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Cited by 100Fungal Infections and StudiesAntifungal resistance and susceptibilityActinomycetales infections and treatment

The epidemiology of blastomycosis in Illinois and factors associated with death

Dworkin, Mark S., Duckro, Amy N., Proia, Laurie, Semel, Jeffery D., Huhn, Greg·2005·Clinical Infectious Diseases
DOI 10.1086/498152
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Abstract

BACKGROUND: Blastomycosis is a systemic fungal disease that may be asymptomatic or progressive and may lead to death. METHODS: In response to a reported increase in the number of cases of blastomycosis in Illinois, surveillance data reported to the Illinois Department of Public Health from January 1993 to August 2003 were analyzed and the medical records of 4 patients who died were reviewed. RESULTS: Among the 500 cases reported, the median age of the patients was 43 years (range, 4-87 years), and 34 patients (7%) died. Higher rates of mortality were observed among persons who were black, who were > or =65 years of age, and who were male. The median time from onset of illness to diagnosis was 128 days (range, 12-489 days). Death was associated with a time from onset of illness to diagnosis of > or =128 days (OR, 2.1; 95% CI, 1.0-4.8). During the period from 1993 through 2002, the number of cases reported per year increased from 24 to 87 (P<.05). CONCLUSIONS: The incidence of blastomycosis has been increasing in Illinois. To reduce mortality related to delay in diagnosis and treatment, medical providers need to be educated about blastomycosis, with an emphasis on symptom recognition, methods of diagnosis, and appropriate antifungal treatment.

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  • The increased risk for hospitalization among racial and ethnic minorities may signify blastomycosis-related health disparities.

    “The increased risk for hospitalization among racial and ethnic minorities may signify blastomycosis-related health disparities [178–180].”

    From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [180]

  • The increased risk for hospitalization among persons of nonwhite races lends further evidence to the existence of blastomycosis-related health disparities.

    “The increased risk for hospitalization among persons of nonwhite races lends further evidence to the existence of blastomycosis-related health disparities, as previously suspected (15–17).”

    From Blastomycosis Surveillance in 5 States, United States, 1987–2018 (2021) · cites this paper as [17]

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Authors
Dworkin, M. S., Duckro, A. N., Proia, L., Semel, J. D., & Huhn, G.
Affiliations
  • Illinois Department of Public Health (US)
  • Rush University Medical Center (US)
ORCID
Dworkin, Mark S.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2005-12
Volume
41
Issue
12
Pages
e107-e111
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/498152
OpenAlex
W2063747218
Cited by
100
References
22
Citations by year
2025: 2 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 6
FWCI
3.12
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Illinois Department of Public Health
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
Keywords
blastomycosis, mortality risk factors, delayed diagnosis, incidence trends, racial disparities, age and sex differences, systemic fungal infection, Illinois, antifungal therapy, symptom recognition
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Blastomycosis, Child, Child, Preschool, Female, Humans, Illinois, Male, Middle Aged

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