The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Veganism, vegetarianism, bone mineral density, and fracture risk: a systematic review and meta-analysis
Abstract
Context: The numbers of vegans and vegetarians have increased in the last decades. However, the impact of these diets on bone health is still under debate. Objective: This systematic review and meta-analysis sought to study the impact of vegetarian and vegan diets on bone mineral density (BMD) and fracture risk. Data Sources: A systematic search was conducted of PubMed, Scopus, and Science Direct, covering the period from the respective start date of each database to November 2017. Data Extraction: Two investigators evaluated 275 studies against the inclusion criteria (original studies in humans, written in English or Spanish and including vegetarian or vegan diets and omnivorous diets as factors with BMD values for the whole body, lumbar spine, or femoral neck and/or the number of fractures as the outcome) and exclusion criteria (articles that did not include imaging or studies that included participants who had suffered a fracture before starting the vegetarian or vegan diet). The quality assessment tool for observational cohort and cross-sectional studies was used to assess the quality of the studies. Results: Twenty studies including 37 134 participants met the inclusion criteria. Compared with omnivores, vegetarians and vegans had lower BMD at the femoral neck and lumbar spine and vegans also had higher fracture rates. Conclusions: Vegetarian and vegan diets should be planned to avoid negative consequences on bone health. Systematic Review Registration: PROSPERO registration no. CRD42017055508.
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“In support, a recent systematic review and meta-analysis revealed that vegans had a lower bone mineral density than omnivores [271].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [271]
Citations
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UK clinical guideline for the prevention and treatment of osteoporosis
Gregson, C. L., Armstrong, D. J., Bowden, J., Cooper, C., Edwards, J., Gittoes, N. J. L., Harvey, N., Kanis, J., Leyland, S., Low, R., et al. (2022) · Archives of Osteoporosis · doi:10.1007/s11657-022-01061-5 · Cited by 593
“Whilst there are inconsistencies in the evidence base for the associations between vegetarian and vegan diets and musculoskeletal health, consumption of a vegetarian or vegan diet has been associated with lower BMD at the lumbar spine and hip than an omnivore diet, and a vegan diet has been associated with higher frac…”
BackgroundNeufingerl, N., & Eilander, A. (2021) · Nutrients · doi:10.3390/nu14010029 · Cited by 484
“Our findings are in line with two recent systematic reviews and meta-analysis, which found that vegetarians and vegans had lower lumbar spine, femoral neck, and whole-body BMDs than omnivores [74,75].”
ResultThe Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals
Craig, W. J., Mangels, A. R., Fresán, U., Marsh, K. A., Miles, F. L., Saunders, A. V., Haddad, E. H., Heskey, C. E., JOHNSTON, P. K., Larson‐Meyer, E., et al. (2021) · Nutrients · doi:10.3390/nu13114144 · Cited by 379
Nutritional intake and bone health
Rizzoli, R., Biver, E., & Brennan‐Speranza, T. C. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00119-4 · Cited by 318
Thompson, A. S., Tresserra-Rimbau, A., Karavasiloglou, N., Jennings, A., Cantwell, M., Hill, C., Perez-Cornago, A., Bondonno, N. P., Murphy, N., Rohrmann, S., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.4714 · Cited by 203
Metadata
- Authors
- Iguacel, I., Miguel-Berges, M. L., Gómez-Bruton, A., Moreno, L. A., & Julián, C.
- Affiliations
- Universidad de Zaragoza (ES)
- University of Zaragoza, Zaragoza, Spain
- Corresponding author
- Iguacel, Isabel
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-10-29
- Volume
- 77
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2905381903
- Cited by
- 222
- References
- 90
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 35 · 2023: 35 · 2022: 30 · 2021: 32 · 2020: 27 · 2019: 10
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Zaguan (University of Zaragoza Repository) (submittedVersion)
- Funders
- FPU Predoctoral Programs (FPU014/00922)
- Spanish Ministry of Education and Science
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Keywords
- vegan diet, vegetarian diet, bone mineral density, fracture risk, bone health, femoral neck, lumbar spine, omnivorous diet, calcium intake
- MeSH terms
- Humans, Risk Factors, Diet, Vegetarian, Bone Density, Fractures, Bone
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