Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
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Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet.
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Previous assays have shown that triterpenes characteristic of OPO (OA and MA) modulate endothelial cell inflammation and suppress the production of inflammatory mediators such as TNFα and nuclear transcription factor kappa B (NF-κB) in in vivo and in vitro assays.
“Previous assays have shown that triterpenes characteristic of OPO (OA and MA) modulate endothelial cell inflammation and suppress the production of inflammatory mediators such as TNFα and nuclear transcription factor kappa B (NF-κB) in in vivo and in vitro assays [7, 8, 34, 39].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [8]
The Introduction identifies oleanolic and maslinic acids as triterpenes in pomace olive oil. Results §3.3 reports that a triterpenic-acid-enriched pomace olive oil diet attenuated Tnfα gene expression in adipose tissue and liver of obese mice. The paper does not report suppression of NF-κB or show that these acids suppress inflammatory mediators in endothelial cells in both in vivo and in vitro assays. (LLM, conf=0.87)
Experimental — accuracy not yet measuredNumerous in vitro and preclinical studies with minor components of OPO have shown promising results on different cardiometabolic traits.
“Numerous in vitro and preclinical studies have been conducted with one or more of these so-called minor components of OPO, offering promising results on different cardiometabolic traits [7–9].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [8]
These trials were carried out in lipopolysaccharide challenged endothelial cells or in animal models of different pathologies such as hypertension or obesity, involving inflammatory processes.
“These trials were carried out in lipopolysaccharide challenged endothelial cells [39] or in animal models of different pathologies such as hypertension [7] or obesity [8], involving inflammatory processes.”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [8]
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González-Rámila, S., Sarriá, B., Seguido, M. A., García-Cordero, J., Mateos, R., & Bravo, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03001-y · Cited by 24 · see citing works
- Authors
- Claro-Cala, C. M., Quintela, J. C., Pérez-Montero, M., Miñano, J., Alvarez de Sotomayor, M., Herrera, M. D., & Rodríguez-Rodríguez, R.
- Affiliations
- Department of Pharmacology, Pediatric and Radiology, Faculty of Medicine, University of Sevilla, E-41009 Sevilla, Spain
- Natac Biotech S.L., Electrónica 7, 28923 Alcorcón, Madrid, Spain
- Universitat Internacional de Catalunya (ES)
- Universidad de Sevilla (ES)
- Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain
- Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-01-26
- Volume
- 12
- Issue
- 2
- Pages
- 323
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7071211
- OpenAlex
- W3001192597
- Cited by
- 33
- References
- 46
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 11 · 2021: 5 · 2020: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Hispana (acceptedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc-nd)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Funders
- Ministerio de Ciencia, Innovación y Universidades (SAF2017-82813-C3-3-R, PCI2018-092997 /AEI)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- olive pomace oil, triterpenic acids, oleanolic acid, maslinic acid, diet-induced obesity, vascular function, glucose tolerance, insulin resistance, adipose tissue inflammation, functional foods, Mediterranean diet, olive oil by-products
- MeSH terms
- Olive Oil, Animals, Aorta, Thoracic, Blood Glucose, Disease Models, Animal, Insulin Resistance, Male, Mice, Inbred C57BL, Obesity, Oleanolic Acid, Triterpenes, Vasoconstriction, Vasodilation, Biomarkers, Weight Gain, Disease Progression, Diet, Mediterranean, Adiposity, Diet, High-Fat
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