426, 10.3945/ajcn.111.018846 · DOI
  47. Damasceno, 2011, Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers, Nutr Metab Cardiovasc Dis, 21(suppl 1), S14, 10.1016/j.numecd.2010.12.006 · DOI
  48. St-Onge, 2008, Medium chain triglyceride oil consumption as part of a weight loss diet does not lead to an adverse metabolic profile when compared to olive oil, J Am Coll Nutr, 27, 547, 10.1080/07315724.2008.10719737 · DOI
  49. Nydahl, 1995, Similar effects of rapeseed oil (canola oil) and olive oil in a lipid-lowering diet for patients with hyperlipoproteinemia, J Am Coll Nutr, 14, 643, 10.1080/07315724.1995.10718554 · DOI
  50. Engel, 2015, Butter increased total and LDL cholesterol compared with olive oil but resulted in higher HDL cholesterol compared with a habitual diet, Am J Clin Nutr, 102, 309, 10.3945/ajcn.115.112227 · DOI
  51. Lasa, 2014, Comparative effect of two Mediterranean diets versus a low-fat diet on glycaemic control in individuals with type 2 diabetes, Eur J Clin Nutr, 68, 767, 10.1038/ejcn.2014.1 · DOI
  52. McGrath, 1996, Effect of dietary fish oil supplementation on peroxidation of serum lipids in patients with non-insulin dependent diabetes mellitus, Atherosclerosis, 121, 275, 10.1016/0021-9150(95)05741-2 · DOI
  53. Mazza, 2018, Effect of the replacement of dietary vegetable oils with a low dose of extra virgin olive oil in the Mediterranean diet on cognitive functions in the elderly, J Transl Med, 16, 10, 10.1186/s12967-018-1386-x · DOI
  54. Rozati, 2015, Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial, Nutr Metab, 12, 28, 10.1186/s12986-015-0022-5 · DOI
  55. Hendra, 1990, Effects of fish oil supplements in NIDDM subjects. Controlled study, Diabetes Care, 13, 821, 10.2337/diacare.13.8.821 · DOI
  56. Brynes, 2000, Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes, Am J Clin Nutr, 72, 1111, 10.1093/ajcn/72.5.1111 · DOI
  57. Lobraico, 2015, Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial, BMJ Open Diabetes Res Care, 3, e000107, 10.1136/bmjdrc-2015-000107 · DOI
  58. Prater, 2022, Blood lipid responses to diets enriched with cottonseed oil compared with olive oil in adults with high cholesterol in a randomized trial, J Nutr, 152, 2060, 10.1093/jn/nxac099 · DOI
  59. Dos Santos, 2022, Effect of pecan nuts and extra-virgin olive oil on glycemic profile and nontraditional anthropometric indexes in patients with coronary artery disease: a randomized clinical trial, Eur J Clin Nutr, 76, 827, 10.1038/s41430-021-01045-7 · DOI
  60. Yahay, 2021, The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial, Lipids Health Dis, 20, 7, 10.1186/s12944-021-01433-9 · DOI
  61. Wijayanthie, 2019, Effects of extra virgin olive oil versus rice bran oil on glycemic control in patients with type-2 diabetes mellitus, Int J Appl Pharm, 11, 56, 10.22159/ijap.2019.v11s6.33540 · DOI
  62. Cheng, 2019, A comparative study of the effects of palm olein, cocoa butter and extra virgin olive oil on lipid profile, including low-density lipoprotein subfractions in young healthy Chinese people, Int J Food Sci Nutr, 70, 355, 10.1080/09637486.2018.1504009 · DOI
  63. Nigam, 2014, Effect of a 6-month intervention with cooking oils containing a high concentration of monounsaturated fatty acids (olive and canola oils) compared with control oil in male Asian Indians with nonalcoholic fatty liver disease, Diabetes Technol Ther, 16, 255, 10.1089/dia.2013.0178 · DOI
  64. Sirtori, 1997, N-3 fatty acids do not lead to an increased diabetic risk in patients with hyperlipidemia and abnormal glucose tolerance. Italian Fish Oil Multicenter Study, Am J Clin Nutr, 65, 1874, 10.1093/ajcn/65.6.1874 · DOI
  65. Patti, 1999, Long-term effects of fish oil on lipoprotein subfractions and low density lipoprotein size in non-insulin-dependent diabetic patients with hypertriglyceridemia, Atherosclerosis, 146, 361, 10.1016/S0021-9150(99)00149-5 · DOI
  66. Venturini, 2015, Effects of extra virgin olive oil and fish oil on lipid profile and oxidative stress in patients with metabolic syndrome, Nutrition, 31, 834, 10.1016/j.nut.2014.12.016 · DOI
  67. Annuzzi, 1991, A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients, Atherosclerosis, 87, 65, 10.1016/0021-9150(91)90233-s · DOI
  68. Wong, 2010, Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with type 2 diabetes mellitus, Diabet Med, 27, 54, 10.1111/j.1464-5491.2009.02869.x · DOI
  69. Prater, 2023, Metabolic responses to 8 weeks of consuming cottonseed oil versus olive oil in adults with dyslipidaemia: a randomised trial, J Hum Nutr Diet, 36, 1079, 10.1111/jhn.13085 · DOI
  70. Rossing, 1996, Fish oil in diabetic nephropathy, Diabetes Care, 19, 1214, 10.2337/diacare.19.11.1214 · DOI
  71. Stirban, 2010, Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus, Am J Clin Nutr, 91, 808, 10.3945/ajcn.2009.28374 · DOI
  72. Alkhatib, 2018, Olive oil nutraceuticals in the prevention and management of diabetes: from molecules to lifestyle, Int J Mol Sci, 19, 2024, 10.3390/ijms19072024 · DOI
  73. Santangelo, 2016, Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin, J Endocrinol Invest, 39, 1295, 10.1007/s40618-016-0506-9 · DOI · Paper page
  74. Narita, 2009, Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas α-amylase isozymes I and II, J Agric Food Chem, 57, 9218, 10.1021/jf9017383 · DOI
  75. Silva, 2016, Oleanolic, ursolic, and betulinic acids as food supplements or pharmaceutical agents for type 2 diabetes: promise or illusion?, J Agric Food Chem, 64, 2991, 10.1021/acs.jafc.5b06021 · DOI
  76. Quintero-Flórez, 2015, The fatty acid composition of virgin olive oil from different cultivars is determinant for foam cell formation by macrophages, J Agric Food Chem, 63, 6731, 10.1021/acs.jafc.5b01626 · DOI
  77. Hidalgo, 2018, Changes in gut microbiota linked to a reduction in systolic blood pressure in spontaneously hypertensive rats fed an extra virgin olive oil-enriched diet, Plant Foods Hum Nutr, 73, 1, 10.1007/s11130-017-0650-1 · DOI
  78. Konstantinidou, 2009, Characterization of human gene expression changes after olive oil ingestion: an exploratory approach, Fol Biol (Praha), 55, 85, 10.14712/fb2009055030085 · DOI
  79. Khymenets, 2009, Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study, Omics, 13, 7, 10.1089/omi.2008.0079 · DOI · Paper page
  80. Riolo, 2022, Olive oil in the mediterranean diet and its biochemical and molecular effects on cardiovascular health through an analysis of genetics and epigenetics, Int J Mol Sci, 23, 10.3390/ijms232416002 · DOI
  81. Castañer, 2012, Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans, Am J Clin Nutr, 95, 1238, 10.3945/ajcn.111.029207 · DOI
  82. Castañer, 2013, In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk patients: a randomized controlled trial, Am J Clin Nutr, 98, 845, 10.3945/ajcn.113.060582 · DOI
  83. Folsom, 2003, Prediction of coronary heart disease in middle-aged adults with diabetes, Diabetes Care, 26, 2777, 10.2337/diacare.26.10.2777 · DOI
  84. Piroddi, 2017, Nutrigenomics of extra-virgin olive oil: a review, Biofactors, 43, 17, 10.1002/biof.1318 · DOI
  85. Gentile, 2017, Soft-MS and computational mapping of oleuropein, Int J Mol Sci, 18, 992, 10.3390/ijms18050992 · DOI

Metadata

Authors
Takhttavous, A., Rostampour, K., Gerami, S., & Mohammadi-Sartang, M.
Venue
Nutrition Reviews
Publisher
Oxford University Press (OUP)
Published
2025-09-15
Volume
84
Issue
2
Pages
345-365
ISSN
  • 0029-6643
  • 1753-4887
DOI
10.1093/nutrit/nuaf099
Cited by
1
References
8
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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