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Cited by 107Trace Elements in HealthFolate and B Vitamins ResearchSpinal Dysraphism and Malformations

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Maternal Supplemental and Dietary Zinc Intake and the Occurrence of Neural Tube Defects in California

Velie, E. M., Block, G., Shaw, G. M., Samuels, S. J., Schaffer, D. M, Kulldorff, M.·1999·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a010059
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Abstract

The authors investigated the association between maternal preconceptional supplemental and dietary zinc intake and risk of neural tube defects (NTDs) in a population-based case-control study conducted between 1989 and 1991 in California. Cases were 430 NTD-affected fetuses/infants, and controls were 429 randomly selected non-malformed infants. Mothers reported their preconceptional use of vitamin, mineral, and food supplements, and completed a 98-item food frequency questionnaire. Increased total preconceptional zinc intake was associated with a reduced risk for NTDs (quintile 5 vs. quintile 1, odds ratio (OR) = 0.65, 95% confidence interval (CI) 0.43, 0.99). Phytate intake, a constituent of the diet known to impede zinc absorption, appeared to modify the zinc - NTD association. In addition, increased servings of animal products, the most bioavailable food source of zinc, was associated with a reduced risk for NTDs (quintile 5 vs. quintile 1, OR = 0.49, 95% CI 0.32, 0.76). Risk estimates for zinc intake were changed little after controlling for multiple sociodemographic factors and total folate intake, but were attenuated after controlling for nutrients highly correlated with dietary sources of zinc, such as protein. In sum, the analyses indicate that risk of NTDs in infants and fetuses decreased with increasing maternal preconceptional zinc intake. However, it remains unclear whether increased zinc intake, or another nutrient or combination of nutrients highly correlated with zinc intake in the diet, is causally associated with reduced NTD risk.

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Crossref · 10.1093/oxfordjournals.aje.a010059

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Metadata

Authors
Velie, E. M., Block, G., Shaw, G. M., Samuels, S. J., Schaffer, D. M., & Kulldorff, M.
Affiliations
  • University of California, Berkeley (US)
  • University of California, Davis (US)
  • Kaiser Permanente (US)
  • National Institutes of Health (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
1999-09-15
Volume
150
Issue
6
Pages
605-616
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a010059
OpenAlex
W2122678034
Cited by
107
References
35
Citations by year
2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
3.16
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
  • Health Sciences › Medicine › Clinical Neurology › Spinal Dysraphism and Malformations
Keywords
neural tube defects, dietary zinc, phytic acid, zinc absorption, animal products, folic acid, prenatal nutrition, birth defects risk
MeSH terms
California, Diet, Ethnicity, Feeding Behavior, Female, Humans, Infant, Newborn, Neural Tube Defects, Pregnancy, Vitamins, Zinc, Effect Modifier, Epidemiologic, Body Mass Index, Chi-Square Distribution, Likelihood Functions, Case-Control Studies, Preconception Care, Dietary Supplements

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