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Cited by 133

Head Injury and Risk of Alzheimer's Disease by Apolipoprotein E Genotype

O'Meara, E. S., Kukull, W. A., Sheppard, L., Bowen, J. D., McCormick, W. C., Teri, L., Pfanschmidt, M., Thompson, J. D. +2 more·1997·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a009290
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Abstract

Head injury and apolipoprotein E (APOE)-epsilon 4 (e4) genotype have each been associated with increased risk of Alzheimer's disease. If APOE-e4 affects neuronal viability and branching, and if response to head injury differs in e4 patients, then the association between head injury and Alzheimer's disease may vary with the presence of the e4 allele. The authors examined this association in a case-control study conducted between 1987 and 1995 among enrollees of the Group Health Cooperative of Puget Sound, a health maintenance organization in Seattle, Washington. Proxy informants reported prior head injury with loss of consciousness for 32 of 349 patients with probable Alzheimer's disease and for 16 of 342 control subjects of similar age and sex who had been randomly selected from the same population (odds ratio (OR) = 2.1, 95% confidence interval (CI) 1.1-3.8). Elevated risk was observed among men (OR = 4.2, 95% CI 1.5-11.5) but not among women (OR = 1.1, 95% CI 0.5-2.6). No significant variation in the head injury-Alzheimer's disease risk relation by APOE-e4 genotype was found among 230 cases and 309 controls (OR = 3.1 (95% CI 0.7-14.6) for persons with at least one e4 allele and OR = 2.0 (95% CI 0.8-5.2) for those without e4). Neither age, education, race, type of proxy informant, nor duration of relationship with the proxy confounded the association. Head injury with loss of consciousness, although uncommon in this sample, was associated with increased risk of Alzheimer's d…

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Crossref · 10.1093/oxfordjournals.aje.a009290

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  • Synergistic effects of head injury and APOE genotypes in AD were reported by some studies but not all.

    “Synergistic effects of head injury and APOE genotypes in AD were reported by some (30–32), but not all studies (53;54).”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [53]

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Authors
O'Meara, E. S., Kukull, W. A., Sheppard, L., Bowen, J. D., McCormick, W. C., Teri, L., Pfanschmidt, M., Thompson, J. D., Schellenberg, G. D., & Larson, E. B.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
1997-09-01
Volume
146
Issue
5
Pages
373-384
ISSN
  • 0002-9262
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a009290
Cited by
133
References
1
Language
en

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