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Adherence to the Mediterranean diet and risk of depression: a systematic review and updated meta-analysis of observational studies
Abstract
CONTEXT: More than 300 million people worldwide have been diagnosed with depression, which is a leading cause of disability and disease burden. Elucidating dietary patterns that may reduce the risk of depression could help reduce the incidence of other diseases. DATA SOURCES: PubMed/MEDLINE, ISI Web of Science, Scopus, Embase, and Google Scholar databases were searched to identify relevant publications up to May 2018. STUDY SELECTION: All observational studies that considered the Mediterranean diet as the exposure variable and depression as the main outcome or as one of the outcome variables were included in this systematic review and meta-analysis. Two authors independently screened 3229 publications. A total of 14 observational studies were included in the meta-analysis. DATA EXTRACTION: Two authors independently extracted the data and assessed the risk of bias. RESULTS: The studies in the meta-analysis included a total of 56 043 participants. When 5 effect sizes from 4 cohort studies were combined, no significant association was observed between adherence to the Mediterranean diet and risk of depression (overall hazard ratio = 0.95; 95%CI, 0.79-1.16). When 3 effect sizes from 3 cohort studies that reported β coefficients were combined, again no significant association was found (β = -0.00; 95%CI, -0.12, 0.12). However, when 9 effect sizes from 9 cross-sectional studies were combined, an inverse significant association was found between adherence to the Mediterranean diet and risk of depression (overall odds ratio = 0.72; 95%CI, 0.60-0.87). CONCLUSIONS: The analysis of cohort studies revealed no significant association was found between adherence to the Mediterranean diet and risk of depression. However, an inverse significant association between adherence to the Mediterranean diet and odds of depression in cross-sectional studies.
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“Of note, one seemingly eligible study 28 was excluded for invalid findings due to inconsistent coding of effect directionality.”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [28]
Citations
Cites
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423
Mediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N., Kosti, R., & Scarmeas, N. (2013) · Annals of Neurology · doi:10.1002/ana.23944 · Cited by 793
Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia
Féart, C. (2009) · JAMA · doi:10.1001/jama.2009.1146 · Cited by 757
Association of the Mediterranean Dietary Pattern With the Incidence of Depression
Sánchez‐Villegas, A., Delgado‐Rodríguez, M., Alonso, Á., Schlatter, J., Lahortiga‐Ramos, F., Serra‐Majem, L., & Martínez‐González, M. Á. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.129 · Cited by 604
Dietary pattern and depressive symptoms in middle age
Akbaraly, T. N., Brunner, E. J., Ferrie, J. E., Marmot, M. G., Kivimaki, M., & Singh-Manoux, A. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.058925 · Cited by 602
Dietary patterns and depression risk: a meta-analysis
Li, Y., Lv, M.-R., Wei, Y.-J., Sun, L., Zhang, J.-X., Zhang, H.-G., & Li, B. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.04.020 · Cited by 599
Molendijk, M., Molero, P., Ortuño Sánchez-Pedreño, F., Van der Does, W., & Angel Martínez-González, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.022 · Cited by 550
Mental health survey of the adult population in Iran
Noorbala, A. A., Yazdi, S. A. B., Yasamy, M. T., & Mohammad, K. (2003) · The British Journal of Psychiatry · doi:10.1192/bjp.184.1.70 · Cited by 430
The association between diet quality, dietary patterns and depression in adults: a systematic review
Quirk, S. E., Williams, L. J., O'Neil, A. E., Pasco, J. A., Jacka, F. N., Housden, S., Berk, M., & Brennan-Olsen, S. L. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-175 · Cited by 419
Mediterranean dietary pattern and depression: the PREDIMED randomized trial
Sánchez-Villegas, A., Martínez-González, M. A., Estruch, R., Salas-Salvadó, J., Corella, D., Covas, M. I., Arós, F., Romaguera, D., Gómez-Gracia, E., Lapetra, J., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-208 · Cited by 403
Fruit and vegetable consumption and the risk of depression: A meta-analysis
Liu, X., Yan, Y., Li, F., & Zhang, D. (2015) · Nutrition · doi:10.1016/j.nut.2015.09.009 · Cited by 287
Rienks, J., Dobson, A. J., & Mishra, G. D. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.193 · Cited by 235
Effect of fruit and vegetable antioxidants on total antioxidant capacity of blood plasma
Harasym, J., & Olędzki, R. (2014) · Nutrition · doi:10.1016/j.nut.2013.08.019 · Cited by 208
Omega-3 fatty acids for depression in adults
Appleton, K. M., Sallis, H., Perry, R. E., Ness, A., & Churchill, R. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004692.pub4 · Cited by 187
Ψαλτοπούλου, Θ., Kyrozis, A., Stathopoulos, P., Trichopoulos, D., Vassilopoulos, D., & Trichopoulou, A. (2008) · Public Health Nutrition · doi:10.1017/s1368980007001607 · Cited by 184
Mediterranean diet and depressive symptoms among older adults over time
Skarupski, K. A., Tangney, C., Li, H., Evans, D. A., & Morris, M. C. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0437-x · Cited by 181
Sánchez‐Villegas, A., Henríquez-Sánchez, P., Ruiz‐Canela, M., Lahortiga‐Ramos, F., Molero, P., Toledo, E., & Martínez‐González, M. Á. (2015) · BMC Medicine · doi:10.1186/s12916-015-0428-y · Cited by 174
Diet and the risk of unipolar depression in adults: systematic review of cohort studies
Sanhueza, C., Ryan, L., & Foxcroft, D. (2012) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2012.01283.x · Cited by 172
Does the MIND diet decrease depression risk? A comparison with Mediterranean diet in the SUN cohort
Fresán, U., Bes‐Rastrollo, M., Segovia‐Siapco, G., Sánchez‐Villegas, A., Lahortiga‐Ramos, F., de la Rosa, P.-A., & Martínez‐González, M. Á. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1653-x · Cited by 172
Mediterranean diet and depression
Sánchez‐Villegas, A., Henríquez, P., Bes‐Rastrollo, M., & Doreste‐Alonso, J. (2006) · Public Health Nutrition · doi:10.1017/s1368980007668578 · Cited by 163
Veronese, N., Stubbs, B., Noale, M., Solmi, M., Luchini, C., & Maggi, S. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136390 · Cited by 163
Alisson-Silva, F., Kawanishi, K., & Varki, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.07.002 · Cited by 156
Hodge, A. M., Almeida, O. P., English, D. R., Giles, G. G., & Flicker, L. A. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212001986 · Cited by 112
Mediterranean diet adherence and self-reported psychological functioning in an Australian sample
Crichton, G. E., Bryan, J., Hodgson, J. M., & Murphy, K. J. (2013) · Appetite · doi:10.1016/j.appet.2013.06.088 · Cited by 109
Mamplekou, E., Bountziouka, V. P., Ψαλτοπούλου, Θ., Zeimbekis, A., Tsakoundakis, N., Papaerakleous, N., Gotsis, E., Metallinos, G., Pounis, G., Polychronopoulos, E., et al. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0091-0 · Cited by 108
Mediterranean Diet and Cognitive Decline in Women with Cardiovascular Disease or Risk Factors
Vercambre, M., Grodstein, F., Berr, C., & Kang, J. H. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.02.023 · Cited by 106
Malmir, H., Saneei, P., Larijani, B. A., & Esmaillzadeh, A. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1490-3 · Cited by 105
Self-citationLong-Term Fish Intake Is Associated With Less Severe Depressive Symptoms Among Elderly Men and Women
Bountziouka, V., Polychronopoulos, E., Zeimbekis, A., Papavenetiou, E., Ladoukaki, E., Papairakleous, N., Gotsis, E., Metallinos, G., Lionis, C. D., & Panagiotakos, D. B. (2009) · Journal of Aging and Health · doi:10.1177/0898264309340693 · Cited by 83
Mediterranean diet and depression among older individuals: The multinational MEDIS study
Masana, M. F., Haro, J. M., Mariolis, A. D., Piscopo, S., Valacchi, G., Bountziouka, V., Anastasiou, F., Zeimbekis, A., Tyrovola, D., Gotsis, E., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.05.012 · Cited by 68
Adjibade, M., Assmann, K. E., Andreeva, V. A., Lemogne, C., Herçberg, S., Galan, P., & Kesse‐Guyot, E. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1405-3 · Cited by 67
Mediterranean Diet, Food Consumption and Risk of Late-Life Depression: The Mugello Study
Pagliai, G., Sofi, F., Vannetti, F., Caiani, S., Pasquini, G., Lova, R. M., Cecchi, F., Sorbi, S., & Macchi, C. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1019-3 · Cited by 66
Kastorini, C.-M., Milionis, H. J., Ioannidi, A., Kalantzi, K. J., Nikolaou, V., Vemmos, K. N., Goudevenos, J. A., & Panagiotakos, D. B. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.07.012 · Cited by 65
The Association Between the Mediterranean Lifestyle and Depression
Sánchez‐Villegas, A., Ruiz‐Canela, M., Gea, A., Lahortiga‐Ramos, F., & Martínez‐González, M. Á. (2016) · Clinical Psychological Science · doi:10.1177/2167702616638651 · Cited by 60
Obesity, metabolic syndrome and Mediterranean diet: Impact on depression outcome
Garcı́a-Toro, M., Vicens-Pons, E., Gili, M., Roca, M., Serrano-Ripoll, M. J., Vives, M., Leiva, A., Yáñez, A. M., Bennasar‐Veny, M., & Oliván‐Blázquez, B. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.064 · Cited by 55
Saneei, P., Hajishafiee, M., Keshteli, A. H., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001926 · Cited by 55
Self-citationDepressive symptoms and diet: Their effects on prospective inflammation levels in the elderly
Luciano, M., Mõttus, R., Starr, J. M., McNeill, G., Jia, X., Craig, L. C. A., & Deary, I. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.007 · Cited by 53
Empirically Derived Dietary Patterns and Health-Related Quality of Life in the SUN Project
Ruano, C., Henríquez, P., Martínez‐González, M. Á., Bes‐Rastrollo, M., Ruiz‐Canela, M., & Sánchez‐Villegas, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061490 · Cited by 52
Milaneschi, Y., Bandinelli, S., Penninx, B. W. J. H., Vogelzangs, N., Corsi, A. M., Lauretani, F., Kisialiou, A., Vazzana, R., Terracciano, A., Guralnik, J. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.113 · Cited by 51
Αntonogeorgos, G., Panagiotakos, D. B., Pitsavos, C., Papageorgiou, C., Chrysohoou, C. A., Papadimitriou, G. N., & Stefanadis, C. (2012) · Annals of Epidemiology · doi:10.1016/j.annepidem.2012.06.103 · Cited by 51
Hernández-Galiot, A., & Goñi, I. (2017) · Nutrición Hospitalaria · doi:10.20960/nh.360 · Cited by 48
Lai, J. S., Oldmeadow, C., Hure, A. J., McEvoy, M., Byles, J., & Attia, J. (2016) · British Journal of Nutrition · doi:10.1017/s000711451500519x · Cited by 45
Adherence to a Dash-style diet in relation to depression and aggression in adolescent girls
Khayyatzadeh, S. S., Mehramiz, M., Mirmoosavi, S. J., Mazidi, M., Ziaee, A., Kazemi‐Bajestani, S. M. R., Ferns, G. A., Moharreri, F., & Ghayour‐Mobarhan, M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.075 · Cited by 43
Fish Consumption Moderates Depressive Symptomatology in Elderly Men and Women from the IKARIA Study
Chrysohoou, C. A., Tsitsinakis, G., Siassos, G., Ψαλτοπούλου, Θ., Galiatsatos, N., Metaxa, V., Lazaros, G. A., Miliou, A., Giakoumi, E., Mylonakis, C., et al. (2010) · Cardiology Research and Practice · doi:10.4061/2011/219578 · Cited by 42
Olveira, C., Olveira, G., Espíldora, F., Girón, R. M., Vendrell, M., Dorado, A., & Martínez‐García, M. Á. (2014) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2014.01.010 · Cited by 37
Nutrition status of primary care patients with depression and anxiety
Forsyth, A. K., Williams, P., & Deane, F. P. (2011) · Australian Journal of Primary Health · doi:10.1071/py11023 · Cited by 34
Denoth, F., Scalese, M., Siciliano, V., Renzo, L. D., LORENZO, A. D., & Molinaro, S. (2015) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-015-0225-9 · Cited by 30
Fish consumption and resilience to depression in Japanese company workers: a cross-sectional study
Yoshikawa, E., Nishi, D., & Matsuoka, Y. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0048-8 · Cited by 27
Ageing and the Mediterranean diet: a review of the role of dietary fats
Battino, M. A., & Ferreiro, M. S. (2004) · Public Health Nutrition · doi:10.1079/phn2004560 · Cited by 24
Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder.
Dana-Alamdari, L., Kheirouri, S., & Noorazar, S. G. (2015) · Europe PMC (PubMed Central) · Cited by 22
Poudel‐Tandukar, K., & Chandyo, R. K. (2016) · Food and Nutrition Bulletin · doi:10.1177/0379572116657268 · Cited by 17
[Vitamin B12, folic acid and mental function in the elderly].
Meertens, L., & Solano, L. (2005) · PubMed · Cited by 9
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Metadata
- Authors
- Shafiei, F., Salari-Moghaddam, A., Larijani, B., & Esmaillzadeh, A.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Endocrinology and Metabolism Clinical Sciences Institute (IR)
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Esmaillzadeh, Ahmad
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02-06
- Volume
- 77
- Issue
- 4
- Pages
- 230-239
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2911660708
- Cited by
- 147
- References
- 54
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 24 · 2023: 30 · 2022: 23 · 2021: 14 · 2020: 14 · 2019: 7
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tehran University of Medical Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- Mediterranean diet, dietary adherence, depression, depression risk, dietary habits, cross-sectional study, cohort studies, risk of bias
- MeSH terms
- Depressive Disorder, Humans, Diet, Mediterranean, Observational Studies as Topic
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